{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T19:43:47Z","timestamp":1770839027781,"version":"3.50.1"},"reference-count":32,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,2,28]],"date-time":"2017-02-28T00:00:00Z","timestamp":1488240000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Anatomy"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Craniofacial development relies on coordinated tissue interactions that allow for patterning and growth of the face. We know <jats:italic>a priori<\/jats:italic> that the Wingless, fibroblast growth factor, Hedgehog and transforming growth factor\u2010beta growth factor signaling pathways are required for the development of the face, but how they contribute to the shape of the face is largely untested. Here, we test how each signaling pathway contributes to the overall morphology of the zebrafish anterior neurocranium. We tested the contribution of each signaling pathway to the development of the ethmoid plate during three distinct time periods: the time of neural crest migration [10 hour post fertilization (hpf)]; once the neural crest is resident in the face (20 hpf); and finally at the time at which the cartilaginous condensations are being initiated (48 hpf). Using geometric morphometric analysis, we conclude that each signaling pathway contributes to the shape, size and morphology of the ethmoid plate in a dose\u2010, and time\u2010dependent fashion.<\/jats:p>","DOI":"10.1111\/joa.12592","type":"journal-article","created":{"date-parts":[[2017,2,28]],"date-time":"2017-02-28T12:19:50Z","timestamp":1488284390000},"page":"701-709","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Growth factor signaling alters the morphology of the zebrafish ethmoid plate"],"prefix":"10.1111","volume":"230","author":[{"given":"Brian J.","family":"Cusack","sequence":"first","affiliation":[{"name":"Department of Oral Biology Center for Craniofacial Regeneration University of Pittsburgh Pittsburgh PA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Trish E.","family":"Parsons","sequence":"additional","affiliation":[{"name":"Department of Oral Biology School of Dental 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