{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T12:59:28Z","timestamp":1790773168315,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Peripheral Nervous Sys"],"published-print":{"date-parts":[[2026,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>In anti\u2010myelin\u2010associated glycoprotein (MAG) neuropathy, the efficacy of rituximab (RTX) is not demonstrated in randomized controlled trials. Combinations of RTX with conventional chemotherapy (immunochemotherapy, ICT) may provide potential benefit, but systematic evaluations are lacking. We aimed to compare the efficacy and safety of RTX and ICT in a multicenter retrospective real\u2010world cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients with anti\u2010MAG antibody titers &gt;\u200910\u2009000 Buhlmann titer units (BTUs) were included. Treatment response was defined as an improvement of \u2265\u20091 point in the Overall Neuropathy Limitation Scale (ONLS) compared to baseline. Propensity score matching was used to account for differences in baseline characteristics between treatment groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 230 patients were included: 150 received RTX and 80 received ICT. Mean follow\u2010up was 4\u2009years (range, 1\u201320\u2009years). One year after treatment, clinical improvement occurred in 61\/147 (41%) patients treated with RTX and 39\/78 (50%) treated with ICT (OR\u2009=\u20091.4 [0.8\u20132.5]\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.3). At last follow\u2010up, clinical improvement occurred in 55\/150 (37%) patients treated with RTX and 31\/80 (39%) treated with ICT (OR\u2009=\u20091.1 [0.6\u20131.9]\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.8). Propensity score matching yielded similar results. Among ICT regimens, dexamethasone\u2013RTX\u2013cyclophosphamide was associated with the highest response rate. RTX induction, 1\u2009g\u2009days 1 and 15, seemed superior to four\u2010weekly infusions. Adverse events were more frequent with ICT than with RTX (28% vs. 15%; OR\u2009=\u20092.20 [1.07\u20134.54],\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.02).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interpretation<\/jats:title>\n                    <jats:p>In this cohort, adding chemotherapy to RTX was not associated with greater long\u2010term improvement, despite a higher rate of adverse events. Prospective controlled studies are needed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jns.70175","type":"journal-article","created":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T12:17:29Z","timestamp":1790770649000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Rituximab With or Without Chemotherapy for Anti\u2010\n                    <scp>MAG<\/scp>\n                    Neuropathy: A Retrospective Multicenter Real\u2010World Study"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5591-2774","authenticated-orcid":false,"given":"Delmont","family":"Emilien","sequence":"first","affiliation":[{"name":"Referral Center for Neuromuscular Diseases and ALS, La Timone Hospital Aix\u2010Marseille University  Marseille 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Peripheral Neuropathies UR 20218, University Hospital of Limoges  Limoges France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4685-0786","authenticated-orcid":false,"given":"Frachet","family":"Simon","sequence":"additional","affiliation":[{"name":"Reference Center for Rare Peripheral Neuropathies UR 20218, University Hospital of Limoges  Limoges France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9765-709X","authenticated-orcid":false,"given":"Labeyrie","family":"C\u00e9line","sequence":"additional","affiliation":[{"name":"Referral Centre for Rare Neuropathies (CERAMIC)  Le Kremlin\u2010Bic\u00eatre France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1012-9783","authenticated-orcid":false,"given":"Echaniz\u2010Laguna","family":"Andoni","sequence":"additional","affiliation":[{"name":"Referral Centre for Rare Neuropathies (CERAMIC)  Le Kremlin\u2010Bic\u00eatre France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4055-617X","authenticated-orcid":false,"given":"Noel","family":"Nicolas","sequence":"additional","affiliation":[{"name":"Service de M\u00e9decine Interne et Immunologie Clinique CEA, INSERM UMR 1184  Le Kremlin Bic\u00eatre France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2850-2374","authenticated-orcid":false,"given":"Svahn","family":"Juliette","sequence":"additional","affiliation":[{"name":"ENMG Department, Referral Center for Neuromuscular Diseases H\u00f4pital Neurologique P Wertheimer, Hospices Civils de Lyon  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1563-9432","authenticated-orcid":false,"given":"Pegat","family":"Antoine","sequence":"additional","affiliation":[{"name":"ENMG Department, Referral Center for Neuromuscular Diseases H\u00f4pital Neurologique P Wertheimer, Hospices Civils de Lyon  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bouhour","family":"Fran\u00e7oise","sequence":"additional","affiliation":[{"name":"ENMG Department, Referral Center for Neuromuscular Diseases H\u00f4pital Neurologique P Wertheimer, Hospices Civils de Lyon  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6781-7395","authenticated-orcid":false,"given":"Cluse","family":"Florent","sequence":"additional","affiliation":[{"name":"ENMG Department, Referral Center for Neuromuscular Diseases H\u00f4pital Neurologique P Wertheimer, Hospices Civils de Lyon  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4218-6128","authenticated-orcid":false,"given":"Puma","family":"Angela","sequence":"additional","affiliation":[{"name":"Referral Center for Neuromuscular Disease, Pasteur 2 Hospital 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