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However, the age range in which enucleation is associated with risk of orbital maldevelopment and the extent of asymmetry remains controversial. In this study, patients who had undergone unilateral enucleation at different ages without orbital implantation were analysed to investigate bony orbital development after enucleation. A total of 87 Chinese adult patients were included. Their bony orbital volume and orbital aditus area were measured using three\u2010dimensional reconstructive models based on patients' computer tomography scans. The ratio of the parameter values of the affected orbit to the unaffected orbit was calculated and described as the orbital symmetry index. The results showed that the bony orbit grew until approximately 18\u2005years old. Enucleation after that age did not affect the orbit, whereas enucleation before that age led to significant orbital maldevelopment. The relative reduction ranged up to 20% in orbital volume and 17% in the orbital aditus area. The extent of orbital maldevelopment was correlated to the age of\u00a0enucleation. The symmetry index of orbital volume\u00a0=\u00a0\u22120.0003<jats:italic>x<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0+\u00a00.0159<jats:italic>x\u00a0<\/jats:italic>+\u00a00.8112 (<jats:italic>x<\/jats:italic>\u00a0=\u00a0the age of enucleation). The symmetry index of the orbital aditus area\u00a0=\u00a0\u22120.0002<jats:italic>x<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0+\u00a00.0119<jats:italic>x<\/jats:italic>\u00a0+\u00a00.8504 (<jats:italic>x<\/jats:italic>\u00a0=\u00a0the age of\u00a0enucleation). The regression formulae were used to predict the severity of orbital asymmetry after unilateral enucleation, and evaluate the necessity and efficacy of interventions following enucleation.<\/jats:p>","DOI":"10.1111\/joa.12372","type":"journal-article","created":{"date-parts":[[2015,9,22]],"date-time":"2015-09-22T12:03:58Z","timestamp":1442923438000},"page":"647-653","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Bony orbital maldevelopment after enucleation"],"prefix":"10.1111","volume":"227","author":[{"given":"Yongrong","family":"Ji","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Shanghai Ninth People's Hospital Shanghai Jiaotong University School of Medicine Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fuxiang","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Shanghai Ninth People's Hospital Shanghai Jiaotong University School of Medicine Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huifang","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Shanghai Ninth People's Hospital Shanghai Jiaotong University School of Medicine Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qing","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Shanghai Ninth People's Hospital Shanghai Jiaotong University School of Medicine Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shengfang","family":"Ge","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Shanghai Ninth People's Hospital Shanghai Jiaotong University School of Medicine Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xianqun","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Shanghai Ninth People's Hospital Shanghai Jiaotong University School of Medicine Shanghai 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