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The objective of this study was to use a large sample of cadaveric ossicles to create a set of three\u2010dimensional models and study their statistical variance. Thirty\u2010three cadaveric temporal bone samples were scanned using micro\u2010computed tomography (\u03bcCT) and segmented. Statistical shape models (SSMs) were then made for each ossicle to demonstrate the divergence of morphological features. Results revealed that ossicles were most likely to vary in overall size, but that more specific feature variability was found at the manubrium of the malleus, the long process and lenticular process of the incus, and the crura and footplate of the stapes. By analyzing samples as whole ossicular chains, it was revealed that when fixed at the malleus, changes along the chain resulted in a wide variety of final stapes positions. This is the first known study to create high\u2010quality, three\u2010dimensional SSMs of the human ossicles. This information can be used to guide otological surgical training and planning, inform ossicular prosthesis development, and assist with other ossicular studies and applications by improving automated segmentation algorithms. All models have been made publicly available.<\/jats:p>","DOI":"10.1111\/joa.13457","type":"journal-article","created":{"date-parts":[[2021,5,31]],"date-time":"2021-05-31T15:42:29Z","timestamp":1622475749000},"page":"771-781","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Micro\u2010CT of the human ossicular chain: Statistical shape modeling and implications for otologic surgery"],"prefix":"10.1111","volume":"239","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1645-2493","authenticated-orcid":false,"given":"Mandolin L.","family":"Bartling","sequence":"first","affiliation":[{"name":"Schulich School of Medicine and Dentistry Western University London Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyed A.","family":"Rohani","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Western University London Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanif M.","family":"Ladak","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Western University London Canada"},{"name":"Department of Medical Biophysics Western University London Canada"},{"name":"Department of Electrical and Computer Engineering Western University London Canada"},{"name":"National Centre for Audiology Western University London Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumit K.","family":"Agrawal","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Western University London Canada"},{"name":"National Centre for Audiology Western University London Canada"},{"name":"Cochlear Implant Program London Health Sciences Centre London Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,5,31]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"crossref","unstructured":"B\u00f4ne A. 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