{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T06:49:30Z","timestamp":1791528570023,"version":"4.3.4"},"reference-count":36,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:00:00Z","timestamp":1791417600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:00:00Z","timestamp":1791417600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["sigmapubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Nursing Scholarship"],"published-print":{"date-parts":[[2026,11]]},"abstract":"ABSTRACT<\/jats:title>\n \n Aims<\/jats:title>\n To systematically evaluate the incidence and influencing factors of pain crisis in cancer patients, providing evidence for targeted preventive interventions and optimized clinical nursing strategies.<\/jats:p>\n <\/jats:sec>\n \n Design<\/jats:title>\n A systematic review and meta\u2010analysis following PRISMA guidelines.<\/jats:p>\n <\/jats:sec>\n \n Data Sources<\/jats:title>\n PubMed, Cochrane Library, Web of Science, CINAHL, Embase, SinoMed, CNKI, Wanfang, and VIP were searched from inception to February 2026.<\/jats:p>\n <\/jats:sec>\n \n Review Methods<\/jats:title>\n \n Literature screening, quality assessment, and data extraction were performed independently by two researchers. Meta\u2010analysis was conducted using RevMan 5.4. Heterogeneity was assessed using the\n I<\/jats:italic>\n 2<\/jats:sup>\n statistic, and effect sizes were expressed as odds ratios (ORs) with 95% confidence intervals (CIs).\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Seven studies involving 1865 cancer patients were included. The pooled incidence of pain crisis was 37%. Significant influencing factors included bone metastasis (OR\u2009=\u20093.91), radiotherapy and chemotherapy (OR\u2009=\u20093.23), social support (OR\u2009=\u20090.88), and age (OR\u2009=\u20090.92). Anxiety (mild OR\u2009=\u20098.00, moderate OR\u2009=\u20099.15, severe OR\u2009=\u200910.99) and depression (mild OR\u2009=\u20096.54, moderate OR\u2009=\u20096.46) were also significant predictors.<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n The incidence of pain crisis in cancer patients is relatively high and is influenced by bone metastasis, chemoradiotherapy, social support, age, and emotional states. Nurses should dynamically assess risk, identify factors, and implement individualized interventions to prevent pain crisis and improve quality of life.<\/jats:p>\n <\/jats:sec>\n \n Impact<\/jats:title>\n This meta\u2010analysis provides robust evidence for identifying high\u2010risk cancer patients for pain crisis. The findings underscore the need for integrating routine psychological assessment and tailored pain management strategies into clinical oncology nursing practice to reduce the occurrence of pain crises and enhance patient well\u2010being.<\/jats:p>\n <\/jats:sec>\n \n Patient or Public Contribution<\/jats:title>\n Not applicable.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jnu.70145","type":"journal-article","created":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T05:55:38Z","timestamp":1791525338000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Incidence and Influencing Factors of Pain Crisis in Cancer Patients: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1111","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-7118-751X","authenticated-orcid":false,"given":"Fengjuan","family":"Wang","sequence":"first","affiliation":[{"name":"Shenzhen Longhua District Central Hospital Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huifen","family":"Tong","sequence":"additional","affiliation":[{"name":"Shenzhen Longhua District Central Hospital Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Limei","family":"Gao","sequence":"additional","affiliation":[{"name":"Shenzhen Longhua District Central Hospital Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gantang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Shenzhen Longhua District Central Hospital Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,8]]},"reference":[{"issue":"36","key":"e_1_2_15_2_1","first-page":"3148","article-title":"Chinese