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Remnants of their toothed ancestry can be found in their ontogeny, as they still develop tooth germs <jats:italic>in utero<\/jats:italic>. Understanding the developmental transition from teeth to baleen and the associated skull modifications in prenatal specimens of extant species can enhance our understanding of the evolutionary history of this lineage by using ontogeny as a relative proxy of the evolutionary changes observed in the fossil record. Although at present very little information is available on prenatal development of baleen whales, especially regarding tooth resorption and baleen formation, due to a lack of specimens. Here I present the first detailed description of prenatal specimens of minke whales (<jats:italic>Balaenoptera acutorostrata<\/jats:italic> and <jats:italic>Balaenoptera bonaerensis<\/jats:italic>), focusing on the skull anatomy and tooth germ development, resorption, and baleen growth. The ontogenetic sequence described consists of 10 specimens of both minke whale species, from the earliest fetal stages to full term. The internal skull anatomy of the specimens was visualized using traditional and iodine\u2010enhanced computed tomography scanning. These high\u2010quality data allow detailed description of skull development both qualitatively and quantitatively using three\u2010dimensional landmark analysis. I report distinctive external anatomical changes and the presence of a denser tissue medial to the tooth germs in specimens from the final portion of gestation, which can be interpreted as the first signs of baleen formation (baleen rudiments). Tooth germs are only completely resorbed just before the eruption of the baleen from the gums, and they are still present for a brief period with baleen rudiments. Skull shape development is characterized by progressive elongation of the rostrum relative to the braincase and by the relative anterior movement of the supraoccipital shield, contributing to a defining feature of cetaceans, telescoping. These data aid the interpretation of fossil morphologies, especially of those extinct taxa where there is no direct evidence of presence of baleen, even if caution is needed when comparing prenatal extant specimens with adult fossils. The ontogeny of other mysticete species needs to be analyzed before drawing definitive conclusions about the influence of development on the evolution of this group. Nonetheless, this work is the first step towards a deeper understanding of the most distinctive patterns in prenatal skull development of baleen whales, and of the anatomical changes that accompany the transition from tooth germs to baleen. It also presents comprehensive hypotheses to explain the influence of developmental processes on the evolution of skull morphology and feeding adaptations of mysticetes.<\/jats:p>","DOI":"10.1111\/joa.13029","type":"journal-article","created":{"date-parts":[[2019,6,19]],"date-time":"2019-06-19T13:51:11Z","timestamp":1560952271000},"page":"725-748","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Prenatal developmental sequence of the skull of minke whales and its implications for the evolution of mysticetes and the teeth\u2010to\u2010baleen transition"],"prefix":"10.1111","volume":"235","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1364-0544","authenticated-orcid":false,"given":"Agnese","family":"Lanzetti","sequence":"first","affiliation":[{"name":"Department of Biology San Diego State University San Diego CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,6,19]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"155","article-title":"Die Vorfahren der Bartenwale","volume":"90","author":"Abel O","year":"1914","journal-title":"Denk Kais Akad Wiss Math Natwiss Clas"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-7692.2010.00445.x"},{"key":"e_1_2_9_4_1","unstructured":"BandoT NakaiK KanbayashiJ et\u00a0al. 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