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Although Guillain, Barr\u00e9, and Strohl summarised the syndrome based on observations of two French infantrymen, 2012 saw the beginning of an ambitious collaborative study designed to collect detailed data from at least 1,000 patients worldwide (<jats:styled-content style=\"fixed-case\">IGOS<\/jats:styled-content>, <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.gbsstudies.org\/about-igos\">www.gbsstudies.org\/about\u2010igos<\/jats:ext-link>). Progress has been made in many areas even since <jats:styled-content style=\"fixed-case\">GBS<\/jats:styled-content> was last reviewed in this journal in 2009. <jats:styled-content style=\"fixed-case\">GBS<\/jats:styled-content> subsequently received prominent attention in light of concerns regarding <jats:styled-content style=\"fixed-case\">H1N1<\/jats:styled-content> influenza vaccinations, and several large\u2010scale surveillance studies resulted. Despite these developments, and promising pre\u2010clinical studies, disease\u2010modifying therapies for <jats:styled-content style=\"fixed-case\">GBS<\/jats:styled-content> have not substantially altered since intravenous immunoglobulin was introduced over 20\u2009years ago. In other areas, management has improved. Antibiotic prophylaxis in ventilated patients reduces respiratory tract infection, thromboprophylaxis has reduced the risk of venous thromboembolism, and there is increasing awareness of the benefit of high\u2010intensity rehabilitation. This article highlights some of the interesting and thought\u2010provoking developments of the last 3\u2009years, and is based on a plenary lecture given at the 2012 Peripheral Nerve Society (PNS) meeting.<\/jats:p>","DOI":"10.1111\/jns5.12020","type":"journal-article","created":{"date-parts":[[2013,5,15]],"date-time":"2013-05-15T17:23:15Z","timestamp":1368638595000},"page":"99-112","source":"Crossref","is-referenced-by-count":29,"title":["Update on Guillain\u2010Barr\u00e9 syndrome"],"prefix":"10.1111","volume":"18","author":[{"given":"Simon","family":"Rinaldi","sequence":"first","affiliation":[{"name":"Nuffield Department of Clinical Neurosciences University of Oxford Oxford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,6,19]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-5728(00)00369-6"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-010-8246-7"},{"key":"e_1_2_9_4_1","first-page":"565","article-title":"Criteria for diagnosis of Guillain\u2010Barre syndrome","volume":"3","author":"Asbury AK","year":"1978","journal-title":"Ann Neurol"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410270707"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid1802.111126"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2007.03.004"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00009-11"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12028-011-9536-5"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2007.07.008"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(12)70134-5"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2006.05.018"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2007.03.001"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI59110"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.305.6865.1330"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1191\/0269215502cr475oa"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2012.03767.x"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2004.01.003"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000148727.02732.01"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.177.6.4211"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2007.07.008"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cis454"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4279-04.2005"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI6837"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kws195"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI37338"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2012.04.077"},{"key":"e_1_2_9_28_1","first-page":"1462","article-title":"Sur un syndrome de radiculon\u00e9urite avec hyperalbuminose du liquide c\u00e9phalo\u2010rachidien sans reaction cellulaire. 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