{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T06:08:44Z","timestamp":1791612524338,"version":"4.3.4"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,12,1]],"date-time":"2014-12-01T00:00:00Z","timestamp":1417392000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100008760","name":"National Highway Traffic Safety Administration","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100008760","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Anatomy"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Brain injuries resulting from motor vehicle crashes (MVC) are extremely common yet the details of the mechanism of injury remain to be well characterized. Skull deformation is believed to be a contributing factor to some types of traumatic brain injury (TBI). Understanding biomechanical contributors to skull deformation would provide further insight into the mechanism of head injury resulting from blunt trauma. In particular, skull thickness is thought be a very important factor governing deformation of the skull and its propensity for fracture. Current computed tomography (CT) technology is limited in its ability to accurately measure cortical thickness using standard techniques. A method to evaluate cortical thickness using cortical density measured from CT data has been developed previously. This effort validates this technique for measurement of skull table thickness in clinical head CT scans using two postmortem human specimens. Bone samples were harvested from the skulls of two cadavers and scanned with microCT to evaluate the accuracy of the estimated cortical thickness measured from clinical CT. Clinical scans were collected at 0.488 and 0.625\u00a0mm in plane resolution with 0.625\u00a0mm thickness. The overall cortical thickness error was determined to be 0.078\u00a0\u00b1\u00a00.58\u00a0mm for cortical samples thinner than 4\u00a0mm. It was determined that 91.3% of these differences fell within the scanner resolution. Color maps of clinical CT thickness estimations are comparable to color maps of microCT thickness measurements, indicating good quantitative agreement. These data confirm that the cortical density algorithm successfully estimates skull table thickness from clinical CT scans. The application of this technique to clinical CT scans enables evaluation of cortical thickness in population\u2010based studies.<\/jats:p>","DOI":"10.1111\/joa.12259","type":"journal-article","created":{"date-parts":[[2014,12,1]],"date-time":"2014-12-01T15:54:50Z","timestamp":1417449290000},"page":"73-80","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":59,"title":["Estimation of skull table thickness with clinical CT and validation with microCT"],"prefix":"10.1111","volume":"226","author":[{"given":"Elizabeth M.","family":"Lillie","sequence":"first","affiliation":[{"name":"Virginia Tech\u2010Wake Forest University Center for Injury Biomechanics Winston\u2010Salem NC USA"},{"name":"Wake Forest University School of Medicine Winston\u2010Salem NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jillian E.","family":"Urban","sequence":"additional","affiliation":[{"name":"Virginia Tech\u2010Wake Forest University Center for Injury Biomechanics Winston\u2010Salem NC USA"},{"name":"Wake Forest University School of Medicine Winston\u2010Salem NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4383-0106","authenticated-orcid":false,"given":"Ashley A.","family":"Weaver","sequence":"additional","affiliation":[{"name":"Virginia Tech\u2010Wake Forest University Center for Injury Biomechanics Winston\u2010Salem NC USA"},{"name":"Wake Forest University School of Medicine Winston\u2010Salem NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander K.","family":"Powers","sequence":"additional","affiliation":[{"name":"Wake Forest University School of Medicine Winston\u2010Salem NC USA"},{"name":"Department of Neurosurgery Wake Forest University Winston\u2010Salem NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel D.","family":"Stitzel","sequence":"additional","affiliation":[{"name":"Virginia Tech\u2010Wake Forest University Center for Injury Biomechanics Winston\u2010Salem NC USA"},{"name":"Wake Forest University School of Medicine Winston\u2010Salem NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,12]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"1","article-title":"Surveillance for traumatic brain injury\u2010related deaths\u00a0\u2013\u00a0United States, 1997\u20132007","volume":"60","author":"Coronado V","year":"2011","journal-title":"MMWR Surveill Summ"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1118\/1.598629"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.15620\/cdc.5571"},{"key":"e_1_2_7_5_1","first-page":"341","article-title":"Fracture behavior of the skull frontal bone against cylindrical surfaces","volume":"14","author":"Hodgson V","year":"1970","journal-title":"Stapp car crash journal"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9290(71)90031-5"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9290(71)90039-X"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9290(90)90059-C"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.3949\/ccjm.76a.08041"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9290(70)90059-X"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/BFb0067700"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1103\/PhysRevLett.103.108702"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1088\/0031-9155\/43\/3\/013"},{"key":"e_1_2_7_14_1","doi-asserted-by":"crossref","unstructured":"NusholtzGS LuxP KaikerP et\u00a0al. 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