{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T11:36:11Z","timestamp":1790422571852,"version":"4.1.0"},"reference-count":36,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,7,3]],"date-time":"2017-07-03T00:00:00Z","timestamp":1499040000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"ARC Discovery Grant"},{"name":"Macintosh Memorial Fund of the Department of Anatomy and Histology"},{"name":"Murphy Laboratory"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Anatomy"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The uterine luminal epithelium is the first site of contact between fetal and maternal tissues during therian pregnancy and must undergo specialised changes for implantation of the blastocyst to be successful. These changes, collectively termed the plasma membrane transformation (<jats:styled-content style=\"fixed-case\">PMT<\/jats:styled-content>), allow the blastocyst to attach to the uterine epithelium preceding the formation of a placenta. There are similarities in the morphological and molecular changes occurring in live\u2010bearing eutherian species during the <jats:styled-content style=\"fixed-case\">PMT<\/jats:styled-content> studied so far. Similar cellular remodelling occurs in a marsupial species, the fat\u2010tailed dunnart (<jats:italic>Sminthopsis crassicaudata<\/jats:italic>), despite the divergence of marsupials from eutherian mammals over 130 mya, which resulted in the evolution of distinct reproductive strategies. Adhesion molecules along the lateral plasma membrane of uterine epithelium provide a barrier to invasion by the embryo. We thus characterised the presence and change in distribution of epithelial cadherin (E\u2010cadherin) in uterine epithelium from non\u2010pregnant fat\u2010tailed dunnarts and compared it to dunnarts in early\u2010, mid\u2010 and late\u2010stage pregnancy. E\u2010cadherin staining is localised to the lateral plasma membrane in uterine epithelium from non\u2010pregnant and early\u2010stage pregnant dunnarts. The E\u2010cadherin staining is cytoplasmic in epithelium from uteri of mid\u2010 and late\u2010stage pregnant dunnarts. This loss of localised staining suggests that the adherens junction dissociates from the lateral plasma membrane, allowing for invasion between the epithelial cells by the blastocyst. As the changes during pregnancy to cadherin were similar in the laboratory rat with highly invasive (haemochorial) placentation, a live\u2010bearing lizard species with non\u2010invasive (epitheliochorial) placentation and a marsupial, the fat\u2010tailed dunnart, which has invasive (endotheliochorial) placentation, we suggest that the molecular mechanisms allowing for successful pregnancy are conserved among mammals during the early stages of pregnancy regardless of placental invasiveness.<\/jats:p>","DOI":"10.1111\/joa.12648","type":"journal-article","created":{"date-parts":[[2017,7,3]],"date-time":"2017-07-03T07:59:31Z","timestamp":1499068771000},"page":"359-365","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Epithelial cadherin disassociates from the lateral plasma membrane of uterine epithelial cells throughout pregnancy in a 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