{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T11:32:10Z","timestamp":1784201530353,"version":"3.55.0"},"reference-count":34,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,12,7]],"date-time":"2018-12-07T00:00:00Z","timestamp":1544140800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Anatomy"],"published-print":{"date-parts":[[2019,2]]},"abstract":"Abstract<\/jats:title>The aim of this study was to analyse the anatomy of the ventricular septal defect (VSD<\/jats:styled-content>) in heart specimens with interruption of the aortic arch (IAA<\/jats:styled-content>) in order to explore the hypothesis of different embryologic mechanisms for the different anatomic types of IAA<\/jats:styled-content>. We examined 42 human heart specimens, 25 with IAA<\/jats:styled-content> as the main disease with concordant atrioventricular and ventriculo\u2010arterial connections and two distinct great arteries, and 17 hearts with IAA<\/jats:styled-content> associated with other malformations [six common arterial trunk (CAT<\/jats:styled-content>), five double\u2010outlet right ventricle (DORV<\/jats:styled-content>), three transposition of the great arteries (TGA<\/jats:styled-content>), three atrioventricular septal defect (AVSD<\/jats:styled-content>)]. The interruption was classified according to Celoria and Patton. We focused on the anatomy of the VSD<\/jats:styled-content> viewed from the right ventricular side. There were 15 IAA<\/jats:styled-content> type A, 27 type B, no type C. The VSD<\/jats:styled-content> in IAA<\/jats:styled-content> type B was always an outlet VSD<\/jats:styled-content>, located between the two limbs of the septal band, with posterior malalignment of the outlet septum in hearts with concordant ventriculo\u2010arterial connections, without any fibrous tricuspid\u2010aortic continuity. In addition, the aortic arch was always completely absent. Conversely, the VSD<\/jats:styled-content> in IAA<\/jats:styled-content> type A could be of any type (outlet in six, muscular in four, central perimembranous in two, inlet in three) and the aortic arch was either atretic or absent. In addition, IAA<\/jats:styled-content> type B, when found in the setting of another anomaly, was always associated with neural crest\u2010related anomalies (CAT<\/jats:styled-content> and DORV<\/jats:styled-content>), whereas IAA<\/jats:styled-content> type A was found in association with anomalies not related to the neural crest (TGA<\/jats:styled-content> and AVSD<\/jats:styled-content>). These results reinforce the hypothesis that different pathogenic mechanisms are responsible for the two types of IAA<\/jats:styled-content>, and the inclusion of IAA<\/jats:styled-content> type B in the group of neural crest defects. Conversely, IAA<\/jats:styled-content> type A could be due to overlapping mechanisms: flow\u2010related defect (coarctation\u2010like) and neural crest contribution.<\/jats:p>","DOI":"10.1111\/joa.12911","type":"journal-article","created":{"date-parts":[[2018,12,7]],"date-time":"2018-12-07T12:44:40Z","timestamp":1544186680000},"page":"193-200","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["A new anatomic approach of the ventricular septal defect in the interruption of the aortic arch"],"prefix":"10.1111","volume":"234","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9143-9366","authenticated-orcid":false,"given":"Meriem","family":"Mostefa Kara","sequence":"first","affiliation":[{"name":"Paediatric Cardiology Centre de R\u00e9f\u00e9rence Malformations Cardiaques Cong\u00e9nitales Complexes \u2013 M3C Necker Hospital for Sick Children Assistance Publique des H\u00f4pitaux de Paris Paris France"},{"name":"Universit\u00e9 Paris Descartes Sorbonne Paris Cit\u00e9 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucile","family":"Houyel","sequence":"additional","affiliation":[{"name":"Congenital Cardiac Surgery H\u00f4pital Marie\u2010Lannelongue Le Plessis\u2010Robinson France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damien","family":"Bonnet","sequence":"additional","affiliation":[{"name":"Paediatric Cardiology Centre de R\u00e9f\u00e9rence Malformations Cardiaques Cong\u00e9nitales Complexes \u2013 M3C Necker Hospital for Sick Children Assistance Publique des H\u00f4pitaux de Paris Paris France"},{"name":"Universit\u00e9 Paris Descartes Sorbonne Paris Cit\u00e9 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,12,7]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"773","volume-title":"Osler's Modern Medicine","author":"Abbott 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