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In addition, contrary to previous assumptions, studies on awake patients during surgery have demonstrated that the mechanical stimulation of the pia mater and small cerebral vessels can also produce pain. The trigeminovascular system, located at the interface between the nervous and vascular systems, is therefore perfectly positioned to detect sensory inputs and influence blood flow regulation. Despite the fact that it remains only partially understood, the trigeminovascular system is most probably involved in several pathologies, including very frequent ones such as migraine, or other severe conditions, such as subarachnoid haemorrhage. The incomplete knowledge about the exact roles of the trigeminal system in headache, blood flow regulation, blood barrier permeability and trigemino\u2010cardiac reflex warrants for an increased investigation of the anatomy and physiology of the trigeminal system. This translational review aims at presenting comprehensive information about the dural and brain afferents of the trigeminovascular system, in order to improve the understanding of trigeminal cranial sensory perception and to spark a new field of exploration for headache and other brain diseases.<\/jats:p>","DOI":"10.1111\/joa.13413","type":"journal-article","created":{"date-parts":[[2021,2,20]],"date-time":"2021-02-20T22:19:38Z","timestamp":1613859578000},"page":"1-11","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["The trigeminal system: The meningovascular complex\u2014 A review"],"prefix":"10.1111","volume":"239","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3445-7773","authenticated-orcid":false,"given":"Louis\u2010Marie","family":"Terrier","sequence":"first","affiliation":[{"name":"UMR 1253 ibrain Universit\u00e9 de Tours Inserm Tours France"},{"name":"CHRU de Tours Tours France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nouchine","family":"Hadjikhani","sequence":"additional","affiliation":[{"name":"Martinos Center for Biomedical Imaging Harvard Medical School\/MGH\/MIT Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phane","family":"Velut","sequence":"additional","affiliation":[{"name":"UMR 1253 ibrain Universit\u00e9 de Tours Inserm Tours France"},{"name":"CHRU de Tours Tours France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Magnain","sequence":"additional","affiliation":[{"name":"Athinoula A. 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