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While in some countries of Western Europe, the United States and Japan the dominant form of <jats:styled-content style=\"fixed-case\">HMSN<\/jats:styled-content> is the most frequent, in other countries such as those of the Mediterranean Basin, the autosomal recessive form (<jats:styled-content style=\"fixed-case\">AR\u2010CMT<\/jats:styled-content>) is more common. Autosomal recessive <jats:styled-content style=\"fixed-case\">CMT<\/jats:styled-content> cases are generally characterized by earlier onset, usually before the age of 2 or 3\u2009\u2009years, and rapid clinical progression that results in severe polyneuropathy and more marked distal limb deformities such as pes equino\u2010varus, claw\u2010like hands, and often major spinal deformities. Recent clinical, morphological and molecular investigations of <jats:styled-content style=\"fixed-case\">CMT<\/jats:styled-content> families with autosomal recessive inheritance allowed the identification of many genes such as <jats:italic><jats:styled-content style=\"fixed-case\">GDAP1<\/jats:styled-content>, <jats:styled-content style=\"fixed-case\">MTMR2<\/jats:styled-content>, <jats:styled-content style=\"fixed-case\">SBF2<\/jats:styled-content>, <jats:styled-content style=\"fixed-case\">NDRG1<\/jats:styled-content>, <jats:styled-content style=\"fixed-case\">EGR2<\/jats:styled-content>, <jats:styled-content style=\"fixed-case\">SH3TC2<\/jats:styled-content>, <jats:styled-content style=\"fixed-case\">PRX<\/jats:styled-content>, <jats:styled-content style=\"fixed-case\">FGD4<\/jats:styled-content><\/jats:italic>, and <jats:italic><jats:styled-content style=\"fixed-case\">FIG4<\/jats:styled-content><\/jats:italic>, implicated in demyelinating forms (<jats:styled-content style=\"fixed-case\">ARCMT1<\/jats:styled-content> or <jats:styled-content style=\"fixed-case\">CMT4<\/jats:styled-content>), and <jats:italic><jats:styled-content style=\"fixed-case\">LMNA<\/jats:styled-content>, <jats:styled-content style=\"fixed-case\">MED25<\/jats:styled-content>, <jats:styled-content style=\"fixed-case\">HINT1<\/jats:styled-content>, <jats:styled-content style=\"fixed-case\">GDAP1<\/jats:styled-content>, <jats:styled-content style=\"fixed-case\">LRSAM1<\/jats:styled-content>, <jats:styled-content style=\"fixed-case\">NEFL<\/jats:styled-content>, <jats:styled-content style=\"fixed-case\">HSPB1<\/jats:styled-content><\/jats:italic> and <jats:italic><jats:styled-content style=\"fixed-case\">MFN2<\/jats:styled-content><\/jats:italic> in axonal forms (<jats:styled-content style=\"fixed-case\">ARCMT2<\/jats:styled-content>). However, many patients remain without genetic diagnosis to date, prompting investigations into <jats:styled-content style=\"fixed-case\">ARCMT<\/jats:styled-content> families in order to help discover new genes and common pathways. This review summarizes recent advances regarding the genotypes and corresponding phenotypes of <jats:styled-content style=\"fixed-case\">AR\u2010CMT<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/jns5.12026","type":"journal-article","created":{"date-parts":[[2013,5,24]],"date-time":"2013-05-24T17:48:45Z","timestamp":1369417725000},"page":"113-129","source":"Crossref","is-referenced-by-count":71,"title":["Autosomal recessive Charcot\u2010Marie\u2010Tooth disease: from genes to phenotypes"],"prefix":"10.1111","volume":"18","author":[{"given":"Meriem","family":"Tazir","sequence":"first","affiliation":[{"name":"Service de Neurologie University Hospital Mustapha Bacha Alger Algeria"},{"name":"Laboratoire de NeuroSciences Universit\u00e9 d'Alger 1 Alger Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mounia","family":"Bellatache","sequence":"additional","affiliation":[{"name":"Service de Neurologie University Hospital Mustapha Bacha Alger 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