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As adolescents prioritize confidentiality and accessibility, digital interventions are becoming increasingly relevant in sex education. We therefore posed the following research question: Are digital application interventions effective to prevent risky sexual behaviors in school adolescents?<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>A systematic peer review was conducted between January and December 2023 in five databases (PubMed, Web of Science, Scopus, EMBASE, and PsycINFO) without restricting for language or year of publication.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>We included randomized control trials or quasi\u2010experimental studies that measured the effectiveness of interventions targeting young people aged 10\u201319\u2009years or their parents and developed in a school setting. Interventions aimed at young people with intellectual disabilities, learning difficulties, or any disease requiring a specific intervention were excluded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The search ultimately yielded 27 studies covering a total of 18 digital interventions that demonstrated positive effects, not maintained over time, on knowledge, attitudes, and behaviors, although the latter to a lesser extent.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>We have found very interesting digital interventions with effects, among others, on knowledge, attitudes, and contraceptive use in adolescents. In general, digital interventions have positive effects on knowledge and attitudes, but it is more difficult to modify behaviors with strictly digital interventions or combined with complementary face\u2010to\u2010face sessions or group class activities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We thus believe that digital interventions are adequate to reduce adolescent sexual risk behaviors, and our systematic review facilitates the implementation of these interventions by sharing existing digital interventions that have had positive effects, as well as the main characteristics a digital intervention should possess to reduce sexually risky behaviors in adolescents.<\/jats:p><\/jats:sec><jats:sec><jats:title>Clinical relevance<\/jats:title><jats:p>Digital interventions with adolescents improve sexual behaviors and can be a valuable resource in education on this topic due to their accessibility and confidentiality, two key points for young people.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jnu.13015","type":"journal-article","created":{"date-parts":[[2024,8,9]],"date-time":"2024-08-09T04:38:20Z","timestamp":1723178300000},"page":"342-353","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Effectiveness of digital interventions to reduce school\u2010age adolescent sexual risks: A systematic review"],"prefix":"10.1111","volume":"57","author":[{"given":"Ana","family":"Aguilar\u2010Quesada","sequence":"first","affiliation":[{"name":"Hospital Universitario San Cecilio  Granada Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alba","family":"Sierra\u2010Yag\u00fce","sequence":"additional","affiliation":[{"name":"Catalan Institute of Health  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"Gonz\u00e1lez\u2010Cano\u2010Caballero","sequence":"additional","affiliation":[{"name":"Department of Nursing, Faculty of Health Sciences University of Granada  Granada Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Antonio","family":"Zafra\u2010Egea","sequence":"additional","affiliation":[{"name":"Department of Nursing of the Faculty of Health Sciences of UManresa Fundaci\u00f3 Universit\u00e0ria del Bages, University of Vic, Central University of Catalonia  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Lima\u2010Serrano","sequence":"additional","affiliation":[{"name":"Department of Nursing, School of Nursing, Physiotherapy, and Podiatry University of Seville  Seville Spain"},{"name":"Institute of Biomedicine of Seville (IBiS)  Sevilla Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,8,8]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/GCO.0000000000000485"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/09540121.2015.1073663"},{"key":"e_1_2_9_4_1","doi-asserted-by":"crossref","unstructured":"Chong A. 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