{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:24:22Z","timestamp":1792787062483,"version":"4.5.0"},"reference-count":81,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,3,22]],"date-time":"2013-03-22T00:00:00Z","timestamp":1363910400000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Baxter\/PNS"},{"name":"Lord Kelvin Adam Smith postgraduate scholarship scheme"},{"DOI":"10.13039\/501100000268","name":"BBSRC","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000268","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Peripheral Nervous Sys"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Acute canine polyradiculoneuritis (\n                    <jats:styled-content style=\"fixed-case\">ACP<\/jats:styled-content>\n                    ) is considered to be the canine equivalent of the human peripheral nerve disorder Guillain\u2010Barr\u00e9 syndrome (\n                    <jats:styled-content style=\"fixed-case\">GBS<\/jats:styled-content>\n                    ); an aetiological relationship, however, remains to be demonstrated. In\n                    <jats:styled-content style=\"fixed-case\">GBS<\/jats:styled-content>\n                    , anti\u2010glycolipid antibodies (Abs) are considered as important disease mediators. To address the possibility of common Ab biomarkers, the sera of 25\n                    <jats:styled-content style=\"fixed-case\">ACP<\/jats:styled-content>\n                    dogs, 19 non\u2010neurological, and 15 epileptic control dogs were screened for\n                    <jats:styled-content style=\"fixed-case\">IgG<\/jats:styled-content>\n                    Abs to 10 glycolipids and their 1\u2009:\u20091 heteromeric complexes using combinatorial glycoarrays. Anti\u2010\n                    <jats:styled-content style=\"fixed-case\">GM2<\/jats:styled-content>\n                    ganglioside Abs were detected in 14\/25\n                    <jats:styled-content style=\"fixed-case\">ACP<\/jats:styled-content>\n                    dogs, and anti\u2010\n                    <jats:styled-content style=\"fixed-case\">GA1<\/jats:styled-content>\n                    Abs in one further dog. All controls except for one were negative for anti\u2010glycolipid Abs. In this cohort of cases and controls, the glycoarray screen reached a diagnostic sensitivity of 60% and a specificity of 97%; a lower sensitivity (32%) was reported using a conventional glycolipid\n                    <jats:styled-content style=\"fixed-case\">ELISA<\/jats:styled-content>\n                    . To address the possible pathogenic role for anti\u2010\n                    <jats:styled-content style=\"fixed-case\">GM2<\/jats:styled-content>\n                    Abs in\n                    <jats:styled-content style=\"fixed-case\">ACP<\/jats:styled-content>\n                    , we identified\n                    <jats:styled-content style=\"fixed-case\">GM2<\/jats:styled-content>\n                    in canine sciatic nerve by both mass spectrometry and thin layer chromatography overlay. In immunohistological studies,\n                    <jats:styled-content style=\"fixed-case\">GM2<\/jats:styled-content>\n                    was localized predominantly to the abaxonal Schwann cell membrane. The presence of anti\u2010\n                    <jats:styled-content style=\"fixed-case\">GM2<\/jats:styled-content>\n                    Abs in\n                    <jats:styled-content style=\"fixed-case\">ACP<\/jats:styled-content>\n                    suggests that it may share a similar pathophysiology with\n                    <jats:styled-content style=\"fixed-case\">GBS<\/jats:styled-content>\n                    , for which it could thus be considered a naturally occurring animal model.\n                  <\/jats:p>","DOI":"10.1111\/jns5.12011","type":"journal-article","created":{"date-parts":[[2013,3,23]],"date-time":"2013-03-23T02:30:10Z","timestamp":1364005810000},"page":"75-88","source":"Crossref","is-referenced-by-count":36,"title":["Anti\u2010\n                    <scp>GM2<\/scp>\n                    ganglioside antibodies are a biomarker for\u00a0acute canine polyradiculoneuritis"],"prefix":"10.1111","volume":"18","author":[{"given":"Angie","family":"Rupp","sequence":"first","affiliation":[{"name":"Neuroimmunology Group, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences University of Glasgow  Glasgow UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesc","family":"Galban\u2010Horcajo","sequence":"additional","affiliation":[{"name":"Neuroimmunology Group, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences University of Glasgow  Glasgow UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ezio","family":"Bianchi","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medical Sciences University of Bologna  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Dondi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques","family":"Penderis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna","family":"Cappell","sequence":"additional","affiliation":[{"name":"Neuroimmunology Group, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences University of Glasgow  Glasgow UK"},{"name":"Glasgow Polyomics, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences University of Glasgow  Glasgow UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl","family":"Burgess","sequence":"additional","affiliation":[{"name":"Glasgow Polyomics, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences University of 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