{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T00:23:28Z","timestamp":1772670208406,"version":"3.50.1"},"reference-count":169,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,2,21]],"date-time":"2019-02-21T00:00:00Z","timestamp":1550707200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Anatomy"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The Zika virus (<jats:styled-content style=\"fixed-case\">ZIKV<\/jats:styled-content>) became a major worldwide public concern in 2015 due to the congenital syndrome which presents the highest risk during the first trimester of pregnancy and includes microcephaly and eye malformations. Several cellular, genetic and molecular studies have shown alterations in metabolic pathways, endoplasmic reticulum (<jats:styled-content style=\"fixed-case\">ER)<\/jats:styled-content> stress, immunity and dysregulation of <jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> and energy metabolism both <jats:italic>in\u00a0vivo<\/jats:italic> and <jats:italic>in\u00a0vitro<\/jats:italic>. Here we summarise the main metabolic complications, with a particular focus on the possibility that brain energy metabolism is altered following <jats:styled-content style=\"fixed-case\">ZIKV<\/jats:styled-content> infection, contributing to developmental abnormalities. Brain energetic failure has been implicated in neurological conditions such as autism disorder and epilepsy, as well as in metabolic diseases with severe neurodevelopmental complications such as Glut\u20101 deficiency syndrome. Therefore, these energetic alterations are of wide\u2010ranging interest as they might be directly implicated in congenital <jats:styled-content style=\"fixed-case\">ZIKV<\/jats:styled-content> syndrome. Data showing increased glycolysis during <jats:styled-content style=\"fixed-case\">ZIKV<\/jats:styled-content> infection, presumably required for viral replication, might support the idea that the virus can cause energetic stress in the developing brain cells. Consequences may include neuroinflammation, cell cycle dysregulation and cell death. Ketone bodies are non\u2010glycolytic brain fuels that are produced during neonatal life, starvation or fasting, ingestion of high\u2010fat low\u2010carbohydrate diets, and following supplementation with ketone esters. We propose that dietary ketones might alter the course of the disease and could even provide some degree of prevention of <jats:styled-content style=\"fixed-case\">ZIKV<\/jats:styled-content>\u2010associated abnormalities and potentially related neurological conditions characterised by brain glucose impairment.<\/jats:p>","DOI":"10.1111\/joa.12959","type":"journal-article","created":{"date-parts":[[2019,2,22]],"date-time":"2019-02-22T04:02:24Z","timestamp":1550808144000},"page":"468-480","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["The potential contribution of impaired brain glucose metabolism to congenital Zika syndrome"],"prefix":"10.1111","volume":"235","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1268-2304","authenticated-orcid":false,"given":"Javier","family":"Gilbert\u2010Jaramillo","sequence":"first","affiliation":[{"name":"Department of Physiology, Anatomy and Genetics University of Oxford Oxford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia","family":"Garcez","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Sciences Federal University of Rio de Janeiro Rio de Janeiro Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William","family":"James","sequence":"additional","affiliation":[{"name":"Sir William Dunn School of Pathology University of Oxford Oxford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6852-6004","authenticated-orcid":false,"given":"Zolt\u00e1n","family":"Moln\u00e1r","sequence":"additional","affiliation":[{"name":"Department of Physiology, Anatomy and Genetics University of Oxford Oxford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kieran","family":"Clarke","sequence":"additional","affiliation":[{"name":"Department of Physiology, Anatomy and Genetics University of Oxford Oxford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,2,21]]},"reference":[{"issue":"2","key":"e_1_2_9_2_1","first-page":"93","article-title":"Posterior fossa in primary microcephaly: relationships between forebrain and mid\u2010hindbrain size in 110 patients","volume":"45","author":"Adachi Y","year":"2014","journal-title":"Neuropediatrics"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/aww158"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(17)30408-8"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.21974"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.12119"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2016.03.008"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2011.08.016"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid2303.161499"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.5501\/wjv.v5.i4.135"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2014.00266"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(16)30062-7"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI112299"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1602412"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2016.07.018"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2015.08.031"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10495-013-0930-7"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.nutr.26.061505.111258"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(16)00095-5"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.15252\/embj.201695810"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-015-1700-4"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid2006.140138"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2007.04631.x"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-008-0526-1"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)00651-6"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.7326\/M16-0150"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18081714"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0006007"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0005528"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/iub.1224"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.192369"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms161226095"