{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T12:13:26Z","timestamp":1789647206296,"version":"4.0.0"},"reference-count":39,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,9,9]],"date-time":"2019-09-09T00:00:00Z","timestamp":1567987200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Anatomy"],"published-print":{"date-parts":[[2020,1]]},"abstract":"Abstract<\/jats:title>\n \n Omental milky spots (\n OMS<\/jats:styled-content>\n s), small lymphoid structures positioned in the greater omentum, are involved in peritoneal immune homeostasis and the formation of omental metastases. Sympathetic nerve activity is known to regulate immune function in other lymphoid organs (e.g. spleen and lymph nodes) and to create a favourable microenvironment for various tumour types. However, it is still unknown whether\n OMS<\/jats:styled-content>\n s receive sympathetic innervation. Therefore, the aim of this study was to establish whether\n OMS<\/jats:styled-content>\n s of the adult human greater omentum receive sympathetic innervation. A total of 18\n OMS<\/jats:styled-content>\n s were isolated from five omenta, which were removed from 3% formaldehyde\u2010perfused cadavers (with a median age of 84\u00a0years, ranging from 64 to 94).\n OMS<\/jats:styled-content>\n s were embedded in paraffin, cut and stained with a general (\n PGP<\/jats:styled-content>\n 9.5) and sympathetic nerve marker (\n TH<\/jats:styled-content>\n and\n DBH<\/jats:styled-content>\n ), and evaluated by bright field microscopy. A T\u2010cell, B\u2010cell, and macrophage staining was performed to confirm\n OMS<\/jats:styled-content>\n identity. In 50% of the studied\n OMS<\/jats:styled-content>\n s, sympathetic nerve fibres were observed at multiple levels of the same\n OMS<\/jats:styled-content>\n . Nerve fibres were represented as dots or elongated structures and often observed in relation to small vessels and occasionally as individual structures residing between lymphoid cells. The current study shows that 50% of the investigated\n OMS<\/jats:styled-content>\n s contain sympathetic nerve fibres. These findings may contribute to our understanding of neural regulation of peritoneal immune response and the involvement of\n OMS<\/jats:styled-content>\n s in omental metastases.\n <\/jats:p>","DOI":"10.1111\/joa.13077","type":"journal-article","created":{"date-parts":[[2019,9,9]],"date-time":"2019-09-09T11:34:26Z","timestamp":1568028866000},"page":"156-164","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Sympathetic nerve tissue in milky spots of the human greater omentum"],"prefix":"10.1111","volume":"236","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4993-3736","authenticated-orcid":false,"given":"Cindy G. 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