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Both the preplacode region and neural crest (<jats:styled-content style=\"fixed-case\">NC<\/jats:styled-content>) derive from subdivision of the neural border region, and further individualization of the placode domain is established by a reciprocal interaction between placodal precursors and <jats:styled-content style=\"fixed-case\">NC<\/jats:styled-content> cells (<jats:styled-content style=\"fixed-case\">NCC<\/jats:styled-content>s). It has long been known that <jats:styled-content style=\"fixed-case\">NCC<\/jats:styled-content>s are present in the adenohypophysis as interstitial cells. A recent report demonstrated that <jats:styled-content style=\"fixed-case\">NCC<\/jats:styled-content>s also contribute to the formation of pericytes in the developing pituitary. Here, we attempt to further clarify the role of <jats:styled-content style=\"fixed-case\">NCC<\/jats:styled-content>s in pituitary development using <jats:italic>P0\u2010Cre\/<jats:styled-content style=\"fixed-case\">EGFP<\/jats:styled-content><\/jats:italic> reporter mice. Spatiotemporal analyses revealed that <jats:styled-content style=\"fixed-case\">GFP<\/jats:styled-content>\u2010positive <jats:styled-content style=\"fixed-case\">NCC<\/jats:styled-content>s invaded the adenohypophysis in a stepwise manner. The first wave was detected on mouse embryonic day 9.5 (E9.5), when the pituitary primordium begins to be formed by adenohypophyseal placode cells; the second wave occurred on E14.5, when vasculogenesis proceeds from Atwell's recess. Finally, fate tracing of <jats:styled-content style=\"fixed-case\">NCC<\/jats:styled-content>s demonstrated that <jats:styled-content style=\"fixed-case\">NC<\/jats:styled-content>\u2010derived cells in the adenohypophysis terminally differentiate into all hormone\u2010producing cell lineages as well as pericytes. Our data suggest that <jats:styled-content style=\"fixed-case\">NCC<\/jats:styled-content>s contribute to pituitary organogenesis and vasculogenesis in conjunction with placode\u2010derived pituitary stem\/progenitor cells.<\/jats:p>","DOI":"10.1111\/joa.12572","type":"journal-article","created":{"date-parts":[[2016,12,27]],"date-time":"2016-12-27T13:43:50Z","timestamp":1482846230000},"page":"373-380","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Gene tracing analysis reveals the contribution of neural crest\u2010derived cells in pituitary development"],"prefix":"10.1111","volume":"230","author":[{"given":"Hiroki","family":"Ueharu","sequence":"first","affiliation":[{"name":"Division of Life Science Graduate School of Agriculture Meiji University Kawasaki Kanagawa 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