Guidelines for Cancer Pain Management in Adults (2025 Edition)","volume":"105","author":"Cancer Pain Integration Therapy Professional Committee of the China Anti\u2011Cancer Association","year":"2025","journal-title":"National Medical Journal of China"},{"issue":"11","key":"e_1_2_15_3_1","first-page":"1341","article-title":"Expert Consensus on Adult Cancer Pain Care in Anhui Province","volume":"45","author":"Cancer Pain Nursing Specialty Alliance Expert Group of Anhui","year":"2024","journal-title":"Anhui Medical Journal"},{"issue":"21","key":"e_1_2_15_4_1","first-page":"1591","article-title":"Expert Recommendations on the Formation of Pain Crisis Concept and Management Plan in Cancer Pain Management","volume":"103","author":"Chinese Society of Clinical Oncology\u2011Supportive Care and Rehabilitation Committee","year":"2023","journal-title":"National Medical Journal of China"},{"issue":"2","key":"e_1_2_15_5_1","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.jpeds.2011.07.018","article-title":"Markers of Severe Vaso\u2010Occlusive Painful Episode Frequency in Children and Adolescents With Sickle Cell Anemia","volume":"160","author":"Darbari D. S.","year":"2012","journal-title":"Journal of Pediatrics"},{"issue":"3","key":"e_1_2_15_6_1","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1111\/ejh.13430","article-title":"The Vaso\u2010Occlusive Pain Crisis in Sickle Cell Disease: Definition, Pathophysiology, and Management","volume":"105","author":"Darbari D. S.","year":"2020","journal-title":"European Journal of Haematology"},{"issue":"1","key":"e_1_2_15_7_1","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1360\/SSV-2025-0072","article-title":"Investigation of Self\u2010Reported Pain in Chinese Patients With Common Cancer","volume":"56","author":"Deng L.","year":"2026","journal-title":"Scientia Sinica Vitae"},{"issue":"11","key":"e_1_2_15_8_1","first-page":"1477","article-title":"Occurrence of Pain Crisis in Postoperative Patients With Colorectal Cancer and the Influencing Factors","volume":"45","author":"Dou L. Y.","year":"2025","journal-title":"Journal of Pathology: Clinical Research"},{"issue":"11","key":"e_1_2_15_9_1","first-page":"1353","article-title":"Status Quo and Influencing Factors of Pain Crisis in Advanced Lung Cancer Patient","volume":"59","author":"Dou L. Y.","year":"2024","journal-title":"Chinese Journal of Nursing"},{"issue":"3","key":"e_1_2_15_10_1","doi-asserted-by":"crossref","first-page":"326","DOI":"10.15537\/1658-3175.8333","article-title":"Global Cancer Burden Growing, Amidst Mounting Need for Services","volume":"45","author":"International Agency for Research on Cancer","year":"2024","journal-title":"Saudi Medical Journal"},{"key":"e_1_2_15_11_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejon.2025.102978","article-title":"Cancer Pain Experiences in Adult Patients With Cancer: A Qualitative Meta\u2010Ethnography","volume":"78","author":"Jeong Y.","year":"2025","journal-title":"European Journal of Oncology Nursing"},{"issue":"3","key":"e_1_2_15_12_1","first-page":"481","article-title":"Prevalence and Correlation of Pain Crisis and Cancer\u2010Related Fatigue in Elderly Patients With Malignant Tumor","volume":"27","author":"Jiang Y.","year":"2025","journal-title":"Chinese Journal of Health Management"},{"key":"e_1_2_15_13_1","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2023.1156618","article-title":"Management of Pain in Patients With Bone Metastases","volume":"13","author":"Jing D.","year":"2023","journal-title":"Frontiers in Oncology"},{"issue":"1","key":"e_1_2_15_14_1","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1186\/s12904-026-02013-3","article-title":"Prevalence of Acute Pain Crisis in Patients With Cancer in Specialist Palliative Care Clinic: An Observational Study","volume":"25","author":"Kamble S.","year":"2026","journal-title":"BMC Palliative Care"},{"issue":"8","key":"e_1_2_15_15_1","doi-asserted-by":"crossref","first-page":"1908","DOI":"10.1182\/bloodadvances.2023010749","article-title":"Incidence and Risk Factors