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During this period, 612 previously known chicken mi\n                    <jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>\n                    s (gga\u2010mi\n                    <jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>\n                    s) and 401 non\u2010identified sequences were expressed in the interdigital mesoderm. Thirty\u2010six micro\n                    <jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>\n                    s, represented by more than 750 reads per million, displayed differential expression between stages\n                    <jats:styled-content style=\"fixed-case\">HH<\/jats:styled-content>\n                    29 (6 id) and\n                    <jats:styled-content style=\"fixed-case\">HH<\/jats:styled-content>\n                    32 (7.5 id), which correspond to the onset and the peak of interdigital cell death. Twenty mi\n                    <jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>\n                    s were upregulated by at least 1.5\u2010fold, and sixteen were downregulated by at least 0.5\u2010fold. Upregulated mi\n                    <jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>\n                    s included mi\n                    <jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>\n                    s with recognized proapoptotic functions in other systems (miR\u2010181 family, miR\u2010451 and miR\u2010148a), mi\n                    <jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>\n                    s associated with inflammation and cell senescence (miR\u201021 and miR\u2010146) and mi\n                    <jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>\n                    s able to induce changes in the extracellular matrix (miR\u201030c). In contrast, mi\n                    <jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>\n                    s with known antiapoptotic effects in other systems, such as miR\u2010222 and miR\u2010205, became downregulated. In addition, miR\u201092, an important positive regulator of cell proliferation, was also downregulated. Together, these findings indicate a role for mi\n                    <jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>\n                    s in the control of tissue regression and cell death in a characteristic morphogenetic embryonic process based on massive apoptosis.\n                  <\/jats:p>","DOI":"10.1111\/joa.12629","type":"journal-article","created":{"date-parts":[[2017,5,25]],"date-time":"2017-05-25T12:14:06Z","timestamp":1495714446000},"page":"275-286","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Interdigital tissue remodelling in the embryonic limb involves dynamic regulation of the mi\n                    <scp>RNA<\/scp>\n                    profiles"],"prefix":"10.1111","volume":"231","author":[{"given":"Beatriz","family":"Garcia\u2010Riart","sequence":"first","affiliation":[{"name":"Departamento de Anatom\u00eda y Biolog\u00eda Celular and IDIVAL Universidad de Cantabria 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