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Periosteum comprises a cellular cambium layer directly apposing the outer surface of bone and an outer fibrous layer encompassed by the surrounding soft tissues. As a first step to elucidating the structural and cellular characteristics of periosteum in human bone, the current study aims to measure cambium and fibrous layer thickness as well as cambium cellularity in human femora and tibiae of aged donors. The major and minor centroidal axes (<jats:styled-content style=\"fixed-case\">CA<\/jats:styled-content>) serve as automated reference points in cross\u2010sections of cadaveric mid\u2010diaphyseal femora and tibiae. Based on the results of this study, within a given individual, the cambium layer of the major <jats:styled-content style=\"fixed-case\">CA<\/jats:styled-content> of the tibia is significantly thicker and more cellular than the respective layer of the femur. These significant intraindividual differences do not translate to significant interindividual differences. Further, mid\u2010diaphyseal periosteal measures including cambium and fibrous layer thickness and cellularity do not correlate significantly with age or body mass. Finally, qualitative observations of periosteum in amputated and contralateral or proximal long bones of the lower extremity show stark changes in layer organization, thickness, and cellularity. In a translational context, these novel data, though inherently limited by availability and accessibility of human mid\u2010diaphyseal periosteum tissue, provide important reference values for the use of periosteum in the context of facilitated healing and regeneration of tissue.<\/jats:p>","DOI":"10.1111\/joa.12133","type":"journal-article","created":{"date-parts":[[2013,11,1]],"date-time":"2013-11-01T08:02:07Z","timestamp":1383292927000},"page":"142-149","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Periosteal thickness and cellularity in mid\u2010diaphyseal cross\u2010sections from human femora and tibiae of aged donors"],"prefix":"10.1111","volume":"224","author":[{"given":"Shannon R.","family":"Moore","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering Case Western Reserve University Cleveland OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Milz","sequence":"additional","affiliation":[{"name":"Institute for Anatomy Ludwig Maximilians University Munich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melissa L.","family":"Knothe Tate","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering Case Western Reserve University Cleveland OH USA"},{"name":"Department of Mechanical &amp; Aerospace Engineering Case Western Reserve University Cleveland OH USA"},{"name":"Graduate School of Biomedical Engineering University of New South Wales Sydney NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,10,31]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2004.07.014"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S8756-3282(98)00035-0"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10237-007-0087-9"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.5966\/sctm.2011\u20100056"},{"key":"e_1_2_7_6_1","unstructured":"ChangH DochevaD KnotheUR et\u00a0al. 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