of Pain Crisis After Hematopoietic Cell Transplantation for Sickle Cell Disease","volume":"8","author":"Krishnamurti L.","year":"2024","journal-title":"Blood Advances"},{"issue":"8","key":"e_1_2_15_16_1","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1080\/13803395.2025.2539199","article-title":"Neurotoxicity of Chemotherapy and Brain\u2010Radiotherapy in Cancer: Overlapping Mechanisms Underlying Cognitive Impairment","volume":"47","author":"Kuil L. E.","year":"2025","journal-title":"Journal of Clinical and Experimental Neuropsychology"},{"issue":"17","key":"e_1_2_15_17_1","first-page":"3342","article-title":"Research Progress of the Role of Tumor Microenvironment in Neuropathic Cancer Pain","volume":"32","author":"Liu M. L.","year":"2024","journal-title":"Modern Oncology"},{"issue":"12","key":"e_1_2_15_18_1","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1001\/jama.299.12.1457","article-title":"Managing an Acute Pain Crisis in a Patient With Advanced Cancer: \u2018This Is as Much of a Crisis as a Code\u2019","volume":"299","author":"Moryl N.","year":"2008","journal-title":"JAMA"},{"issue":"6","key":"e_1_2_15_19_1","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1111\/papr.13220","article-title":"Associations Between Chronic Pain, Anxiety, and Depression Among Adults in the United States","volume":"23","author":"Mullins P. M.","year":"2023","journal-title":"Pain Practice"},{"key":"e_1_2_15_20_1","doi-asserted-by":"crossref","DOI":"10.3389\/fpsyg.2022.960049","article-title":"The Effectiveness of Supportive Psychotherapy on the Anxiety and Depression Experienced by Patients Receiving Fiberoptic Bronchoscope","volume":"13","author":"Ren F.","year":"2022","journal-title":"Frontiers in Psychology"},{"issue":"2","key":"e_1_2_15_21_1","doi-asserted-by":"crossref","first-page":"210","DOI":"10.4103\/0973-1075.285687","article-title":"Indian Society for Study of Pain, Cancer Pain Special Interest Group Guidelines on Palliative Care Aspects in Cancer Pain Management","volume":"26","author":"Salins N.","year":"2020","journal-title":"Indian Journal of Palliative Care"},{"issue":"5","key":"e_1_2_15_22_1","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.jpainsymman.2025.07.030","article-title":"Depression and Cancer Pain: Mediating Roles of Anxiety and Pain Beliefs","volume":"70","author":"Shim E. J.","year":"2025","journal-title":"Journal of Pain and Symptom Management"},{"issue":"1","key":"e_1_2_15_23_1","first-page":"10","article-title":"Cancer Statistics, 2025","volume":"75","author":"Siegel R. L.","year":"2025","journal-title":"CA: A Cancer Journal for Clinicians"},{"issue":"3","key":"e_1_2_15_24_1","doi-asserted-by":"crossref","first-page":"591","DOI":"10.3390\/cancers15030591","article-title":"Update on Prevalence of Pain in Patients With Cancer 2022: A Systematic Literature Review and Meta\u2010Analysis","volume":"15","author":"Snijders R. A. H.","year":"2023","journal-title":"Cancers"},{"issue":"9","key":"e_1_2_15_25_1","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1007\/s10654-010-9491-z","article-title":"Critical Evaluation of the Newcastle\u2013Ottawa Scale for the Assessment of the Quality of Nonrandomized Studies in Meta\u2010Analyses","volume":"25","author":"Stang A.","year":"2010","journal-title":"European Journal of Epidemiology"},{"issue":"7","key":"e_1_2_15_26_1","doi-asserted-by":"crossref","DOI":"10.6004\/jnccn.2025.0032","article-title":"Adult Cancer Pain, Version 2.2025, NCCN Clinical Practice Guidelines in Oncology","volume":"23","author":"Swarm R. A.","year":"2025","journal-title":"Journal of the National Comprehensive Cancer Network"},{"issue":"3","key":"e_1_2_15_27_1","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1007\/s00774-022-01382-y","article-title":"Management of Cancer Pain due to Bone Metastasis","volume":"41","author":"Takei D.","year":"2023","journal-title":"Journal of Bone and Mineral Metabolism"},{"issue":"1","key":"e_1_2_15_28_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.pathol.2016.10.002","article-title":"Sickle Cell Disease in the