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The mechanisms leading to such abnormal skeletal growth and the involvement of the fibrillins are not understood. Postnatal longitudinal bone growth mainly occurs in the epiphyseal growth plate. Here we investigated the organisation of fibrillin microfibrils in the growth plate of the long bone and vertebra immunohistochemically. Fibrillin\u20101 was dual\u2010immunostained with elastin, with fibrillin\u20102 or with collagen X. We report that fibrillin microfibrils are distributed throughout all regions of the growth plate, and that fibrillin\u20101 and fibrillin\u20102 were differentially organised. Fibrillin\u20101 was more abundant in the extracellular matrix of the resting and proliferative zones of the growth plate than in the hypertrophic zone. More fibrillin\u20102 was found in the calcified region than in the other regions. No elastin fibres were observed in either the proliferative or hypertrophic zones. This study indicates that, as fibrillin microfibrils are involved in growth factor binding and may play a mechanical role, they could be directly involved in regulating bone growth. Hence, mutations of the fibrillins could affect their functional role in growth and lead to the growth disorders seen in patients with <jats:styled-content style=\"fixed-case\">MFS<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> CCA<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> AD<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> GD<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">WMS<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/joa.12123","type":"journal-article","created":{"date-parts":[[2013,10,12]],"date-time":"2013-10-12T02:29:17Z","timestamp":1381544957000},"page":"641-650","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Immunolocalisation of fibrillin microfibrils in the calf metacarpal and vertebral growth 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