{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T12:41:21Z","timestamp":1769085681252,"version":"3.49.0"},"reference-count":22,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,1,3]],"date-time":"2022-01-03T00:00:00Z","timestamp":1641168000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AR069047"],"award-info":[{"award-number":["AR069047"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Anatomy"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This study aimed to determine the structural features between immature and mature articular cartilage from the humeral and femoral joints of rabbits. Specimens of articular cartilage (n = 6 for immature tissue, n = 6 for mature tissue) that were still attached to the underlying bone from a humerus (shoulder joint) or femur (knee joint) were imaged using microscopic MRI (\u00b5MRI) and polarized light microscopy (PLM). Quantitative \u00b5MRI data with a pixel resolution of 11.7\u201313.2\u00a0\u00b5m revealed a number of differences between the immature and mature cartilage, including total thickness, and T2 and T1\u03c1 relaxation values. Quantitative PLM data with a pixel resolution of 0.25\u20131\u00a0\u00b5m confirmed the \u00b5MRI results and revealed additional differences in cellular features between the tissues. The mature cartilage had a clearly defined tidemark, which was absent in the immature tissue. The ability to differentiate specific maturation\u2010related cartilage characteristics could be beneficial to translational studies of degenerative diseases such as osteoarthritis.<\/jats:p>","DOI":"10.1111\/joa.13620","type":"journal-article","created":{"date-parts":[[2022,1,4]],"date-time":"2022-01-04T03:39:06Z","timestamp":1641267546000},"page":"1141-1151","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Structural differences between immature and mature articular cartilage of rabbits by microscopic MRI and polarized light microscopy"],"prefix":"10.1111","volume":"240","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3962-4761","authenticated-orcid":false,"given":"Hannah","family":"Mantebea","sequence":"first","affiliation":[{"name":"Department of Physics and Center for Biomedical Research Oakland University  Rochester MI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Syeda","family":"Batool","sequence":"additional","affiliation":[{"name":"Department of Physics and Center for Biomedical Research Oakland University  Rochester MI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amanveer","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Physics and Center for Biomedical Research Oakland University  Rochester MI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammed","family":"Hammami","sequence":"additional","affiliation":[{"name":"Department of Physics and Center for Biomedical Research Oakland University  Rochester MI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Farid","family":"Badar","sequence":"additional","affiliation":[{"name":"Department of Physics and Center for Biomedical Research Oakland University  Rochester MI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4653-1862","authenticated-orcid":false,"given":"Yang","family":"Xia","sequence":"additional","affiliation":[{"name":"Department of Physics and Center for Biomedical Research Oakland University  Rochester MI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,1,3]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/03008200601130950"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.csm.2017.02.001"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mad.2013.11.005"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/JSA.0b013e318210c0aa"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/1941738109350438"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1369\/jhc.4A6511.2005"},{"key":"e_1_2_9_8_1","unstructured":"Kingfisher (Volume 1; No. 2) Kingfisher Biotech Circular Subject: Rabbit as an Animal Model. Available from:https:\/\/www.Kingfisherbiotech.com\/newsletter\/Rabbit_Animal_Model_Newsletter.pdf(Accessed 15th February 2021)."},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/jemt.22209"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2005.01.006"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmr.2018.10.008"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2818.1995.tb03669.x"},{"issue":"1","key":"e_1_2_9_13_1","first-page":"51","article-title":"Articular cartilage restoration of the knee","volume":"65","author":"Shah M.R.","year":"2007","journal-title":"Bulletin of the NYU Hospital for Joint Diseases"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1088\/0031-9155\/60\/22\/8709"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmr.2011.06.031"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10334-011-0288-1"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1203\/PDR.0b013e31816b4fe5"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0736-0266(01)00052-3"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910390612"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004424-200010000-00007"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1039\/9781782623663-00001"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsb.2008.06.009"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1053\/joca.2000.0405"}],"container-title":["Journal of Anatomy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/joa.13620","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/joa.13620","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/joa.13620","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T16:52:23Z","timestamp":1692982343000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/joa.13620"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,3]]},"references-count":22,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022,6]]}},"alternative-id":["10.1111\/joa.13620"],"URL":"https:\/\/doi.org\/10.1111\/joa.13620","archive":["Portico"],"relation":{},"ISSN":["0021-8782","1469-7580"],"issn-type":[{"value":"0021-8782","type":"print"},{"value":"1469-7580","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1,3]]},"assertion":[{"value":"2021-06-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-12-20","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-01-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}