{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T10:15:17Z","timestamp":1789726517495,"version":"4.0.1"},"reference-count":42,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,5,12]],"date-time":"2016-05-12T00:00:00Z","timestamp":1463011200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001824","name":"Grantov\u00e1 Agentura \u010cesk\u00e9 Republiky","doi-asserted-by":"publisher","award":["14\u201037368G"],"award-info":[{"award-number":["14\u201037368G"]}],"id":[{"id":"10.13039\/501100001824","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001824","name":"Grantov\u00e1 Agentura \u010cesk\u00e9 Republiky","doi-asserted-by":"publisher","award":["14\u201029273P"],"award-info":[{"award-number":["14\u201029273P"]}],"id":[{"id":"10.13039\/501100001824","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004755","name":"Veterin\u00e1rn\u00ed a Farmaceutick\u00e1 Univerzita Brno","doi-asserted-by":"publisher","award":["61\/2013\/FVL"],"award-info":[{"award-number":["61\/2013\/FVL"]}],"id":[{"id":"10.13039\/501100004755","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Anatomy"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Chameleon teeth develop as individual structures at a distance from the developing jaw bone during the pre\u2010hatching period and also partially during the post\u2010hatching period. However, in the adult, all teeth are fused together and tightly attached to the jaw bone by mineralized attachment tissue to form one functional unit. Tooth to bone as well as tooth to tooth attachments are so firm that if injury to the oral cavity occurs, several neighbouring teeth and pieces of jaw can be broken off. We analysed age\u2010related changes in chameleon acrodont dentition, where ankylosis represents a physiological condition, whereas in mammals, ankylosis only occurs in a pathological context. The changes in hard\u2010tissue morphology and mineral composition leading to this fusion were analysed. For this purpose, the lower jaws of chameleons were investigated using X\u2010ray micro\u2010computed tomography, laser\u2010induced breakdown spectroscopy and microprobe analysis. For a long time, the dental pulp cavity remained connected with neighbouring teeth and also to the underlying bone marrow cavity. Then, a progressive filling of the dental pulp cavity by a mineralized matrix occurred, and a complex network of non\u2010mineralized channels remained. The size of these unmineralized channels progressively decreased until they completely disappeared, and the dental pulp cavity was filled by a mineralized matrix over time. Moreover, the distribution of calcium, phosphorus and magnesium showed distinct patterns in the different regions of the tooth\u2013bone interface, with a significant progression of mineralization in dentin as well as in the supporting bone. In conclusion, tooth\u2013bone fusion in chameleons results from an enhanced production of mineralized tissue during post\u2010hatching development. Uncovering the developmental processes underlying these outcomes and performing comparative studies is necessary to better understand physiological ankylosis; for that purpose, the chameleon can serve as a useful model species.<\/jats:p>","DOI":"10.1111\/joa.12490","type":"journal-article","created":{"date-parts":[[2016,5,13]],"date-time":"2016-05-13T02:32:42Z","timestamp":1463106762000},"page":"356-368","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Age\u2010related changes in the tooth\u2013bone interface area\u00a0of acrodont dentition in the chameleon"],"prefix":"10.1111","volume":"229","author":[{"given":"Hana","family":"Dosed\u011blov\u00e1","sequence":"first","affiliation":[{"name":"Department of Anatomy Histology and Embryology University of Veterinary and Pharmaceutical Sciences Brno Brno Czech Republic"},{"name":"Institute of Animal Physiology and Genetics, v.v.i. Academy of Sciences of the Czech Republic Brno Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kate\u0159ina","family":"\u0160t\u011bp\u00e1nkov\u00e1","sequence":"additional","affiliation":[{"name":"Department of Chemistry Faculty of Science Masaryk University Brno Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom\u00e1\u0161","family":"Zikmund","sequence":"additional","affiliation":[{"name":"CEITEC \u2013 Central European Institute of Technology Brno University of Technology Brno  Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herve","family":"Lesot","sequence":"additional","affiliation":[{"name":"INSERM (French National Institute of Health and Medical Research), \u2018Osteoarticular and Dental Regenerative NanoMedicine\u2019 Laboratory Facult\u00e9 de M\u00e9dicine Universit\u00e9 de Strasbourg UMR 1109 Strasbourg France"},{"name":"Facult\u00e9 de Chirurgie Dentaire Universit\u00e9 de Strasbourg Strasbourg France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jozef","family":"Kaiser","sequence":"additional","affiliation":[{"name":"CEITEC \u2013 Central European Institute of Technology Brno University of Technology Brno  Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karel","family":"Novotn\u00fd","sequence":"additional","affiliation":[{"name":"Department of Chemistry Faculty of Science Masaryk University Brno Czech Republic"},{"name":"CEITEC \u2013 Central European Institute of Technology Brno University of Technology Brno  Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"\u0160temb\u00edrek","sequence":"additional","affiliation":[{"name":"Institute of Animal Physiology and Genetics, v.v.i. Academy of Sciences of the Czech Republic Brno Czech Republic"},{"name":"Department of Oral and Maxillofacial Surgery University Hospital Ostrava Ostrava Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zden\u011bk","family":"Knotek","sequence":"additional","affiliation":[{"name":"Clinic of Small Animals University of Veterinary and Pharmaceutical Sciences Brno