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Weight\u2010bearing limb bones in these species have geometries that enable them to withstand deformations due to loading, both within and between species. Departures from the expected scaling of bone size and shape to body mass occur in mammals that have become specialized for different types of locomotion. For example, mammals adapted for frequent running and jumping behaviors have hind limb bones that are long in relation to body mass, but with narrower cross\u2010sections than predicted for their length. The Longshanks mouse was recently established, a selectively bred line of mice with ~12\u201313% longer tibiae relative to body mass. This increased limb length resembles superficially the derived limb proportions of rodents adapted for hopping and jumping. Here, 3D geometric morphometrics and analyses of bone cross\u2010sectional geometry were combined to determine whether selection for increased relative tibia length in Longshanks mice has altered the scaling relationship of size and shape, and\/or bone robusticity, relative to the tibiae of random\u2010bred control mice from the same genetic background. The results suggest that the Longshanks tibia is not a geometrically scaled version of the control tibiae. Instead, the Longshanks tibia has become narrower in cross\u2010section in relation to its increased length, leading to a decrease in overall bending strength when compared with control tibiae. These changes in bone shape and robusticity resemble the derived morphology of mammals adapted for running and jumping, with important implications for the material properties and strength of bone in these mammals.<\/jats:p>","DOI":"10.1111\/joa.12459","type":"journal-article","created":{"date-parts":[[2016,3,22]],"date-time":"2016-03-22T12:38:30Z","timestamp":1458650310000},"page":"940-951","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Changes in shape and cross\u2010sectional geometry in the tibia of mice selectively bred for increases in relative bone length"],"prefix":"10.1111","volume":"228","author":[{"given":"Miranda N.","family":"Cosman","sequence":"first","affiliation":[{"name":"Faculty of Veterinary Medicine Department of Comparative Biology and Experimental Medicine University of Calgary Calgary AB Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leah 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