Older Adult","volume":"49","author":"Thein M. S.","year":"2017","journal-title":"Pathology"},{"issue":"6","key":"e_1_2_15_29_1","first-page":"4408","article-title":"Standardized Nursing Mode Effectively Controls Pain Caused by Radiotherapy and Chemotherapy in Patients With Advanced Cancer","volume":"15","author":"Wang Q.","year":"2023","journal-title":"American Journal of Translational Research"},{"key":"e_1_2_15_30_1","doi-asserted-by":"crossref","DOI":"10.3389\/fpsyg.2025.1547999","article-title":"Cognitive Behavioral Therapy's Impact on Anxiety, Depression, and Quality of Life in Patients With Head and Neck Cancer: A Systematic Review","volume":"16","author":"Wang X.","year":"2025","journal-title":"Frontiers in Psychology"},{"issue":"30","key":"e_1_2_15_31_1","first-page":"34","article-title":"Analysis of the Current Situation and Influencing Factors of Pain Crisis in Patients With Advanced Colorectal Cancer. China Modern","volume":"63","author":"Xie T. Y.","year":"2025","journal-title":"Doctor"},{"issue":"4","key":"e_1_2_15_32_1","first-page":"372","article-title":"Mechanisms of Tumor Immune Microenvironment Remodeling in Current Cancer Therapies and the Research Progress","volume":"41","author":"Yang Y. Z.","year":"2025","journal-title":"Chinese Journal of Cellular and Molecular Immunology"},{"issue":"10","key":"e_1_2_15_33_1","first-page":"727","article-title":"Construction and Validation of a Nomogram Prediction Model for Pain Crisis Occurrence in Patients With Advanced Non\u2010Small Cell Lung Cancer","volume":"24","author":"Yu Y. S.","year":"2025","journal-title":"Chinese Journal of Respiratory and Critical Care Medicine"},{"issue":"4","key":"e_1_2_15_34_1","first-page":"297","article-title":"Meta\u2010Analysis Series IV: Quality Assessment Tools for Observational Studies","volume":"4","author":"Zeng X. T.","year":"2012","journal-title":"Chinese Journal of Evidence\u2010Based Cardiovascular Medicine"},{"issue":"1","key":"e_1_2_15_35_1","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-023-29167-x","article-title":"Long\u2010Term Survival and Second Malignant Tumor Prediction in Pediatric, Adolescent, and Young Adult Cancer Survivors Using Random Survival Forests: A SEER Analysis","volume":"13","author":"Zhang I. Y.","year":"2023","journal-title":"Scientific Reports"},{"issue":"8","key":"e_1_2_15_36_1","first-page":"11","article-title":"Construction of A Risk Prediction Model for Pain Crisis in Late\u2010Stage Lung Cancer Patients Based on the Random Forest Algorithm","volume":"34","author":"Zhang J. X.","year":"2025","journal-title":"Chinese Journal of Convalescent Medicine"},{"issue":"17","key":"e_1_2_15_37_1","first-page":"2900","article-title":"Construction of a Prediction Model for Pain Crisis in Patients With Advanced Rectal Cancer Based on Machine Learning Algorithm","volume":"39","author":"Zhang L. D.","year":"2025","journal-title":"Chinese Nursing Research"}],"container-title":["Journal of Nursing Scholarship"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/sigmapubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jnu.70145","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/sigmapubs.onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jnu.70145","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/sigmapubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jnu.70145","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T05:55:45Z","timestamp":1791525345000},"score":1,"resource":{"primary":{"URL":"https:\/\/sigmapubs.onlinelibrary.wiley.com\/doi\/10.1111\/jnu.70145"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,8]]},"references-count":36,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,11]]}},"alternative-id":["10.1111\/jnu.70145"],"URL":"https:\/\/doi.org\/10.1111\/jnu.70145","archive":["Portico"],"relation":{},"ISSN":["1527-6546","1547-5069"],"issn-type":[{"value":"1527-6546","type":"print"},{"value":"1547-5069","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,8]]},"assertion":[{"value":"2026-07-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70145"}}