{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T22:21:22Z","timestamp":1791066082876,"version":"4.1.0"},"reference-count":28,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,1,15]],"date-time":"2013-01-15T00:00:00Z","timestamp":1358208000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"the Agence Nationale de la Recherche","award":["ANR-07-MRAR-003"],"award-info":[{"award-number":["ANR-07-MRAR-003"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Anatomy"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Outflow tract defects, including cardiac neural crest defects (so\u2010called conotruncal defects) and transposition of the great arteries, are due to an abnormal rotation of the outflow tract during cardiac development. Coronary orifices are often abnormal in outflow tract defects, particularly in common arterial trunk (<jats:styled-content style=\"fixed-case\">CAT<\/jats:styled-content>). A recent study indicates that abnormal coronary artery pattern in a mouse model with common arterial outlet (<jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>bx1\u2212\/\u2212 mouse mutant) could be due to a reduced and malpositioned subpulmonary coronary\u2010refractory myocardial domain. The aim of our study was to demonstrate the relation between coronary orifices pattern in outflow tract defects in human and the abnormal embryonic rotation of the outflow tract. We analyzed 101 heart specimens with outflow tract defects: 46 <jats:styled-content style=\"fixed-case\">CAT<\/jats:styled-content>, 15 tetralogy of <jats:styled-content style=\"fixed-case\">F<\/jats:styled-content>allot (<jats:styled-content style=\"fixed-case\">TOF<\/jats:styled-content>), 29 <jats:styled-content style=\"fixed-case\">TOF<\/jats:styled-content> with pulmonary atresia (<jats:styled-content style=\"fixed-case\">TOF<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">PA<\/jats:styled-content>), 11 double\u2010outlet right ventricle with subaortic ventricular septal defect (<jats:styled-content style=\"fixed-case\">DORV<\/jats:styled-content>) and 17 controls. The position of left and right coronary orifices (<jats:styled-content style=\"fixed-case\">LCO<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> RCO<\/jats:styled-content>) was measured in degrees on the aortic\/truncal circumference. The anterior angle between <jats:styled-content style=\"fixed-case\">LCO<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">RCO<\/jats:styled-content> (\u03b1) was calculated. The <jats:styled-content style=\"fixed-case\">LCO<\/jats:styled-content> was more posterior in <jats:styled-content style=\"fixed-case\">TOF<\/jats:styled-content> (31\u2005\u00b0), <jats:styled-content style=\"fixed-case\">TOF<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">PA<\/jats:styled-content> (47\u2005\u00b0), <jats:styled-content style=\"fixed-case\">DORV<\/jats:styled-content> (44\u2005\u00b0), <jats:styled-content style=\"fixed-case\">CAT<\/jats:styled-content> (63\u2005\u00b0), compared with controls (0\u2005\u00b0, <jats:italic>P\u2005<\/jats:italic>&lt;\u20050.05), and more posterior in <jats:styled-content style=\"fixed-case\">CAT<\/jats:styled-content> than in other outflow tract defects (<jats:italic>P\u2005<\/jats:italic>&lt;\u20050.05). The <jats:styled-content style=\"fixed-case\">RCO<\/jats:styled-content> was more anterior in <jats:styled-content style=\"fixed-case\">TOF<\/jats:styled-content> (242\u2005\u00b0), <jats:styled-content style=\"fixed-case\">TOF<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">PA<\/jats:styled-content> (245\u2005\u00b0) and <jats:styled-content style=\"fixed-case\">DORV<\/jats:styled-content> (271\u2005\u00b0) than in controls (213\u2005\u00b0, <jats:italic>P\u2005<\/jats:italic>&lt;\u20050.05), but not in <jats:styled-content style=\"fixed-case\">CAT<\/jats:styled-content> (195\u2005\u00b0). The \u03b1 angle was similar in <jats:styled-content style=\"fixed-case\">TOF<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> TOF<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">PA<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> DORV<\/jats:styled-content> and controls (149\u2005\u00b0, 162\u2005\u00b0, 133\u2005\u00b0, 147\u2005\u00b0), but significantly larger in <jats:styled-content style=\"fixed-case\">CAT<\/jats:styled-content> (229\u2005\u00b0, <jats:italic>P\u2005<\/jats:italic>&lt;\u20050.0001). In all outflow tract defects but <jats:styled-content style=\"fixed-case\">CAT<\/jats:styled-content>, the displacement of <jats:styled-content style=\"fixed-case\">LCO<\/jats:styled-content> (anterior) and <jats:styled-content style=\"fixed-case\">RCO<\/jats:styled-content> (posterior), while the \u03b1 angle remains constant, might be due to incomplete rotation of the myocardium at the base of the outflow tract, leading to an abnormally positioned subpulmonary coronary\u2010refractory myocardial domain. The larger \u03b1 angle in <jats:styled-content style=\"fixed-case\">CAT<\/jats:styled-content> could reflect its dual identity, aortic and pulmonary.<\/jats:p>","DOI":"10.1111\/joa.12023","type":"journal-article","created":{"date-parts":[[2013,1,15]],"date-time":"2013-01-15T11:14:38Z","timestamp":1358248478000},"page":"349-357","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["The pattern of the coronary arterial orifices in hearts with congenital malformations of the outflow tracts: a marker of rotation of the outflow tract during cardiac development?"],"prefix":"10.1111","volume":"222","author":[{"given":"Lucile","family":"Houyel","sequence":"first","affiliation":[{"name":"H\u00f4pital Marie\u2010Lannelongue CMR\u2010M3C Universit\u00e9 Paris\u2010Sud Le Plessis\u2010Robinson 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