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature18296"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0000000000001486"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-01923-4"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2017.517"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.22738"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(52)90042-4"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.10079"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0805715"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep35296"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aag3194"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1089\/vim.2010.0126"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1186\/1755-8794-8-S1-S4"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms161125939"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaophthalmol.2017.3595"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02309-14"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaf6116"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep40780"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-31149-3"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1209126"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apjtb.2016.08.008"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1002\/wdev.89"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-017-0038-4"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17122093"},{"issue":"5","key":"e_1_2_9_56_1","first-page":"618","article-title":"Neonatal energy substrate production","volume":"130","author":"Gustafsson J","year":"2009","journal-title":"Indian J Med Res"},{"key":"e_1_2_9_57_1","first-page":"321","article-title":"Placental\u2010fetal glucose exchange and fetal glucose metabolism","volume":"117","author":"Hay W W","year":"2006","journal-title":"Trans Am Clin Climatol Assoc"},{"issue":"3","key":"e_1_2_9_58_1","first-page":"R569","article-title":"Model of placental glucose consumption and glucose transfer","volume":"258","author":"Hay WW","year":"1990","journal-title":"Am J Physiol"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid1509.090442"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2010.10.006"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.3390\/v3081332"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1881"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm3270"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)00320-2"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-11103-5"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0117084"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.19006"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00093.2009"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2016.06.026"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0831078100"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaophthalmol.2016.0284"},{"key":"e_1_2_9_72_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M601881200"},{"key":"e_1_2_9_73_1","unstructured":"Jimena BarbeitoA PezzutoP HigaLM et\u00a0al. (2018a)Exploring brain phenotypic outcomes when Zika virus and protein undernutrition interact during early development 165(1) 18\u201319."},{"key":"e_1_2_9_74_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.2006592"},{"key":"e_1_2_9_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coviro.2016.05.007"},{"key":"e_1_2_9_76_1","doi-asserted-by":"publisher","DOI":"10.4149\/endo_2014_01_35"},{"key":"e_1_2_9_77_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2010.06728.x"},{"key":"e_1_2_9_78_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm6509e2"},{"key":"e_1_2_9_79_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2008.01833.x"},{"key":"e_1_2_9_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.plefa.2003.07.004"},{"key":"e_1_2_9_81_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2005-872843"},{"key":"e_1_2_9_82_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00457.2003"},{"key":"e_1_2_9_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-4642(18)30020-8"},{"key":"e_1_2_9_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2016.03.010"},{"key":"e_1_2_9_85_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00113.2016"},{"key":"e_1_2_9_86_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-18909-3"},{"key":"e_1_2_9_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2017.02.012"},{"key":"e_1_2_9_88_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41421-018-0042-1"},{"key":"e_1_2_9_89_1","doi-asserted-by":"publisher","DOI":"10.11622\/smedj.2017026"},{"key":"e_1_2_9_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.12.019"},{"key":"e_1_2_9_91_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/2525967"},{"key":"e_1_2_9_92_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2017.15"},{"key":"e_1_2_9_93_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2015.06.007"},{"key":"e_1_2_9_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.11.016"},{"key":"e_1_2_9_95_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2006.11.065"},{"key":"e_1_2_9_96_1","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.1999.0471"},{"key":"e_1_2_9_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/1044-7431(91)90066-W"},{"key":"e_1_2_9_98_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)30883-2"},{"key":"e_1_2_9_99_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.192500"},{"key":"e_1_2_9_100_1","doi-asserted-by":"publisher","DOI":"10.1002\/wdev.273"},{"key":"e_1_2_9_101_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddx382"},{"key":"e_1_2_9_102_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.15272"},{"key":"e_1_2_9_103_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2017.01.004"},{"key":"e_1_2_9_104_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2016.08.079"},{"key":"e_1_2_9_105_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2016.11.014"},{"key":"e_1_2_9_106_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1600651"},{"key":"e_1_2_9_107_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10545-005-5518-0"},{"key":"e_1_2_9_108_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00009-17"},{"key":"e_1_2_9_109_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/76.1.65"},{"key":"e_1_2_9_110_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2015.04.021"},{"key":"e_1_2_9_111_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-032713-120240"},{"key":"e_1_2_9_112_1","doi-asserted-by":"publisher","DOI":"10.1590\/0074-02760160085"},{"key":"e_1_2_9_113_1","doi-asserted-by":"publisher","DOI":"10.1002\/bmb.2005.49403304246"},{"key":"e_1_2_9_114_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI105650"},{"key":"e_1_2_9_115_1","first-page":"1","article-title":"Zika