{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T23:29:25Z","timestamp":1791502165167,"version":"4.3.4"},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,8,19]],"date-time":"2021-08-19T00:00:00Z","timestamp":1629331200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Anatomy"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Repaired unilateral cleft lip and palate (UCLP) is often accompanied by the deformity and asymmetry of the nasal region. Three\u2010dimensional analysis was performed to investigate the relationship between nasal soft\u2010 and hard\u2010tissue asymmetries, as well as the changes in nasal asymmetry with age, among children with repaired UCLP (age: 6\u201312\u00a0years). Forty\u2010seven patients were included in this study. Their computed tomography records were retrieved for analysis of the 3D asymmetry of 10\u00a0landmarks of the nasal soft and hard tissues. We observed that asymmetry was more severe in nasal hard tissues than in soft tissues, particularly in the sagittal dimension. Compared with patients aged 6\u20139\u00a0years old, patients aged 10 to 12\u00a0years old had significantly increased vertical asymmetry at the base of the alar groove (Gbase, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.027) and the lateral point of the piriform aperture (LPA), (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001). The correlation between the LPA and the alar region was weak to moderate (<jats:italic>r\u00a0<\/jats:italic>=\u00a00.290 to 0.488). In conclusion, we found no evidence of growth and development in nasal hard\u2010tissue asymmetry among 6\u2010 to 12\u2010year\u2010old children with repaired UCLP, except for the vertical dimension. Nasal soft tissue exhibited a more preferable symmetry than hard tissue, and this could be attributed to the compensatory growth of nasal soft tissue, particularly in the vertical and sagittal dimensions. The weak to moderate correlations between nasal soft\u2010tissue asymmetry and hard\u2010tissue asymmetry were observed in the three dimensions. Surgeons should consider these factors when repositioning the nasal alar and controlling the size of the nostrils.<\/jats:p>","DOI":"10.1111\/joa.13538","type":"journal-article","created":{"date-parts":[[2021,8,19]],"date-time":"2021-08-19T19:07:52Z","timestamp":1629400072000},"page":"155-165","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Nasal asymmetry changes during growth and development in 6\u2010 to 12\u2010year\u2010old children with repaired unilateral cleft lip and palate: A 3D computed tomography analysis"],"prefix":"10.1111","volume":"240","author":[{"given":"Le","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Stomatology Shenzhen Luohu Hospital Group Luohu People's Hospital Guangdong P.R. China"},{"name":"Department of Stomatology Shenzhen Second People's Hospital Guangdong P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziling","family":"Wang","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry The University of Hong Kong Hong Kong S.A.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyi","family":"Shan","sequence":"additional","affiliation":[{"name":"Orthodontics Division of Paediatric Dentistry and Orthodontics Faculty of Dentistry The University of Hong Kong Hong Kong S.A.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andy Wai Kan","family":"Yeung","sequence":"additional","affiliation":[{"name":"Applied Oral Sciences &amp; Community Dental Care Faculty of Dentistry The University of Hong Kong Hong Kong S.A.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanqi","family":"Yang","sequence":"additional","affiliation":[{"name":"Orthodontics Division of Paediatric Dentistry and Orthodontics Faculty of Dentistry The University of Hong Kong Hong Kong S.A.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhigang","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Stomatology Shenzhen Second People's Hospital Guangdong P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6447-9573","authenticated-orcid":false,"given":"Min","family":"Gu","sequence":"additional","affiliation":[{"name":"Orthodontics Division of Paediatric Dentistry and Orthodontics Faculty of Dentistry The University of Hong Kong Hong Kong S.A.R. 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