{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T21:13:47Z","timestamp":1757452427393,"version":"3.37.3"},"reference-count":12,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,9,23]],"date-time":"2014-09-23T00:00:00Z","timestamp":1411430400000},"content-version":"vor","delay-in-days":114,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004386","name":"University of Malaya","doi-asserted-by":"crossref","award":["RG491\/13HTM"],"award-info":[{"award-number":["RG491\/13HTM"]}],"id":[{"id":"10.13039\/501100004386","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001349","name":"Singapore National Medical Research Council","doi-asserted-by":"crossref","award":["IRG 10nov086","CSA\/047\/2012"],"award-info":[{"award-number":["IRG 10nov086","CSA\/047\/2012"]}],"id":[{"id":"10.13039\/501100001349","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Yong Loo Lin School of Medicine"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Peripheral Nervous Sys"],"published-print":{"date-parts":[[2014,6]]},"abstract":"Abstract<\/jats:title>A close relationship between acute motor conduction block neuropathy and antibodies against the complex of GM1<\/jats:styled-content> and GalNAc\u2010GD1a<\/jats:styled-content> has been reported. This study investigates the hypothesis that conduction block at the early phase of axonal Guillain\u2010Barr\u00e9 syndrome (GBS) is also associated with such ganglioside complexes. Sera were obtained from seven French patients with initial evidence of isolated conduction blocks that resolved or progressed to acute motor axonal neuropathy. Serum IgG<\/jats:styled-content> to asialo\u2010GM1<\/jats:styled-content> and gangliosides of LM1<\/jats:styled-content>, GM1<\/jats:styled-content>, GM1b<\/jats:styled-content>, GD1a<\/jats:styled-content>, GalNAc\u2010GD1a<\/jats:styled-content>, GD1b<\/jats:styled-content>, GT1a<\/jats:styled-content>, GT1b<\/jats:styled-content>, and GQ1b<\/jats:styled-content> as well as their complexes were measured. Five of seven patients progressed within the first month of disease to AMAN. One patient had IgG<\/jats:styled-content> antibodies against the complex of asialo\u2010GM1<\/jats:styled-content> and each of the other ganglioside antigens. Another patient carried IgG<\/jats:styled-content> antibodies against GM1<\/jats:styled-content> complex with GM1b<\/jats:styled-content>, GD1a<\/jats:styled-content>, and GT1a<\/jats:styled-content> as well as asialo\u2010GM1<\/jats:styled-content> complex with GD1a<\/jats:styled-content> and GT1a<\/jats:styled-content>. None had IgG<\/jats:styled-content> antibodies against GM1<\/jats:styled-content>\/GalNAc\u2010GD1a<\/jats:styled-content> complex. Six patients had IgG<\/jats:styled-content> against single antigens GM1<\/jats:styled-content>, GD1a<\/jats:styled-content>, GalNAc\u2010GD1a<\/jats:styled-content>, GD1b<\/jats:styled-content>, and asialo\u2010GM1<\/jats:styled-content>. In three patients, a reduced reaction against GM1<\/jats:styled-content>\/GalNAc\u2010GD1a<\/jats:styled-content> complex was observed. The presence of conduction block in axonal GBS is not always associated with anti\u2010GM1<\/jats:styled-content>\/GalNAc\u2010GD1a<\/jats:styled-content> complex antibodies.<\/jats:p>","DOI":"10.1111\/jns5.12060","type":"journal-article","created":{"date-parts":[[2014,4,17]],"date-time":"2014-04-17T13:46:37Z","timestamp":1397742397000},"page":"115-120","source":"Crossref","is-referenced-by-count":11,"title":["Association of antibodies to ganglioside complexes and conduction blocks in axonal Guillain\u2010Barr\u00e9 syndrome presenting as acute motor conduction block neuropathy"],"prefix":"10.1111","volume":"19","author":[{"given":"Alain","family":"Cr\u00e9ange","sequence":"first","affiliation":[{"name":"EA 4391, Excitabilit\u00e9 Nerveuse et Th\u00e9rapeutique Universit\u00e9 Paris EST Cr\u00e9teil France"},{"name":"Service de Neurologie, Groupe Hospitalier Henri Mondor Assistance Publique\u2010H\u00f4pitaux de Paris Cr\u00e9teil France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nortina","family":"Shahrizaila","sequence":"additional","affiliation":[{"name":"Division of Neurology, Department of Medicine, Faculty of Medicine University of Malaya Kuala Lumpur Malaysia"},{"name":"Departments of Medicine and Physiology, Yong Loo Lin School of Medicine National University of Singapore Singapore Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hayet","family":"Salhi","sequence":"additional","affiliation":[{"name":"EA 4391, Excitabilit\u00e9 Nerveuse et Th\u00e9rapeutique Universit\u00e9 Paris EST Cr\u00e9teil France"},{"name":"Service de Neurologie, Groupe Hospitalier Henri Mondor Assistance Publique\u2010H\u00f4pitaux de Paris Cr\u00e9teil France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean\u2010Pascal","family":"Lefaucheur","sequence":"additional","affiliation":[{"name":"EA 4391, Excitabilit\u00e9 Nerveuse et Th\u00e9rapeutique Universit\u00e9 Paris EST Cr\u00e9teil France"},{"name":"Service de Physiologie\u2010Explorations Fonctionnelles, Groupe Hospitalier Henri Mondor Assistance Publique\u2010H\u00f4pitaux de Paris Cr\u00e9teil France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuhiro","family":"Yuki","sequence":"additional","affiliation":[{"name":"Departments of Medicine and Physiology, Yong Loo Lin School of Medicine National University of Singapore Singapore Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,9,23]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1529-8027.2010.00285.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.61.5.617"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2008.154351"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410440512"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1529-8027.2011.00314.x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000335160.72184.7d"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awq260"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2012.05.001"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2012.09.005"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.10317"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2011.11.039"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1586\/ern.09.43"}],"container-title":["Journal of the Peripheral Nervous System"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjns5.12060","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjns5.12060","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jns5.12060","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T11:08:11Z","timestamp":1696244891000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jns5.12060"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,6]]},"references-count":12,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,6]]}},"alternative-id":["10.1111\/jns5.12060"],"URL":"https:\/\/doi.org\/10.1111\/jns5.12060","archive":["Portico"],"relation":{},"ISSN":["1085-9489","1529-8027"],"issn-type":[{"type":"print","value":"1085-9489"},{"type":"electronic","value":"1529-8027"}],"subject":[],"published":{"date-parts":[[2014,6]]}}}