{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:50:58Z","timestamp":1788871858270,"version":"build-2803163510"},"reference-count":57,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,7,4]],"date-time":"2014-07-04T00:00:00Z","timestamp":1404432000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000106","name":"Saskatchewan Health Research Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000106","id-type":"DOI","asserted-by":"crossref"}]},{"name":"U.S. DOE"},{"DOI":"10.13039\/100006151","name":"Basic Energy Sciences","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100006151","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100006132","name":"Office of Science","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100006132","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Anatomy"],"published-print":{"date-parts":[[2014,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The most abundant cell in bone, osteocytes form an interconnected system upon which the regulation of healthy bone relies. Although the complete nature of the role of osteocytes has yet to be defined, they are generally accepted to play a part in the sensing of load and the initiation of damage repair. A previous study conducted by our group identified variation of up to 30% in osteocyte lacunar density and morphological parameters between regions of a single cross\u2010section of human femoral shaft; that study, however, was limited to a single individual. The aim of the current study was to determine whether this pattern consistently occurs in healthy young male femora. Anterior, posterior, medial and lateral blocks were prepared from the proximal femoral shaft of seven males and synchrotron radiation micro\u2010CT imaged. Average lacunar densities (\u00b1 SD) from the anterior, posterior, medial and lateral regions were 23\u00a0394\u00a0\u00b1\u00a01705, 30\u00a0180\u00a0\u00b1\u00a04860, 35\u00a0946\u00a0\u00b1\u00a05990 and 29\u00a0678\u00a0\u00b1\u00a06081\u00a0lacunae per mm\n                    <jats:sup>3<\/jats:sup>\n                    of bone tissue, respectively. These values were significantly different between the anterior and both the medial and posterior regions (\n                    <jats:italic>P\u00a0<\/jats:italic>\n                    &lt;\n                    <jats:italic>\u00a0<\/jats:italic>\n                    0.05). The density of the combined anterior and posterior regions was also significantly lower (\n                    <jats:italic>P\u00a0<\/jats:italic>\n                    =\n                    <jats:italic>\u00a0<\/jats:italic>\n                    0.006) than the density of the combined medial and lateral regions. Although no difference was found in predominant orientation, shape differences were found; with the combined anterior\u2010posterior regions having lacunae that were significantly more elongated and less flat than the combined medial\u2010lateral values (\n                    <jats:italic>P\u00a0<\/jats:italic>\n                    &lt;\n                    <jats:italic>\u00a0<\/jats:italic>\n                    0.001). As expected, in this larger study, there was a dramatic difference in lacunar density between the medial and anterior region (up to ~\u00a054%). The study clearly demonstrates that the high variation seen in osteocyte lacunar density as well as other lacunar parameters, noted in a number of biomechanical, age and pathology studies, are well within the range of normal variation; however, the reasons for and consequences of this variation remain unclear. Lacunar parameters including abundance and shape are being increasingly incorporated into computational modeling of bone biology and this paper represents a more comprehensive description of normal healthy lacunae.\n                  <\/jats:p>","DOI":"10.1111\/joa.12213","type":"journal-article","created":{"date-parts":[[2014,7,4]],"date-time":"2014-07-04T08:01:42Z","timestamp":1404460902000},"page":"328-336","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Normal variation in cortical osteocyte lacunar parameters in healthy young males"],"prefix":"10.1111","volume":"225","author":[{"given":"Yasmin","family":"Carter","sequence":"first","affiliation":[{"name":"Department of Anatomy &amp; Cell Biology University of Saskatchewan Saskatoon SK Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica L.","family":"Suchorab","sequence":"additional","affiliation":[{"name":"Department of Anatomy &amp; Cell Biology University of Saskatchewan Saskatoon SK Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. 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