{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T10:46:22Z","timestamp":1775731582500,"version":"3.50.1"},"reference-count":53,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T00:00:00Z","timestamp":1769212800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T00:00:00Z","timestamp":1769212800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100019004","name":"Deanship of Research, Jordan University of Science and Technology","doi-asserted-by":"publisher","award":["7797448"],"award-info":[{"award-number":["7797448"]}],"id":[{"id":"10.13039\/501100019004","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["sigmapubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Nursing Scholarship"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Clinical nurses face notable chronic stress due to work\u2010related stressors, exacerbated by the COVID\u201019 pandemic, leading to somatic symptoms and low\u2010grade inflammation. Mindfulness meditation has shown promise in reducing stress and improving health outcomes, but its effects on somatic symptoms and inflammatory biomarkers in nurses remain underexplored.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To assess the impact of mindfulness meditation on somatic symptoms and inflammatory biomarkers such as leptin, interleukin\u20106, and tumor necrosis factor\u2010\u03b1 among nurses. To explore the secondary effects on perceived stress and trait mindfulness because of the complex interlinked association with the primary outcomes of interest.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methodology<\/jats:title>\n                    <jats:p>A randomized controlled trial was conducted with 102 nurses randomly assigned to a meditation group (8\u2010week mindfulness meditation program) or a non\u2010meditation group. Data were collected using self\u2010report questionnaires (Mindfulness Attention Awareness Scale, Perceived Stress Scale, Patient Health Questionnaire\u201015) and blood samples for biomarker analysis at baseline and post\u2010intervention.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Findings<\/jats:title>\n                    <jats:p>\n                      The meditation group demonstrated notable reductions in perceived stress (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), somatic symptoms (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), IL\u20106 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), and leptin levels (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) compared to the non\u2010meditation group. Trait mindfulness increased markedly in the meditation group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.003), while TNF\u2010\u03b1 levels did not show notable changes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Concluding Remark<\/jats:title>\n                    <jats:p>Mindfulness meditation efficiently reduces perceived stress, somatic symptoms, and inflammatory biomarkers in nurses, highlighting its potential as a holistic intervention to improve both psychological and physical well\u2010being in high\u2010stress healthcare environments.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>ClinicalTrail.gove, NCT06635278<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jnu.70067","type":"journal-article","created":{"date-parts":[[2026,1,25]],"date-time":"2026-01-25T04:48:11Z","timestamp":1769316491000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Impact of Mindfulness Meditation on Perceived Stress, Somatic Symptoms and Inflammatory Biomarkers Among Clinical Nurses"],"prefix":"10.1111","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6370-8311","authenticated-orcid":false,"given":"Hossam","family":"Alhawatmeh","sequence":"first","affiliation":[{"name":"Adult Health Nursing Department, College of Nursing Jordan University of Science and Technology  Irbid Jordan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luay","family":"Abusaif","sequence":"additional","affiliation":[{"name":"Community and Mental Health Nursing Department College of Nursing, Jordan University of Science  Irbid Jordan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maryam","family":"Alharrasi","sequence":"additional","affiliation":[{"name":"Adult Health Nursing Department, College of Nursing Sultan Qaboos University  Muscat Oman"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5817-8950","authenticated-orcid":false,"given":"Sawsan","family":"Abuhammad","sequence":"additional","affiliation":[{"name":"Department of Nursing College of Health Sciences, University of Sharjah  Sharjah UAE"},{"name":"Department of Maternal and Child Health, Faculty of Nursing Jordan University of Science and Technology  Irbid Jordan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,1,24]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0334603"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.2147\/JMDH.S269511"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12905-021-01390-6"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12991-017-0155-1"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2022.e11147"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.2147\/AMEP.S348062"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijnurstu.2011.07.012"},{"issue":"3","key":"e_1_2_11_9_1","article-title":"Primer for Mainstreaming Mind\u2010Body Techniques for Extreme Climates\u2010Insights and Future Directions","volume":"7","author":"Anand A.","year":"2020","journal-title":"Medicines (Basel)"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12912\u2010022\u201000852\u2010y"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2021.724126"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1037\/0022-3514.84.4.822"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.5402\/2012\/651583"},{"issue":"2","key":"e_1_2_11_14_1","first-page":"1","article-title":"Stress Management Interventions Among Healthcare Workers Using Mindfulness: A Systematic Review","volume":"5","author":"Chiappetta M.","year":"2018","journal-title":"Senses and Sciences"},{"key":"e_1_2_11_15_1","first-page":"15","volume-title":"Leucocytes: Methods and Protocols","author":"Chiswick E. L.","year":"2011"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.2307\/2136404"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.3233\/WOR-2001-00148"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijnurstu.2016.10.002"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1080\/87568225.2016.1140988"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.4103\/JNMS.JNMS_98_20"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.3758\/BF03193146"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-019-0675-0"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12671-011-0043-8"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12671-015-0444-1"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1590\/1516-3180.2020.0722.r1.2302021"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0274202"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.genhosppsych.2013.04.006"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.2147\/JMDH.S330041"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006842-200203000-00008"},{"key":"e_1_2_11_30_1","volume-title":"Stress, Appraisal, and Coping","author":"Lazarus R. S.","year":"1984"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1177\/2165079918801633"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12671\u2010018\u20101062\u20105"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2016.0013"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2022.996559"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1097\/HNP.0000000000000466"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/appy.12427"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocn.16265"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12912\u2010024\u201002616\u20102"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apnu.2018.01.001"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41574-019-0228-0"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12906-017-1638-y"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnbeh.2020.601939"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2019.101493"},{"key":"e_1_2_11_44_1","volume-title":"Relaxation, Meditation, & Mindfulness: A Mental Health Practitioner's Guide to New and Traditional Approaches","author":"Smith J. C.","year":"2005"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.3889\/oamjms.2018.100"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10354\u2010017\u20100574\u20102"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apnr.2022.151565"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1177\/10398562231156380"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-psych-010418-102936"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nedt.2018.03.018"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1037\/ccp0000122"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.2991\/978-2-38476-032-9_35"},{"key":"e_1_2_11_53_1","first-page":"1057","article-title":"The Impact of Stress on Body Function: A Review","volume":"16","author":"Yaribeygi H.","year":"2017","journal-title":"EXCLI Journal"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12671-022-01960-1"}],"container-title":["Journal of Nursing Scholarship"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/sigmapubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jnu.70067","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/sigmapubs.onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jnu.70067","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/sigmapubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jnu.70067","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T09:47:45Z","timestamp":1775728065000},"score":1,"resource":{"primary":{"URL":"https:\/\/sigmapubs.onlinelibrary.wiley.com\/doi\/10.1111\/jnu.70067"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,24]]},"references-count":53,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10.1111\/jnu.70067"],"URL":"https:\/\/doi.org\/10.1111\/jnu.70067","archive":["Portico"],"relation":{},"ISSN":["1527-6546","1547-5069"],"issn-type":[{"value":"1527-6546","type":"print"},{"value":"1547-5069","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,24]]},"assertion":[{"value":"2025-11-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-24","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70067"}}