{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T04:33:06Z","timestamp":1790829186069,"version":"4.1.0"},"reference-count":40,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000268","name":"Biotechnology and Biological Sciences Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000268","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["G0700095"],"award-info":[{"award-number":["G0700095"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01GM076692"],"award-info":[{"award-number":["R01GM076692"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Anatomy"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Segmentation of the vertebrate body axis is established in the embryo by formation of somites, which give rise to the axial muscles (myotome) and vertebrae (sclerotome). To allow a muscle to attach to two successive vertebrae, the myotome and sclerotome must be repositioned by half a segment with respect to each other. Two main models have been put forward: \u2018resegmentation\u2019 proposes that each half\u2010sclerotome joins with the half\u2010sclerotome from the next adjacent somite to form a vertebra containing cells from two successive somites on each side of the midline. The second model postulates that a single vertebra is made from a single somite and that the sclerotome shifts with respect to the myotome. There is conflicting evidence for these models, and the possibility that the mechanism may vary along the vertebral column has not been considered. Here we use DiI and DiO to trace somite contributions to the vertebrae in different axial regions in the chick embryo. We demonstrate that vertebral bodies and neural arches form by resegmentation but that sclerotome cells shift in a region\u2010specific manner according to their dorsoventral position within a segment. We propose a \u2018resegmentation\u2010shift\u2019 model as the mechanism for amniote vertebral patterning.<\/jats:p>","DOI":"10.1111\/joa.12540","type":"journal-article","created":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T11:21:44Z","timestamp":1472728904000},"page":"290-296","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["A resegmentation\u2010shift model for vertebral patterning"],"prefix":"10.1111","volume":"230","author":[{"given":"Lizzy","family":"Ward","sequence":"first","affiliation":[{"name":"Department of Cell and Developmental Biology University College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan E.","family":"Evans","sequence":"additional","affiliation":[{"name":"Department of Cell and Developmental Biology University College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio D.","family":"Stern","sequence":"additional","affiliation":[{"name":"Department of Cell and Developmental Biology University College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,9]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1242\/dev.104.1.15","article-title":"Determination of somite cells: independence of cell differentiation and morphogenesis","volume":"104","author":"Aoyama H","year":"1988","journal-title":"Development"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0925-4773(00)00481-0"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00305126"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00188544"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.103.1.69"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1159\/000143255"},{"key":"e_1_2_5_8_1","first-page":"15","article-title":"The behaviour of embryonic chick and quail tissues in culture","volume":"61","author":"Bellairs R","year":"1981","journal-title":"J Embryol Exp Morphol"},{"key":"e_1_2_5_9_1","first-page":"99","article-title":"Brachial muscles in the chick embryo: the fate of individual somites","volume":"77","author":"Beresford B","year":"1983","journal-title":"J. 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Beobachtungen an S\u00e4ugetierembryonen","volume":"1886","author":"Froriep A","year":"1886","journal-title":"Arch Anat Physiol"},{"key":"e_1_2_5_19_1","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1242\/dev.116.2.441","article-title":"Determination of epithelial half\u2010somites in skeletal morphogenesis","volume":"116","author":"Goldstein RS","year":"1992","journal-title":"Development"},{"key":"e_1_2_5_20_1","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1002\/aja.1001950404","article-title":"A series of normal stages in the development of the chick embryo","volume":"195","author":"Hamburger V","year":"1951","journal-title":"Dev Dyn"},{"key":"e_1_2_5_21_1","first-page":"137","article-title":"\u00dcber das Schicksal des Proatlas und \u00dcber die Entwicklung der Kopfgelenke bei Reptilien und V\u00f6geln","volume":"53","author":"Hayek H","year":"1924","journal-title":"Morph Jahrb"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1159\/000147811"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004290000110"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004290000131"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.5962\/bhl.title.51251"},{"key":"e_1_2_5_26_1","doi-asserted-by":"crossref","DOI":"10.5962\/bhl.title.6098","volume-title":"The Development of the Chick \u2013 an Introduction to Embryology","author":"Lillie FR","year":"1936"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420220306"},{"key":"e_1_2_5_28_1","volume-title":"Untersuchungen \u00fcber die Entwicklung der Wirbelthiere","author":"Remak R","year":"1855"},{"key":"e_1_2_5_29_1","first-page":"339","volume-title":"Handbuch der Vergleichenden und Experimentellen Entwicklungslehre der Wirbelthiere","author":"Schauinsland H","year":"1905"},{"key":"e_1_2_5_30_1","first-page":"23","article-title":"The early development of the human vertebral column","volume":"33","author":"Sensenig EC","year":"1949","journal-title":"Contrib Embryol"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7580.2012.01497.x"},{"key":"e_1_2_5_32_1","first-page":"109","article-title":"Two distinct mechanisms for segmentation?","volume":"1","author":"Stern CD","year":"1990","journal-title":"Semin Dev Biol"},{"key":"e_1_2_5_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0070-2153(08)60505-0"},{"key":"e_1_2_5_34_1","doi-asserted-by":"crossref","DOI":"10.1093\/oso\/9780199634231.001.0001","volume-title":"Essential Developmental Biology: A Practical Approach","author":"Stern CD","year":"1993"},{"key":"e_1_2_5_35_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.99.2.261"},{"key":"e_1_2_5_36_1","first-page":"209","article-title":"Interactions between neurites and somite cells: inhibition and stimulation of nerve growth in the chick embryo","volume":"91","author":"Stern CD","year":"1986","journal-title":"J. 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