{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:56:43Z","timestamp":1790557003614,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T00:00:00Z","timestamp":1790467200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T00:00:00Z","timestamp":1790467200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Peripheral Nervous Sys"],"published-print":{"date-parts":[[2026,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Data on cardiovascular autonomic neuropathy (CAN) are sparse in Charcot\u2013Marie\u2013Tooth disease. We aimed to determine the prevalence of CAN in CMT1A and CMTX1 and its associations with neuropathy severity and heart rate variability (HRV), compared with age\u2010 and sex\u2010matched controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Thirty\u2010six CMT1A, 24 CMTX1 patients, and 62 controls underwent cardiovascular autonomic testing including the modified Ewing battery (Expiration: Inspiration ratio, 30:15 ratio, Valsalva ratio; complete in 41\/62 controls), orthostatic blood pressure measurement, and HRV analysis from 10\u2010min supine\u2013standing recordings. Abnormality was defined using age\u2010stratified 2.3rd\u2010percentile cutoffs. CMT Neuropathy Score version 2 (CMTNSv2) and Survey of Autonomic Symptoms were recorded. Comparisons used Fisher's exact test and the Kruskal\u2013Wallis test with Holm correction; HRV was age\u2010 and sex\u2010adjusted.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      CAN was present in 30.6% of CMT1A and 33.3% of CMTX1, versus 10.0% of controls (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.011). Definite CAN occurred only in CMT1A (11.1%), although the CMT1A\u2013CMTX1 contrast was not significant (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.14). The Valsalva ratio was lower in CMT1A than in CMTX1 (median 1.54 vs. 1.89,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001), with abnormal values confined to CMT1A (14.7%). After age and sex adjustment, vagal HRV was reduced in CMT1A but not CMTX1.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interpretation<\/jats:title>\n                    <jats:p>CAN affects approximately one\u2010third of patients with CMT1A and CMTX1, roughly three times the control prevalence. Overall prevalence was similar in the two genotypes, but Valsalva impairment was confined to CMT1A, indicating that similar prevalence does not imply an identical pattern of involvement. Cardiovascular autonomic assessment warrants consideration in these patients, particularly perioperatively.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jns.70173","type":"journal-article","created":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:49:40Z","timestamp":1790556580000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cardiovascular Autonomic Neuropathy in Charcot\u2013Marie\u2013Tooth Disease: A Genotype\u2010Stratified Study of\n                    <scp>PMP22<\/scp>\n                    Duplication and\n                    <scp>GJB1<\/scp>\n                    Mutation Carriers"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-3307-7092","authenticated-orcid":false,"given":"Kry\u0161tof","family":"Pr\u00e1\u0161il","sequence":"first","affiliation":[{"name":"Department of Neurology, Second Faculty of Medicine Charles University, Motol and Homolka University Hospital  Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2406-8670","authenticated-orcid":false,"given":"Veronika","family":"Poto\u010dkov\u00e1","sequence":"additional","affiliation":[{"name":"Department of Neurology, Second Faculty of Medicine Charles University, Motol and Homolka University Hospital  Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7751-2587","authenticated-orcid":false,"given":"Tom\u00e1\u0161","family":"Ned\u011blka","sequence":"additional","affiliation":[{"name":"Department of Neurology, Second Faculty of Medicine Charles University, Motol and Homolka University Hospital  Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-0157-2064","authenticated-orcid":false,"given":"Al\u017eb\u011bta","family":"Pr\u00e1\u0161ilov\u00e1","sequence":"additional","affiliation":[{"name":"Institute of Experimental Medicine Academy of Sciences of the Czech Republic  Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-2206-8025","authenticated-orcid":false,"given":"Radim","family":"Mazanec","sequence":"additional","affiliation":[{"name":"Department of Neurology, Second Faculty of Medicine Charles University, Motol and Homolka University Hospital  Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,27]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572\u2010025\u201000679\u20102"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415\u2010023\u201011559\u20108"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp\u20102014\u2010308826"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awad187"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.4239\/wjd.v5.i1.17"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.14797\/mdcj\u201014\u20104\u2010251"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1042\/cs0550321"},{"issue":"3","key":"e_1_2_8_9_1","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1093\/oxfordjournals.eurheartj.a014868","article-title":"Heart Rate Variability. 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