{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T22:15:47Z","timestamp":1787350547392,"version":"build-2736575974"},"reference-count":17,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,3,2]],"date-time":"2020-03-02T00:00:00Z","timestamp":1583107200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Anatomy"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Cardiac arrhythmias, notably Wolff\u2010Parkinson\u2010White syndrome, are known to represent a major issue in patients with Ebstein\u2019s malformation of the tricuspid valve. Abnormal conducting circuits, however, can also be produced by pathways extending either from the atrioventricular node or the ventricular components of the atrioventricular conduction axis, direct to the crest of the muscular ventricular septum. We hoped to provide further information on the potential presence of such pathways by investigations of six autopsied examples of Ebstein\u2019s malformation. All were studied by histological sectioning on the full extent of the atrioventricular conduction axis, with limited sectioning of the right atrioventricular junction supporting the inferior and antero\u2010superior leaflets of the deformed tricuspid valve. We used the criteria established by Aschoff (<jats:italic>Verhandlungen der Deutschen Gesellschaft f\u00fcr Pathologie<\/jats:italic>, 14, 1910, 3) and M\u00f6nckeberg (<jats:italic>Verhandlungen der Deutschen Gesellschaft f\u00fcr Pathologie<\/jats:italic>, 14, 1910, 64) over a century ago to define abnormal connections across the atrioventricular junctions, as these definitions retain their validity for the identification of gross myocardial connections across the insulating tissues of the atrioventricular junctions. In one specimen, we found two discrete accessory myocardial connections across the parietal right atrioventricular junction. In all of the hearts, we found so\u2010called nodoventricular connections, and in one heart we also observed a well\u2010formed connection originating from the penetrating atrioventricular bundle. In addition to accessory myocardial connections across the parietal right atrioventricular junction, therefore, our histological findings demonstrate a potential role for direct connections between the atrioventricular conduction axis and the ventricular myocardium in the setting of Ebstein\u2019s malformation.<\/jats:p>","DOI":"10.1111\/joa.13179","type":"journal-article","created":{"date-parts":[[2020,3,2]],"date-time":"2020-03-02T09:25:05Z","timestamp":1583141105000},"page":"155-165","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Histological examination of the potential arrhythmic substrates in the setting of Ebstein\u2019s malformation"],"prefix":"10.1111","volume":"237","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5374-8317","authenticated-orcid":false,"given":"Dami\u00e1n","family":"S\u00e1nchez\u2010Quintana","sequence":"first","affiliation":[{"name":"Department of Human Anatomy and Cell Biology Faculty of Medicine University of Extremadura Badajoz Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Angel","family":"Cabrera","sequence":"additional","affiliation":[{"name":"Unidad de Arritmias Departamento de Cardiolog\u00eda Hospital Universitario Quir\u00f3n\u2010Salud Madrid and Complejo Hospitalario Ruber Juan Bravo Universidad Europea de Madrid Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz","family":"Picazo\u2010Angelin","sequence":"additional","affiliation":[{"name":"Secci\u00f3n de Cardiolog\u00eda Pedi\u00e1trica Departamento de Enfermedades Cardiovasculares Hospita Regional Universitario Carlos Haya de M\u00e1laga M\u00e1laga Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Cabrera","sequence":"additional","affiliation":[{"name":"Servicio de Pediatr\u00eda Hospital Cruces Baracaldo Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5163-9021","authenticated-orcid":false,"given":"Robert H.","family":"Anderson","sequence":"additional","affiliation":[{"name":"Institute of Genetic Medicine Newcastle University Newcastle upon Tyne UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,3,2]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"547","article-title":"Micro\u2010Ebstein. Presentation of 3 cases and analysis of the literature","volume":"38","author":"Alitto F.","year":"1990","journal-title":"Minerva Cardioangiologica"},{"key":"e_1_2_7_3_1","first-page":"174","article-title":"Morphologic spectrum of Ebstein\u2019s anomaly of the heart: a review","volume":"54","author":"Anderson K.R.","year":"1979","journal-title":"Mayo Clinic Proceedings"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jce.14106"},{"key":"e_1_2_7_5_1","first-page":"3","article-title":"Referat uber die Herzstorungen in ihren Beziehungen zu den Spezifischen Muskelsystem des Herzens","volume":"14","author":"Aschoff L.","year":"1910","journal-title":"Verhandlungen der Deutschen Gesellschaft f\u00fcr Pathologie"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2019.07.025"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.57.5.870"},{"key":"e_1_2_7_8_1","first-page":"238","article-title":"Ueber einen sehr seltenen Fall von Insuffizienz der Valvula tricuspidalis, bedingt durch eine angeborene hochgradige Missbildung derselben","volume":"33","author":"Ebstein W.","year":"1866","journal-title":"Archiv f\u00fcr Anatomie, Physiologie und Wissenschaftliche Medicin,"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/heart.83.4.444"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(47)90080-X"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1159\/000164707"},{"key":"e_1_2_7_12_1","first-page":"64","article-title":"Beitrage zur normalen und pathologischen Anatomie des Herzens","volume":"14","author":"M\u00f6nckeberg J.G.","year":"1910","journal-title":"Verhandlungen der Deutschen Gesellschaft f\u00fcr Pathologie"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(84)90451-X"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5223(99)70480-0"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(83)80143-9"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.34.12.1263"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacep.2018.05.024"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.36.5.417"}],"container-title":["Journal of Anatomy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjoa.13179","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/joa.13179","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/joa.13179","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/joa.13179","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T23:41:03Z","timestamp":1693957263000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/joa.13179"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3,2]]},"references-count":17,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,7]]}},"alternative-id":["10.1111\/joa.13179"],"URL":"https:\/\/doi.org\/10.1111\/joa.13179","archive":["Portico"],"relation":{},"ISSN":["0021-8782","1469-7580"],"issn-type":[{"value":"0021-8782","type":"print"},{"value":"1469-7580","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,3,2]]},"assertion":[{"value":"2019-10-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-02-14","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-03-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}