{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T12:29:07Z","timestamp":1769171347999,"version":"3.49.0"},"reference-count":54,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,9,12]],"date-time":"2013-09-12T00:00:00Z","timestamp":1378944000000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institute of Health Research","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Canadian Foundation for Innovation"},{"DOI":"10.13039\/100005301","name":"American College of Surgeons","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100005301","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100002280","name":"Plastic Surgery Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100002280","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Peripheral Nervous Sys"],"published-print":{"date-parts":[[2013,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Transgenic mice have been previously used to assess nerve regeneration following peripheral nerve injury. However, mouse models are limited by their small caliber nerves, short nerve lengths, and their inability to fully participate during behavioral assessments. The transgenic <jats:italic>Thy1<\/jats:italic> <jats:styled-content style=\"fixed-case\">GFP<\/jats:styled-content> rat is a novel transgenic rat model designed to assess regeneration following peripheral nerve injury. However, return of functional and behavioral recovery following nerve injury has not yet been evaluated in these rats. In this study, we ask whether differences in anatomy, recovery of locomotion, myological, and histomorphological measures exist between transgenic <jats:italic>Thy1<\/jats:italic> <jats:styled-content style=\"fixed-case\">GFP<\/jats:styled-content> rats when compared to wild type (<jats:styled-content style=\"fixed-case\">WT<\/jats:styled-content>) Sprague Dawley rats following unilateral sciatic nerve injury. We found that both motor and sensory neuronal architecture, overground and skilled locomotion, muscle force, motor unit number estimation (<jats:styled-content style=\"fixed-case\">MUNE<\/jats:styled-content>) and wet muscle weights, and histomorphometric assessments are similar between both genetic phenotypes. Overall, these data support the use of the transgenic <jats:italic>Thy1<\/jats:italic>\u2010<jats:styled-content style=\"fixed-case\">GFP<\/jats:styled-content> rat in experiments assessing functional and behavioral recovery following nerve injury and repair.<\/jats:p>","DOI":"10.1111\/jns5.12035","type":"journal-article","created":{"date-parts":[[2013,7,29]],"date-time":"2013-07-29T19:51:45Z","timestamp":1375127505000},"page":"220-231","source":"Crossref","is-referenced-by-count":26,"title":["Functional recovery following peripheral nerve injury in the transgenic <i>Thy1<\/i>\u2010<scp>GFP<\/scp> rat"],"prefix":"10.1111","volume":"18","author":[{"given":"Stephen W. P.","family":"Kemp","sequence":"first","affiliation":[{"name":"Department of Surgery, Division of Plastic and Reconstructive Surgery The Hospital for Sick Children Toronto Ontario Canada"},{"name":"The Hospital for Sick Children Research Institute Program in Neuroscience and Mental Health Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter D.","family":"Phua","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Plastic and Reconstructive Surgery The Hospital for Sick Children Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krisanne N.","family":"Stanoulis","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Plastic and Reconstructive Surgery The Hospital for Sick Children Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew D.","family":"Wood","sequence":"additional","affiliation":[{"name":"The Hospital for Sick Children Research Institute Program in Neuroscience and Mental Health Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward H.","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Plastic and Reconstructive Surgery The Hospital for Sick Children Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tessa","family":"Gordon","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Plastic and Reconstructive Surgery The Hospital for Sick Children Toronto Ontario Canada"},{"name":"The Hospital for Sick Children Research Institute Program in Neuroscience and Mental Health Toronto Ontario Canada"},{"name":"Division of Plastic and Reconstructive Surgery University of Toronto Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregory H.","family":"Borschel","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Plastic and Reconstructive Surgery The Hospital for Sick Children Toronto Ontario Canada"},{"name":"The Hospital for Sick Children Research Institute Program in Neuroscience and Mental Health Toronto Ontario Canada"},{"name":"Division of Plastic and Reconstructive Surgery University of Toronto Toronto Ontario Canada"},{"name":"University of Toronto Institute of Biomaterials and Biomedical Engineering Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,9,12]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1090940210"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2011.1857"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1227\/01.NEU.0000345942.14391.1C"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-198901000-00024"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.21366"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.1994.1104"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/med\/9780195169904.001.0001"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2009.11.005"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01972876"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.284.5420.1670"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4886(82)90234-5"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/1753193410366191"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)00084-2"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2007.01.039"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1262\/jrd.49.523"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2007.06.004"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2007.07.003"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(85)90833-9"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-199612000-00023"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.tea.2008.0338"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2010.07130.x"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2011.03.017"},{"key":"e_1_2_6_24_1","volume-title":"Nerve Injuries: Operative Results for Major Nerve Injuries, Entrapments and Tumors","author":"Kline DG","year":"1995"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1227\/01.NEU.0000368545.83463.91"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1001\/archfacial.2010.71"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1088\/1741-2560\/2\/2\/003"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00904.2006"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0004-282X2006000500010"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.34.2.121"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2008.01.022"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2011.10.011"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4598(199808)21:8<1095::AID-MUS20>3.0.CO;2-S"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005373-199807000-00025"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1998.78.4.1131"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11248-008-9189-0"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2009.03.031"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhsb.2004.09.003"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1186\/1749-7221-4-11"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/micr.1920100315"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2012.07.026"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0270(01)00378-8"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1179\/016164104225013833"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1990.tb08180.x"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-9384(01)00527-3"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/neu.10173"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-2236(03)00033-X"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9384(95)00110-5"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0361-9230(99)00169-0"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-4328(97)00200-3"},{"key":"e_1_2_6_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/dev.1041"},{"key":"e_1_2_6_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aanat.2011.04.008"},{"key":"e_1_2_6_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2011.06.013"},{"key":"e_1_2_6_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2004.12.007"},{"key":"e_1_2_6_55_1","doi-asserted-by":"publisher","DOI":"10.1017\/CBO9780511541759"}],"container-title":["Journal of the Peripheral Nervous System"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjns5.12035","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjns5.12035","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jns5.12035","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T16:18:44Z","timestamp":1696263524000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jns5.12035"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,9]]},"references-count":54,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2013,9]]}},"alternative-id":["10.1111\/jns5.12035"],"URL":"https:\/\/doi.org\/10.1111\/jns5.12035","archive":["Portico"],"relation":{},"ISSN":["1085-9489","1529-8027"],"issn-type":[{"value":"1085-9489","type":"print"},{"value":"1529-8027","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,9]]}}}