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The ovarian bursa is considered as the structure facilitating the transport of ovulated oocytes into the oviduct. Our previous study revealed reduced oocyte pick\u2010up function in the oviduct of lupus\u2010prone MRL\/MpJ\u2010Fas<jats:italic><jats:sup>lpr<\/jats:sup><\/jats:italic><jats:sup>\/<\/jats:sup><jats:italic><jats:sup>lpr<\/jats:sup><\/jats:italic> mouse, suggesting the possibility of an escape of ovulated oocytes into the peritoneal cavity, despite the presence of an almost complete ovarian bursa in the mouse. In this study, we revealed anatomical and histological characteristics of the ovarian bursa in C57BL\/6\u00a0N, MRL\/MpJ, and MRL\/MpJ\u2010Fas<jats:italic><jats:sup>lpr<\/jats:sup><\/jats:italic><jats:sup>\/<\/jats:sup><jats:italic><jats:sup>lpr<\/jats:sup><\/jats:italic> mice. All strains had the foramen of ovarian bursa (FOB), with a size of approximately 0.04 to 0.12\u00a0cm<jats:sup>2<\/jats:sup>, surrounded by the ligament of ovarian bursa (LOB), which is part of the mesosalpinx. The LOB was partially lined with the cuboidal mesothelial cells and consisted of a thick smooth muscle layer in all strains. In 6\u2010month\u2010old MRL\/MpJ\u2010Fas<jats:italic><jats:sup>lpr<\/jats:sup><\/jats:italic><jats:sup>\/<\/jats:sup><jats:italic><jats:sup>lpr<\/jats:sup><\/jats:italic> mice, in which the systemic autoimmune abnormality deteriorated and oocyte pick\u2010up function was impaired, the size of the FOB tended to be larger than that of other strains. Additionally, in MRL\/MpJ\u2010Fas<jats:italic><jats:sup>lpr<\/jats:sup><\/jats:italic><jats:sup>\/<\/jats:sup><jats:italic><jats:sup>lpr<\/jats:sup><\/jats:italic> mice at 6\u00a0months of age, there was infiltration by numerous immune cells in the mesosalpinx suspending the isthmus; however, the LOB prevented severe inflammation and showed deposition of collagen fibers. These results not only indicate that the FOB is a common structure within mice, but also imply the physiological function of the LOB and its role in maintaining the microenvironment around the ovary, as well as regulating healthy reproduction.<\/jats:p>","DOI":"10.1111\/joa.13299","type":"journal-article","created":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T10:22:07Z","timestamp":1598955727000},"page":"73-85","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Anatomy and histology of the foramen of ovarian bursa opening to the peritoneal cavity and its changes in autoimmune disease\u2010prone mice"],"prefix":"10.1111","volume":"238","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0360-3360","authenticated-orcid":false,"given":"Marina","family":"Hosotani","sequence":"first","affiliation":[{"name":"Laboratory of Veterinary Anatomy Department of Veterinary Medicine School of Veterinary Medicine Rakuno Gakuen University Ebetsu Hokkaido Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osamu","family":"Ichii","sequence":"additional","affiliation":[{"name":"Laboratory of Anatomy Department of Basic Veterinary Science Faculty of Veterinary Medicine Hokkaido University Sapporo Hokkaido Japan"},{"name":"Laboratory of Agrobiomedical Science Faculty of Agriculture Hokkaido University Sapporo Hokkaido Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teppei","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Laboratory of Anatomy Department of Basic Veterinary Science Faculty of Veterinary Medicine Hokkaido University Sapporo Hokkaido Japan"},{"name":"Section of Biological Safety Research Chitose Laboratory Japan Food Research Laboratories Chitose Hokkaido Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Namba","sequence":"additional","affiliation":[{"name":"Laboratory of Anatomy Department of Basic Veterinary Science Faculty of Veterinary Medicine Hokkaido University Sapporo Hokkaido Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md. 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