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Here, we first compared layer thickness of the olfactory bulb between wild\u2010type (WT<\/jats:styled-content>) and CRMP<\/jats:styled-content>4<\/jats:italic>\u2010knockout (KO<\/jats:styled-content>) mice. The mitral cell layer (MCL<\/jats:styled-content>) was significantly thinner, whereas the external plexiform layer (EPL<\/jats:styled-content>) was significantly thicker in CRMP<\/jats:styled-content>4<\/jats:italic>\u2010KO<\/jats:styled-content> mice at postnatal day 0 (PD<\/jats:styled-content>0) compared with WT<\/jats:styled-content>s. However, differences in layer thickness disappeared by PD<\/jats:styled-content>14. No apoptotic cells were found in the MCL<\/jats:styled-content>, and the number of mitral cells (MC<\/jats:styled-content>s) identified with a specific marker (i.e. Tbx21 antibody) did not change in CRMP<\/jats:styled-content>4<\/jats:italic>\u2010KO<\/jats:styled-content> neonates. However, DiI\u2010tracing showed that the length of mitral cell apical dendrites was greater in CRMP<\/jats:styled-content>4<\/jats:italic>\u2010KO<\/jats:styled-content> neonates than in WT<\/jats:styled-content>s. In addition, expression of CRMP<\/jats:styled-content>4 mRNA<\/jats:styled-content> in WT<\/jats:styled-content> mice was most abundant in the MCL<\/jats:styled-content> at PD<\/jats:styled-content>0 and decreased afterward. These results suggest that CRMP<\/jats:styled-content>4 contributes to dendritic elongation. Our in\u00a0vitro<\/jats:italic> studies showed that deletion or knockdown of CRMP<\/jats:styled-content>4<\/jats:italic> resulted in enhanced growth of MAP<\/jats:styled-content>2\u2010positive neurites, whereas overexpression of CRMP<\/jats:styled-content>4<\/jats:italic> reduced their growth, suggesting a new role for CRMP<\/jats:styled-content>4 as a suppressor of dendritic elongation. Overall, our data suggest that disruption of CRMP<\/jats:styled-content>4 produces a temporary alteration in EPL<\/jats:styled-content> thickness, which is constituted mainly of mitral cell apical dendrites, through the enhanced growth of these dendrites.<\/jats:p>","DOI":"10.1111\/joa.12434","type":"journal-article","created":{"date-parts":[[2016,1,7]],"date-time":"2016-01-07T12:19:34Z","timestamp":1452169174000},"page":"792-804","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Deletion of collapsin response mediator protein 4 results in abnormal layer thickness and elongation of mitral cell apical dendrites in the neonatal olfactory bulb"],"prefix":"10.1111","volume":"228","author":[{"given":"Atsuhiro","family":"Tsutiya","sequence":"first","affiliation":[{"name":"Graduate School of Life Sciences Toyo University Oura Gunma 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