{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:02:34Z","timestamp":1787068954697,"version":"build-2736575974"},"reference-count":37,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,5,31]],"date-time":"2018-05-31T00:00:00Z","timestamp":1527724800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004826","name":"Natural Science Foundation of Beijing Municipality","doi-asserted-by":"publisher","award":["7172111"],"award-info":[{"award-number":["7172111"]}],"id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81671005"],"award-info":[{"award-number":["81671005"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81470756"],"award-info":[{"award-number":["81470756"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Anatomy"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Tight junction (\n                    <jats:styled-content style=\"fixed-case\">TJ<\/jats:styled-content>\n                    ) proteins play a dynamic role in paracellular fluid transport in salivary gland epithelia. Most\n                    <jats:styled-content style=\"fixed-case\">TJ<\/jats:styled-content>\n                    studies are carried out in mice and rats. However, the morphology of rodent salivary glands differs from that of human glands. This study aimed to compare the histological features and the expression pattern of\n                    <jats:styled-content style=\"fixed-case\">TJ<\/jats:styled-content>\n                    proteins in porcine salivary glands with those of human and mouse. The results showed that porcine parotid glands were pure serous glands. Submandibular glands (\n                    <jats:styled-content style=\"fixed-case\">SMG<\/jats:styled-content>\n                    s) were serous acinar cell\u2010predominated mixed glands, whereas sublingual glands were mucous acinar cell\u2010predominated. Human\n                    <jats:styled-content style=\"fixed-case\">SMG<\/jats:styled-content>\n                    s were mixed glands containing fewer mucous cells than porcine\n                    <jats:styled-content style=\"fixed-case\">SMG<\/jats:styled-content>\n                    s, whereas the acinar cells of murine\n                    <jats:styled-content style=\"fixed-case\">SMG<\/jats:styled-content>\n                    s are seromucous. The histological features of the duct system in the porcine and human\n                    <jats:styled-content style=\"fixed-case\">SMG<\/jats:styled-content>\n                    s were similar and included intercalated, striated and excretory ducts, but the murine\n                    <jats:styled-content style=\"fixed-case\">SMG<\/jats:styled-content>\n                    contained a specific structure, the granular convoluted tubule.\n                    <jats:styled-content style=\"fixed-case\">TJ<\/jats:styled-content>\n                    proteins, including claudin\u20101 to claudin\u201012, occludin and zonula occludin\u20101 (\n                    <jats:styled-content style=\"fixed-case\">ZO<\/jats:styled-content>\n                    \u20101), were detected in the porcine major salivary glands and human\n                    <jats:styled-content style=\"fixed-case\">SMG<\/jats:styled-content>\n                    s by\n                    <jats:styled-content style=\"fixed-case\">RT<\/jats:styled-content>\n                    \u2010\n                    <jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content>\n                    ; however, claudin\u20106, claudin\u20109 and claudin\u201011 were not detected in the murine\n                    <jats:styled-content style=\"fixed-case\">SMG<\/jats:styled-content>\n                    . As shown by immunofluorescence, claudin\u20101, claudin\u20103, claudin\u20104, occludin and\n                    <jats:styled-content style=\"fixed-case\">ZO<\/jats:styled-content>\n                    \u20101 were distributed in both acinar and ductal cells in the porcine and human\n                    <jats:styled-content style=\"fixed-case\">SMG<\/jats:styled-content>\n                    s, whereas claudin\u20101 and claudin\u20103 were mainly present in acinar cells, and claudin\u20104 was mainly distributed in ductal cells in the murine\n                    <jats:styled-content style=\"fixed-case\">SMG<\/jats:styled-content>\n                    . In addition, 3D images showed that the\n                    <jats:styled-content style=\"fixed-case\">TJ<\/jats:styled-content>\n                    proteins arranged in a honeycomb\u2010like structure on the luminal surface of the ducts, whereas their arrangements in acini were irregular in porcine\n                    <jats:styled-content style=\"fixed-case\">SMG<\/jats:styled-content>\n                    s. In summary, the expression pattern of\n                    <jats:styled-content style=\"fixed-case\">TJ<\/jats:styled-content>\n                    proteins in salivary glands is similar between human and miniature pig, which may be a candidate animal for studies on salivary gland\n                    <jats:styled-content style=\"fixed-case\">TJ<\/jats:styled-content>\n                    function.\n                  <\/jats:p>","DOI":"10.1111\/joa.12833","type":"journal-article","created":{"date-parts":[[2018,5,31]],"date-time":"2018-05-31T04:24:59Z","timestamp":1527740699000},"page":"167-176","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Expression patterns of tight junction proteins in porcine major salivary glands: a comparison study with human and murine glands"],"prefix":"10.1111","volume":"233","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5231-1220","authenticated-orcid":false,"given":"Xue\u2010Ming","family":"Zhang","sequence":"first","affiliation":[{"name":"Center for Salivary Gland Diseases Department of Oral and Maxillofacial Surgery Peking University School and Hospital of Stomatology Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Huang","sequence":"additional","affiliation":[{"name":"Center for Salivary Gland Diseases Department of Oral and Maxillofacial Surgery Peking University School and Hospital of Stomatology Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuo","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Laboratory Animal Science Peking University Health Science Center Beijing 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China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li\u2010Ling","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pathophysiology Key Laboratory of Molecular Cardiovascular Sciences Ministry of Education and Beijing Key Laboratory of Cardiovascular Receptors Research Peking University School of Basic Medical Sciences Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guang\u2010Yan","family":"Yu","sequence":"additional","affiliation":[{"name":"Center for Salivary Gland Diseases Department of Oral and Maxillofacial Surgery Peking University School and Hospital of Stomatology Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pathophysiology Key Laboratory of Molecular Cardiovascular Sciences Ministry of Education and Beijing Key Laboratory of Cardiovascular Receptors 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