{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T15:32:12Z","timestamp":1766158332841,"version":"3.40.5"},"reference-count":19,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,5,30]],"date-time":"2019-05-30T00:00:00Z","timestamp":1559174400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001824","name":"Grantov\u00e1 Agentura \u010cesk\u00e9 Republiky","doi-asserted-by":"publisher","award":["GA CR 16\u201018430S"],"award-info":[{"award-number":["GA CR 16\u201018430S"]}],"id":[{"id":"10.13039\/501100001824","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Anatomy"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">FASL<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>178) is known for its role in triggering apoptosis, mostly in relation with immune cells but additional functions have been reported more recently, including those in bone development. Examination of postnatal <jats:italic>FasL<\/jats:italic>\u2010deficient mice (<jats:italic>gld<\/jats:italic>) showed an increased bone deposition in adult mice when compared with wild types. However, a different phenotype was observed prenatally, when the <jats:italic>gld<\/jats:italic> bone was underdeveloped. The aim of the following investigation was to evaluate this indication for an growth\u2010dependent bone phenotype of <jats:italic>gld<\/jats:italic> mice and to search for the \u2018switch point\u2019. This study focused on the mandibular\/alveolar bone as an important structure for tooth anchorage. <jats:italic>In vivo<\/jats:italic> micro\u2010<jats:styled-content style=\"fixed-case\">computed tomography (CT)<\/jats:styled-content> analysis was performed at different stages during the first month (6, 12 and 24\u00a0days) of postnatal bone development. In 6\u2010day\u2010old <jats:italic>gld<\/jats:italic> mice, a decrease in bone volume\/tissue volume (<jats:styled-content style=\"fixed-case\">BV<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">TV<\/jats:styled-content>), trabecular thickness and trabecular number was revealed. In contrast, the 12\u2010day\u2010old <jats:italic>gld<\/jats:italic> mice showed an increased <jats:styled-content style=\"fixed-case\">BV<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">TV<\/jats:styled-content> and trabecular thickness in the alveolar bone. The same observation applied for bone status in 24\u2010day\u2010old <jats:italic>gld<\/jats:italic> mice. Therefore, changes in the bone phenotype occurred between day 6 and 12 of the postnatal development. The switch point is likely related to the changing proportion of bone cells at these stages of development, when the number of osteocytes increases. Indeed, the immunohistochemical analysis of <jats:styled-content style=\"fixed-case\">FASL<\/jats:styled-content> localized this protein in osteoblasts, whereas osteocytes were mostly negative at examined stages. The impact of <jats:styled-content style=\"fixed-case\">FASL<\/jats:styled-content> particularly on osteoblasts would agree with an earlier <jats:italic>in vivo<\/jats:italic> observed effect of <jats:styled-content style=\"fixed-case\">FASL<\/jats:styled-content> deficiency on expression of <jats:italic>Mmp2<\/jats:italic>, typical for osteoblasts, in the <jats:italic>gld<\/jats:italic> mandibular\/alveolar bone. Notably, an age\u2010dependent bone phenotype was reported in <jats:italic>Mmp2<\/jats:italic>\u2010deficient mice.<\/jats:p>","DOI":"10.1111\/joa.13015","type":"journal-article","created":{"date-parts":[[2019,5,31]],"date-time":"2019-05-31T02:23:45Z","timestamp":1559269425000},"page":"256-261","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Growth\u2010dependent phenotype in <i>FasL<\/i>\u2010deficient mandibular\/alveolar bone"],"prefix":"10.1111","volume":"235","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9966-0794","authenticated-orcid":false,"given":"Eva","family":"Svandova","sequence":"first","affiliation":[{"name":"Department of Physiology University of Veterinary and Pharmaceutical Sciences Brno Czech Republic"},{"name":"Institute of Animal Physiology and Genetics Academy of Sciences Brno Czech 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Physiology and Genetics Academy of Sciences Brno Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne","family":"Poliard","sequence":"additional","affiliation":[{"name":"Laboratory of Orofacial Pathologies, Imaging and Biotherapies Universit\u00e9 Paris Descartes Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva","family":"Matalova","sequence":"additional","affiliation":[{"name":"Department of Physiology University of Veterinary and Pharmaceutical Sciences Brno Czech Republic"},{"name":"Institute of Animal Physiology and Genetics Academy of Sciences Brno Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,5,30]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034510378427"},{"key":"e_1_2_6_3_1","doi-asserted-by":"crossref","first-page":"3649","DOI":"10.1242\/jcs.108.12.3649","article-title":"Matrix 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