{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T23:29:41Z","timestamp":1776900581763,"version":"3.51.2"},"reference-count":43,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,5,24]],"date-time":"2021-05-24T00:00:00Z","timestamp":1621814400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Anatomy"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The perinatal period, sensitive for newborn survival, is also one of the most critical moments in human brain development. Perinatal hypoxia due to reduced blood supply to the brain (ischemia) is one of the main causes of neonatal mortality. Brain damage caused by perinatal hypoxia\u2013ischemia (HI) can lead to neuro\u2010 and psychological disorders. However, its impact seems to be region\u2010dependent, with the hippocampus being one of the most affected areas. Among the neuronal populations of the hippocampus, some interneuron groups \u2013 such as somatostatin\u2010 or neuropeptide Y\u2010expressing neurons \u2013 seem to be particularly vulnerable. The limited information available about the effects of HI in the hippocampus comes mainly from animal models and adult human studies. This article presents an immunohistochemical analysis of somatostatin (SOM) and neuropeptide Y (NPY) expression in the developing human hippocampus after perinatal HI. Two rostrocaudal sections of the body of the hippocampus were analysed, and the number of immunostained cells in the polymorphic layer of the dentate gyrus (DG) and the pyramidal cell layer and <jats:italic>stratum<\/jats:italic> <jats:italic>oriens<\/jats:italic> of the CA3, CA2 and CA1 fields of the hippocampus proper were quantified. The results showed a lower density of both neuropeptides in hypoxic compared to control cases. In the HI group, the number of SOM\u2010immunoreactive cell bodies was statistically significantly lower in the pyramidal cell layer and <jats:italic>stratum<\/jats:italic> <jats:italic>oriens<\/jats:italic> of CA1, while the number of NPY\u2010expressing neurons was statistically lower in the pyramidal cell layer of CA2. Besides, the number of SOM\u2010expressing neurons was significantly higher in the <jats:italic>stratum<\/jats:italic> <jats:italic>oriens<\/jats:italic> of CA1 compared to that in CA2. In sum, we observed a different vulnerability of SOM\u2010 and NPY\u2010containing neurons in the developing human hippocampus following perinatal HI damage. Our results could contribute to a better understanding of the behaviour of these neuronal populations under stressful conditions during the perinatal period.<\/jats:p>","DOI":"10.1111\/joa.13458","type":"journal-article","created":{"date-parts":[[2021,5,24]],"date-time":"2021-05-24T11:54:10Z","timestamp":1621857250000},"page":"856-868","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Neuropeptides in the developing human hippocampus under hypoxic\u2013ischemic conditions"],"prefix":"10.1111","volume":"239","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8240-4348","authenticated-orcid":false,"given":"Joaqu\u00edn","family":"Gonz\u00e1lez Fuentes","sequence":"first","affiliation":[{"name":"Cellular Neuroanatomy and Molecular Chemistry of Central Nervous System School of Pharmacy and School of Medicine University of Castilla\u2010La Mancha (UCLM) Centro Regional de Investigaciones Biom\u00e9dicas Albacete Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo","family":"Insausti Serrano","sequence":"additional","affiliation":[{"name":"Human Neuroanatomy Laboratory School of Medicine UCLM Albacete Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra","family":"Cebada S\u00e1nchez","sequence":"additional","affiliation":[{"name":"School of Nursing UCLM Albacete Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Jos\u00e9","family":"Lagartos Donate","sequence":"additional","affiliation":[{"name":"Department of Clinical Molecular Biology University of Oslo Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eloy","family":"Rivas Infante","sequence":"additional","affiliation":[{"name":"Pathological Anatomy Service Virgen del Roc\u00edo Hospital Seville Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda del Mar","family":"Arroyo Jim\u00e9nez","sequence":"additional","affiliation":[{"name":"Cellular Neuroanatomy and Molecular Chemistry of Central Nervous System School of Pharmacy and School of Medicine University of Castilla\u2010La Mancha (UCLM) Centro Regional de Investigaciones Biom\u00e9dicas Albacete Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6303-1654","authenticated-orcid":false,"given":"Mar\u00eda del Pilar","family":"Marcos Rabal","sequence":"additional","affiliation":[{"name":"Cellular Neuroanatomy and Molecular Chemistry of Central Nervous System School of Pharmacy and School of Medicine University of Castilla\u2010La Mancha (UCLM) Centro Regional de Investigaciones Biom\u00e9dicas Albacete Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,5,24]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.2000.7492"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0167-0115(93)90382-I"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2335"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-014-1929-2"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2014.04.018"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aanat.2015.06.001"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.npep.2008.09.008"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01954858"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1994.tb55790.x"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-03661-3_1"},{"key":"e_1_2_10_12_1","first-page":"1","article-title":"Interneurons in rat hippocampus after cerebral ischemia. 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