{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T11:27:10Z","timestamp":1761823630718},"reference-count":12,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,12,12]],"date-time":"2013-12-12T00:00:00Z","timestamp":1386806400000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Peripheral Nervous Sys"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The role of carpal tunnel decompression surgery for patients that have hereditary neuropathy with liability to pressure palsy (<jats:styled-content style=\"fixed-case\">HNPP<\/jats:styled-content>) is currently unknown. Since recovery from carpal tunnel compression is often associated with remyelination or nodal reconstruction rather than axonal regeneration, it is uncertain whether the <jats:styled-content style=\"fixed-case\">PMP22<\/jats:styled-content> deletion associated with <jats:styled-content style=\"fixed-case\">HNPP<\/jats:styled-content> interrupts myelin or nodal reconstitution. We describe two patients with genetically confirmed <jats:styled-content style=\"fixed-case\">HNPP<\/jats:styled-content> and symptomatic carpal tunnel syndrome that had clinical and electrophysiological improvement after surgical decompression. The findings indicate a capacity for conduction repair in <jats:styled-content style=\"fixed-case\">HNPP<\/jats:styled-content>. They also suggest a need for further investigation and discussion around whether to offer carpal tunnel decompression to symptomatic <jats:styled-content style=\"fixed-case\">HNPP<\/jats:styled-content> patients.<\/jats:p>","DOI":"10.1111\/jns5.12047","type":"journal-article","created":{"date-parts":[[2013,10,31]],"date-time":"2013-10-31T09:52:35Z","timestamp":1383213155000},"page":"331-335","source":"Crossref","is-referenced-by-count":17,"title":["Is carpal tunnel decompression warranted for <scp>HNPP<\/scp>?"],"prefix":"10.1111","volume":"18","author":[{"given":"Nicholas","family":"Earle","sequence":"first","affiliation":[{"name":"Department of Clinical Neurosciences University of Calgary Calgary Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Douglas W.","family":"Zochodne","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurosciences University of Calgary Calgary Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,12,12]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.54.1.40"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000056044.69057.D3"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1529-8027.2012.00440.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.58.12.1769"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.10521"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-012-8370-x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(75)90263-4"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410360415"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02339245"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ncl.2013.01.009"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22166"},{"key":"e_1_2_6_13_1","first-page":"240","article-title":"Surgical treatment of a tomaculous neuropathy","volume":"46","author":"Taggart TF","year":"2001","journal-title":"J R Coll Surg Edinb"}],"container-title":["Journal of the Peripheral Nervous System"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjns5.12047","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjns5.12047","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jns5.12047","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T22:25:02Z","timestamp":1696199102000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jns5.12047"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,12]]},"references-count":12,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2013,12]]}},"alternative-id":["10.1111\/jns5.12047"],"URL":"https:\/\/doi.org\/10.1111\/jns5.12047","archive":["Portico"],"relation":{},"ISSN":["1085-9489","1529-8027"],"issn-type":[{"value":"1085-9489","type":"print"},{"value":"1529-8027","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,12]]}}}