{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T04:53:49Z","timestamp":1790398429379,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,9,23]],"date-time":"2014-09-23T00:00:00Z","timestamp":1411430400000},"content-version":"vor","delay-in-days":114,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004243","name":"Prinses Beatrix Spierfonds","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004243","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100013428","name":"Stichting Spieren voor Spieren","doi-asserted-by":"crossref","award":["W.OR 12-04"],"award-info":[{"award-number":["W.OR 12-04"]}],"id":[{"id":"10.13039\/501100013428","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Nationaal Epilepsie Fonds, Hersenstichting and Sophia Foundation"},{"name":"Baxter International Inc."},{"DOI":"10.13039\/501100001826","name":"Netherlands Organization for Health Research and Development","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001826","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Erasmus MC"},{"DOI":"10.13039\/100013560","name":"GBS-CIDP Foundation International","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100013560","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Peripheral Nervous Sys"],"published-print":{"date-parts":[[2014,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The objective of this study is to determine the long\u2010term outcome and consequences of Guillain\u2010Barr\u00e9 syndrome (<jats:styled-content style=\"fixed-case\">GBS<\/jats:styled-content>) in children. This is an observational cross\u2010sectional cohort study of children diagnosed with <jats:styled-content style=\"fixed-case\">GBS<\/jats:styled-content> (0\u201318\u2009years old) at the Sophia Children's Hospital in Rotterdam from 1987 to 2009. All patients were invited for a structured interview, questionnaires, and full neurologic exam to record their current clinical condition focused on complaints and symptoms, neurological deficits, disabilities, behavior, and quality of life. Thirty\u2010seven patients participated, 23 were now adults, with a median age of 20\u2009years (range 4\u201339\u2009years) and a median follow\u2010up time of 11\u2009years (range 1\u201322\u2009years). Residual complaints were reported by 24 (65%) patients, including paresthesias (38%), unsteadiness of gait in the dark (37%), painful hands or feet (24%), and severe fatigue (22%). Four patients had severe neurological deficits, including facial diplegia and limb weakness. Two patients had had a recurrence of <jats:styled-content style=\"fixed-case\">GBS<\/jats:styled-content>. In 10 patients (26%), <jats:styled-content style=\"fixed-case\">GBS<\/jats:styled-content> had a negative impact on their school career. Questionnaires identified a wide range of behavioral problems. Quality of life was below normal on the subscale vitality, and above normal on the subscales social functioning and positive emotions in the adult group. Most children show good recovery of neurological deficits after <jats:styled-content style=\"fixed-case\">GBS<\/jats:styled-content>, but many have persisting long\u2010term residual complaints and symptoms that may lead to psychosocial problems interfering with participation in daily life.<\/jats:p>","DOI":"10.1111\/jns5.12068","type":"journal-article","created":{"date-parts":[[2014,5,23]],"date-time":"2014-05-23T11:42:43Z","timestamp":1400845363000},"page":"121-126","source":"Crossref","is-referenced-by-count":53,"title":["Long\u2010term outcome of Guillain\u2010Barr\u00e9 syndrome in\u00a0children"],"prefix":"10.1111","volume":"19","author":[{"given":"Joyce","family":"Roodbol","sequence":"first","affiliation":[{"name":"Department of Pediatric Neurology, Erasmus MC and Erasmus MC\u2010Sophia Children's Hospital University Medical Center Rotterdam  Rotterdam The Netherlands"},{"name":"Department of Neurology, Erasmus MC and Erasmus MC\u2010Sophia Children's Hospital University Medical Center Rotterdam  Rotterdam The Netherlands"},{"name":"Department of Immunology, Erasmus MC and Erasmus MC\u2010Sophia Children's Hospital University Medical Center Rotterdam  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie\u2010Claire Y.","family":"de Wit","sequence":"additional","affiliation":[{"name":"Department of Pediatric Neurology, Erasmus MC and Erasmus MC\u2010Sophia Children's Hospital University Medical Center Rotterdam  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Femke K.","family":"Aarsen","sequence":"additional","affiliation":[{"name":"Department of Pediatric Neurology, Erasmus MC and Erasmus MC\u2010Sophia Children's Hospital University Medical Center Rotterdam  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Coriene E.","family":"Catsman\u2010Berrevoets","sequence":"additional","affiliation":[{"name":"Department of Pediatric Neurology, Erasmus MC and Erasmus MC\u2010Sophia Children's Hospital University Medical Center Rotterdam  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bart C.","family":"Jacobs","sequence":"additional","affiliation":[{"name":"Department of Neurology, Erasmus MC and Erasmus MC\u2010Sophia Children's Hospital University Medical Center Rotterdam  Rotterdam The Netherlands"},{"name":"Department of Immunology, Erasmus MC and Erasmus MC\u2010Sophia Children's Hospital University Medical Center Rotterdam  Rotterdam The 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