{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T20:45:37Z","timestamp":1788468337707,"version":"build-2803163510"},"reference-count":24,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,10,31]],"date-time":"2019-10-31T00:00:00Z","timestamp":1572480000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","award":["\u2018Com3d\u2010XCT\u2019 (Interreg ATCZ38)"],"award-info":[{"award-number":["\u2018Com3d\u2010XCT\u2019 (Interreg ATCZ38)"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Anatomy"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Gross features of disc degeneration (DD) that are associated with back pain include tears in the anulus fibrosus, structural changes of the endplates, and a collapse of the anulus. The aim of this study is the detailed visualization and microstructural characterization of DD using microcomputed tomography (\u03bcCT) and a dedicated image post\u2010processing pipeline. In detail, we investigate a cadaveric spine that shows both types of DD between L1 and L2 and between L2 and L3, respectively. The lumbar spine was obtained from a male donor aged 74\u00a0years. The complete specimen was scanned using \u03bcCT with an isometric voxel size of 93\u00a0\u03bcm. Subsequently, regions of interest (ROI) were prepared featuring each complete intervertebral disc including the adjacent endplates. ROIs were then additionally scanned with a voxel size of 35\u00a0\u03bcm and by means of magnetic resonance imaging. The collapsed endplate of the superior L2 showed explicit signs of an endplate\u2010driven degeneration, including bony endplate failures. In contrast, the intervertebral disc between L2 and L3 showed indications of an annulus\u2010driven DD including severe disc height loss and concentric tears. Using \u03bcCT we were able to visualize and quantify bone and cartilage features in DD. We showed that in both cases a suite of structural changes accompanies cartilage degeneration, including microstructural bony adaptions to counteract changes in the biomechanical loading regimen.<\/jats:p>","DOI":"10.1111\/joa.13105","type":"journal-article","created":{"date-parts":[[2019,10,31]],"date-time":"2019-10-31T07:58:12Z","timestamp":1572508692000},"page":"243-251","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Visualization of intervertebral disc degeneration in a cadaveric human lumbar spine using microcomputed tomography"],"prefix":"10.1111","volume":"236","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8400-5121","authenticated-orcid":false,"given":"Sascha","family":"Senck","sequence":"first","affiliation":[{"name":"University of Applied Sciences Upper Austria Wels 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makroskopische und klinische Anatomie Graz Medizinische Universit\u00e4t Graz Graz Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,10,31]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7580.2012.01551.x"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.65B2.6826631"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.brs.0000231761.73859.2c"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.78B6.0780965"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ca.22404"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s005860050058"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2007.07.007"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncprheum0293"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)02135-1"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2017.03.158"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.3109\/ort.1967.38.suppl-100.01"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2015.00038"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7580.2010.01227.x"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/BRS.0b013e31815a59a0"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007632-199204000-00007"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2818.1997.1340694.x"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-007-0478-x"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/BRS.0b013e3181d534f3"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2010.09.010"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007632-199509000-00007"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00586-009-0918-8"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/BRS.0b013e318263ba59"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200201)46:1<114::AID-ART10025>3.0.CO;2-P"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00586-011-1922-3"}],"container-title":["Journal 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