{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:26:03Z","timestamp":1740126363074,"version":"3.37.3"},"reference-count":10,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,3,22]],"date-time":"2013-03-22T00:00:00Z","timestamp":1363910400000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"MRC"},{"DOI":"10.13039\/501100013372","name":"Wellcome Trust Centre for Mitochondrial Research","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100013372","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100012295","name":"NIHR Newcastle Biomedical Research Centre","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100012295","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000774","name":"Newcastle University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000774","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Peripheral Nervous Sys"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Symmetrical polyneuropathy is a common feature of mitochondrial disease. Both axonal and demyelinating types are described, with Schwann cell abnormalities demonstrated on nerve biopsy. Some authors have also suggested an increased incidence of entrapment neuropathy. We identified 738 adult patients with proven mitochondrial disease seen in our centre in the past 25\u2009years. One\u2010hundred sixty seven of these patients had undergone nerve conduction studies as part of their routine clinical care, and the results of these studies were reviewed. We found an incidence rate of carpal tunnel syndrome (<jats:styled-content style=\"fixed-case\">CTS<\/jats:styled-content>) of 50.7 per 100,000 person\u2010years; 32.5 per 100,000 person\u2010years for men and 65.3 per 100,000 person\u2010years for women. One other patient had evidence of ulnar neuropathy at the elbow. The incidence of <jats:styled-content style=\"fixed-case\">CTS<\/jats:styled-content> in mitochondrial disease is similar to published rates for the <jats:styled-content style=\"fixed-case\">UK<\/jats:styled-content> general population. We found no evidence that mitochondrial disease <jats:italic>per se<\/jats:italic> increases the risk of entrapment neuropathy. We suggest that the pathophysiological mechanisms for the development of polyneuropathy in mitochondrial disease are quite distinct from the pathophysiology of CTS. Furthermore, it is essential that patients with mitochondrial disease who present with upper limb paraesthesia be referred for neurophysiological testing, so that treatable\u00a0<jats:styled-content style=\"fixed-case\">CTS<\/jats:styled-content> is not missed.<\/jats:p>","DOI":"10.1111\/jns5.12009","type":"journal-article","created":{"date-parts":[[2013,3,23]],"date-time":"2013-03-23T06:30:10Z","timestamp":1364020210000},"page":"59-61","source":"Crossref","is-referenced-by-count":1,"title":["Incidence of carpal tunnel syndrome in adult patients with mitochondrial disease"],"prefix":"10.1111","volume":"18","author":[{"given":"Roger G.","family":"Whittaker","sequence":"first","affiliation":[{"name":"Department of Clinical Neurophysiology Royal Victoria Infirmary  Newcastle upon Tyne UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth","family":"Hall","sequence":"additional","affiliation":[{"name":"University of Toronto  Toronto ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad K.","family":"Mansoor","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurophysiology Royal Victoria Infirmary  Newcastle upon Tyne UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert W.","family":"Taylor","sequence":"additional","affiliation":[{"name":"Wellcome Trust Centre for Mitochondrial Research, Institute of Ageing and Health Newcastle University  Newcastle upon Tyne UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Douglass M.","family":"Turnbull","sequence":"additional","affiliation":[{"name":"Wellcome Trust Centre for Mitochondrial Research, Institute of Ageing and Health Newcastle University  Newcastle upon Tyne UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,3,22]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmd.2009.10.001"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-4598(200008)23:8<1280::AID-MUS20>3.0.CO;2-Y"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.74.12.1674"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1529-8027.2002.02027.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000117420"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clineuro.2004.07.001"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000338533.88960.b9"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.58.11.1589"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-003-0981-8"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.58.2.289"}],"container-title":["Journal of the Peripheral Nervous System"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjns5.12009","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjns5.12009","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jns5.12009","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T19:17:00Z","timestamp":1698693420000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jns5.12009"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,3]]},"references-count":10,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,3]]}},"alternative-id":["10.1111\/jns5.12009"],"URL":"https:\/\/doi.org\/10.1111\/jns5.12009","archive":["Portico"],"relation":{},"ISSN":["1085-9489","1529-8027"],"issn-type":[{"type":"print","value":"1085-9489"},{"type":"electronic","value":"1529-8027"}],"subject":[],"published":{"date-parts":[[2013,3]]}}}