virus disease in Colombia \u2013 preliminary report","author":"Pacheco O","year":"2016","journal-title":"N Engl J Med"},{"key":"e_1_2_9_116_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/472459"},{"key":"e_1_2_9_117_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaophthalmol.2016.0267"},{"key":"e_1_2_9_118_1","doi-asserted-by":"publisher","DOI":"10.1097\/ICU.0000000000000420"},{"key":"e_1_2_9_119_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-1136(199711)21:3<327::AID-GLIA7>3.0.CO;2-1"},{"key":"e_1_2_9_120_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.22.10625"},{"key":"e_1_2_9_121_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2016.02.001"},{"key":"e_1_2_9_122_1","doi-asserted-by":"publisher","DOI":"10.1590\/0004-282x20160138"},{"key":"e_1_2_9_123_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coviro.2017.09.005"},{"key":"e_1_2_9_124_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.04.032"},{"key":"e_1_2_9_125_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jiph.2016.05.007"},{"key":"e_1_2_9_126_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-0895(199812)14:4<263::AID-DMR233>3.0.CO;2-C"},{"key":"e_1_2_9_127_1","doi-asserted-by":"publisher","DOI":"10.12965\/jer.140160"},{"key":"e_1_2_9_128_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(17)30123-7"},{"key":"e_1_2_9_129_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2016.12.015"},{"key":"e_1_2_9_130_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2016.06.009"},{"key":"e_1_2_9_131_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2010.136"},{"key":"e_1_2_9_132_1","article-title":"Zika virus and the metabolism of neuronal cells","author":"Rothan HA","year":"2018","journal-title":"Mol Neurobiol"},{"key":"e_1_2_9_133_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000632"},{"key":"e_1_2_9_134_1","doi-asserted-by":"publisher","DOI":"10.1590\/0074-02760160149"},{"key":"e_1_2_9_135_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2013.06.028"},{"key":"e_1_2_9_136_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature20564"},{"key":"e_1_2_9_137_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0004517"},{"key":"e_1_2_9_138_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2016.06.028"},{"key":"e_1_2_9_139_1","doi-asserted-by":"publisher","DOI":"10.1053\/plac.2002.0869"},{"key":"e_1_2_9_140_1","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2013.128"},{"key":"e_1_2_9_141_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-08894-5_2"},{"key":"e_1_2_9_142_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm6623e1"},{"key":"e_1_2_9_143_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2017.00110"},{"key":"e_1_2_9_144_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1095505"},{"key":"e_1_2_9_145_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-21894-w"},{"key":"e_1_2_9_146_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0191147"},{"key":"e_1_2_9_147_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(16)00125-0"},{"key":"e_1_2_9_148_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep39775"},{"key":"e_1_2_9_149_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2012.00050"},{"key":"e_1_2_9_150_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2016.02.016"},{"key":"e_1_2_9_151_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms14152"},{"key":"e_1_2_9_152_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201500182"},{"key":"e_1_2_9_153_1","doi-asserted-by":"publisher","DOI":"10.1038\/emi.2017.9"},{"key":"e_1_2_9_154_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12985-017-0685-9"},{"key":"e_1_2_9_155_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2018.00010"},{"key":"e_1_2_9_156_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.13552"},{"key":"e_1_2_9_157_1","doi-asserted-by":"publisher","DOI":"10.5935\/0004-2749.20160002"},{"key":"e_1_2_9_158_1","doi-asserted-by":"publisher","DOI":"10.4103\/0972-2327.91946"},{"key":"e_1_2_9_159_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2015.01.022"},{"key":"e_1_2_9_160_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2018.02.118"},{"key":"e_1_2_9_161_1","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.02063-16"},{"key":"e_1_2_9_162_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2015.04.004"},{"key":"e_1_2_9_163_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.298216.117"},{"key":"e_1_2_9_164_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2004.01.003"},{"key":"e_1_2_9_165_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02749-15"},{"key":"e_1_2_9_166_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2016.04.019"},{"key":"e_1_2_9_167_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.08.004"},{"key":"e_1_2_9_168_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2011.04.002"},{"key":"e_1_2_9_169_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01967-10"},{"key":"e_1_2_9_170_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkw765"}],"container-title":["Journal of Anatomy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjoa.12959","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/joa.12959","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/joa.12959","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/joa.12959","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T20:47:44Z","timestamp":1694119664000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/joa.12959"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2,21]]},"references-count":169,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,9]]}},"alternative-id":["10.1111\/joa.12959"],"URL":"https:\/\/doi.org\/10.1111\/joa.12959","archive":["Portico"],"relation":{},"ISSN":["0021-8782","1469-7580"],"issn-type":[{"value":"0021-8782","type":"print"},{"value":"1469-7580","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,2,21]]},"assertion":[{"value":"2019-01-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-02-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}