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The whole process is coordinated through a complex series of biological, chemical and perhaps mechanical signals between various elements of the craniofacial system. The aim of this study was to investigate to what extent a computational model can accurately predict the calvarial growth in wild\u2010type (<jats:styled-content style=\"fixed-case\">WT<\/jats:styled-content>) and mutant type (<jats:styled-content style=\"fixed-case\">MT<\/jats:styled-content>) <jats:italic>Fgfr2<\/jats:italic><jats:sup><jats:italic>C342Y\/+<\/jats:italic><\/jats:sup> mice displaying bicoronal suture fusion. A series of morphological studies were carried out to quantify the calvarial growth at P3, P10 and P20 in both mouse types. MicroCT images of a P3 specimen were used to develop a finite element model of skull growth to predict the calvarial shape of <jats:styled-content style=\"fixed-case\">WT<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">MT<\/jats:styled-content> mice at P10. Sensitivity tests were performed and the results compared with <jats:italic>ex\u00a0vivo<\/jats:italic> P10 data. Although the models were sensitive to the choice of input parameters, they predicted the overall skull growth in the <jats:styled-content style=\"fixed-case\">WT<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">MT<\/jats:styled-content> mice. The models also captured the difference between the <jats:italic>ex\u00a0vivo<\/jats:italic><jats:styled-content style=\"fixed-case\">WT<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">MT<\/jats:styled-content> mice. This modelling approach has the potential to be translated to human skull growth and to enhance our understanding of the different reconstruction methods used to manage clinically the different forms of craniosynostosis, and in the long term possibly reduce the number of re\u2010operations in children displaying this condition and thereby enhance their quality of life.<\/jats:p>","DOI":"10.1111\/joa.12764","type":"journal-article","created":{"date-parts":[[2017,12,16]],"date-time":"2017-12-16T10:43:21Z","timestamp":1513421001000},"page":"440-448","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Predicting calvarial growth in normal and craniosynostotic mice using a computational approach"],"prefix":"10.1111","volume":"232","author":[{"given":"Arsalan","family":"Marghoub","sequence":"first","affiliation":[{"name":"Department of Mechanical Engineering University College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Libby","sequence":"additional","affiliation":[{"name":"Medical and Biological Engineering School of Engineering and Computer Science University of Hull Hull UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Babbs","sequence":"additional","affiliation":[{"name":"MRC Molecular Haematology Unit MRC Weatherall Institute of Molecular Medicine University of Oxford Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erwin","family":"Pauws","sequence":"additional","affiliation":[{"name":"Institute of Child Health Great Ormond Street University College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Fagan","sequence":"additional","affiliation":[{"name":"Medical and Biological Engineering School of Engineering and Computer Science University of Hull Hull UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9951-2975","authenticated-orcid":false,"given":"Mehran","family":"Moazen","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering University College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,12,15]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2009.05.070"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsbiomaterials.6b00557"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1039\/C6SM00582A"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.32208"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2010.07.043"},{"key":"e_1_2_8_7_1","doi-asserted-by":"crossref","unstructured":"ClaessensM SaurenF WismansJ(1997)Modeling of the human head under impact conditions: a parametric study. 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