{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T20:20:15Z","timestamp":1768681215411,"version":"3.49.0"},"reference-count":40,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,11,3]],"date-time":"2020-11-03T00:00:00Z","timestamp":1604361600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Anatomy"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Bilaterally symmetrical primordia of visceral organs undergo asymmetrical morphogenesis leading to typical arrangement of visceral organs in the adult. Asymmetrical morphogenesis within the upper abdomen leads, among others, to the formation of the omental bursa dorsally to the rotated stomach. A widespread view of this process assumes kinking of thin mesenteries as a main mechanism. This view is based on a theory proposed already by Johannes M\u00fcller in 1830 and was repeatedly criticized, but some of the most plausible alternative views (initially proposed by Swaen in 1897 and Broman in 1904) still remain to be proven. Here, we analyzed serial histological sections of human embryos between stages 12 and 15 at high light microscopical resolution to reveal the succession of events giving rise to the development of the omental bursa and its relation to the emerging stomach asymmetry. Our analysis indicates that morphological symmetry breaking in the upper abdomen occurs within a wide mesenchymal plate called here mesenteric septum and is based on differential behavior of the coelomic epithelium which causes asymmetric paragastric recess formation and, importantly, precedes initial rotation of stomach. Our results thus provide the first histological evidence of breaking the symmetry of the early foregut anlage in the human embryo and pave the way for experimental studies of left\u2010right symmetry breaking in the upper abdomen in experimental model organisms.<\/jats:p>","DOI":"10.1111\/joa.13344","type":"journal-article","created":{"date-parts":[[2020,11,4]],"date-time":"2020-11-04T02:20:26Z","timestamp":1604456426000},"page":"1010-1022","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Initial morphological symmetry breaking in the foregut and development of the omental bursa in human embryos"],"prefix":"10.1111","volume":"238","author":[{"given":"Tobias","family":"Sch\u00e4fer","sequence":"first","affiliation":[{"name":"Institute of Anatomy and Embryology University Medical Center G\u00f6ttingen G\u00f6ttingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Viktoria","family":"Stankova","sequence":"additional","affiliation":[{"name":"Institute of Anatomy and Embryology University Medical Center G\u00f6ttingen G\u00f6ttingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph","family":"Viebahn","sequence":"additional","affiliation":[{"name":"Institute of Anatomy and Embryology University Medical Center G\u00f6ttingen G\u00f6ttingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernadette","family":"de Bakker","sequence":"additional","affiliation":[{"name":"Department of Medical Biology Section Clinical Anatomy &amp; Embryology Academic Medical Center University of Amsterdam Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8871-5577","authenticated-orcid":false,"given":"Nikoloz","family":"Tsikolia","sequence":"additional","affiliation":[{"name":"Institute of Anatomy and Embryology University Medical Center G\u00f6ttingen G\u00f6ttingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,11,3]]},"reference":[{"key":"e_1_2_7_2_1","volume-title":"The embryonic development of the pneumato\u2010enteric recess","author":"Aben K.","year":"2012"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1159\/000087625"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2018.02.073"},{"key":"e_1_2_7_5_1","volume-title":"Die Entwicklungsgeschichte der Bursa omentalis und aehnlicher Rezessbildungen bei den Wirbeltieren","author":"Broman I.","year":"1904"},{"key":"e_1_2_7_6_1","volume-title":"\u00dcber die Entwickelung der Mesenterien der Leberligamente und der Leberform bei den Lungenfischen","author":"Broman I.","year":"1905"},{"key":"e_1_2_7_7_1","first-page":"195","article-title":"Warum wird die Entwicklung der Bursa omentalis in Lehrb\u00fcchern fortw\u00e4hrend unrichtig beschrieben?","volume":"86","author":"Broman I.","year":"1938","journal-title":"Anatomischer Anzeiger"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1159\/000145564"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.126.6.1225"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.143701"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2008.05.001"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aag0053"},{"key":"e_1_2_7_13_1","volume-title":"The Virtual Human Embryo\u2014The endownment for human development, inc.: Computer Imaging Laboratory","author":"Gasser R.F.","year":"2017"},{"key":"e_1_2_7_14_1","volume-title":"Hamilton, Boyd and Mossman's Human embryology. 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