Brno Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Old\u0159ich","family":"Zahradn\u00ed\u010dek","sequence":"additional","affiliation":[{"name":"Department of Teratology Institute of Experimental Medicine Academy of Sciences of the Czech Republic Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0262-6774","authenticated-orcid":false,"given":"Marcela","family":"Buchtov\u00e1","sequence":"additional","affiliation":[{"name":"Institute of Animal Physiology and Genetics, v.v.i. Academy of Sciences of the Czech Republic Brno Czech Republic"},{"name":"Department of Experimental Biology Masaryk University Brno Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,5,12]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sab.2007.10.033"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00223-005-0134-4"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034513510321"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00496668"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0910778107"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1747-4477.1999.tb00088.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00298503"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345920710111201"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aanat.2006.09.008"},{"key":"e_1_2_7_11_1","first-page":"313","article-title":"Functional anatomy of chameleon tongue","volume":"119","author":"Bell DA","year":"1989","journal-title":"Zool Jb Anat"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00296775"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2012.10.019"},{"key":"e_1_2_7_14_1","first-page":"1","article-title":"Comparative ecology and behaviour of Chamaeleo pumilis pumilis (Gemelin) and C. namaguensis A. Smith (Sauria: Chamaeleonidae)","volume":"61","author":"Burrage BR","year":"1973","journal-title":"Ann S Aft Mus"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1039\/b708985f"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1180\/minmag.2008.072.1.247"},{"key":"e_1_2_7_17_1","first-page":"117","volume-title":"Biology of the Reptile","author":"Edmund AG","year":"1969"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsb.2013.09.018"},{"key":"e_1_2_7_19_1","first-page":"173","volume-title":"Mechanisms and Phylogeny of Mineralization in Biological Systems","author":"Gaengler P","year":"1991"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.1992.tb01671.x"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00216-010-3976-1"},{"key":"e_1_2_7_22_1","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1111\/j.1096-3642.1930.tb00988.x","article-title":"The anatomy and mechanism of the tongue of Chamaeleon calcaratus","volume":"1930","author":"Gnanamuthu CP","year":"1930","journal-title":"Proc Zool Soc Lond"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.zool.2014.01.001"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1159\/000242396"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0584-8547(01)00187-2"},{"key":"e_1_2_7_26_1","first-page":"154","volume-title":"Teeth, Form, Function, Evolution","author":"Lucas PW","year":"1979"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/jemt.10222"},{"key":"e_1_2_7_28_1","first-page":"850","article-title":"On the myology of Chamaelon parsonii","volume":"1870","author":"Mivart SG","year":"1870","journal-title":"Proc Zool Soc Lond"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1177\/154405910408300311"},{"key":"e_1_2_7_30_1","first-page":"549","article-title":"From reptile to mammals: evolutionary considerations of dentition with emphasis on tooth attachment","volume":"52","author":"Osborn JW","year":"1984","journal-title":"Symp Zool Soc Lond"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.5962\/bhl.part.82383"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.1997.tb00096.x"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1177\/10454411010120050501"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7998.1992.tb06126.x"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0757.2000.2240106.x"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345910700030601"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1098\/rsbl.2005.0299"},{"key":"e_1_2_7_38_1","volume-title":"Development of The Tooth and its Supporting Tissue","author":"Ten Cate AR","year":"1994"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345950740110901"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.1997.12.3.380"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345740530020601"},{"key":"e_1_2_7_42_1","first-page":"1","article-title":"Tooth implantation and replacement in squamates, with special reference to mosasaurs lizards and snakes","volume":"3271","author":"Zaher H","year":"1999","journal-title":"Am Mus Novit"},{"key":"e_1_2_7_43_1","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1242\/jeb.10.2.174","article-title":"The mechanism of projection of the chameleon's tongue","volume":"10","author":"Zoond A","year":"1933","journal-title":"J Exp Biol"}],"container-title":["Journal of Anatomy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjoa.12490","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjoa.12490","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/joa.12490","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T03:17:34Z","timestamp":1696216654000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/joa.12490"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5,12]]},"references-count":42,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016,9]]}},"alternative-id":["10.1111\/joa.12490"],"URL":"https:\/\/doi.org\/10.1111\/joa.12490","archive":["Portico"],"relation":{},"ISSN":["0021-8782","1469-7580"],"issn-type":[{"value":"0021-8782","type":"print"},{"value":"1469-7580","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,5,12]]},"assertion":[{"value":"2016-04-06","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-05-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}