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Considering that particular research interest is lacking, we aimed to assess alcoholic liver cirrhosis (ALC)\u2013induced changes in osteocyte lacunar network and bone marrow adiposity. Immunohistochemistry was conducted to assess changes in the micro\u2010morphology of osteocyte lacunar network and bone marrow adiposity, and expression of connexin 43 and sclerostin in vertebral and femoral samples collected from 40 cadaveric men (age range between 44 and 70\u00a0years) divided into ALC group (<jats:italic>n<\/jats:italic>\u00a0=\u00a020) and control group (<jats:italic>n<\/jats:italic>\u00a0=\u00a020). Furthermore, the assessment of the potential association between bone changes and the severity of the hepatic disorder (given by Knodell's pathohistologic scoring) was conducted. Our data revealed fewer connexin 43\u2010positive osteocytes per vertebral and femoral bone area (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.01), suggesting defective signal transduction among osteocytes in ALC individuals. Moreover, we found an ALC\u2010induced increase in the number of adipocytes in the vertebral bone marrow (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.038). Considering significant associations between the severity of liver tissue disturbances and impaired functionality of osteocyte lacunar network (Pearson's correlation analyses, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05), we may assume that timely treatment of the liver disease may delay bone impairment. ALC induced an increase in osteocytic sclerostin expression (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001), suggesting its role in mediating low bone formation among ALC individuals. Hence, medicaments targeting low bone formation may be beneficial to attenuate the bone changes among ALC patients. However, future clinical studies are required to verify the therapeutic utility of these findings.<\/jats:p>","DOI":"10.1111\/joa.13621","type":"journal-article","created":{"date-parts":[[2022,1,3]],"date-time":"2022-01-03T10:45:05Z","timestamp":1641206705000},"page":"1162-1173","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["The altered osteocytic expression of connexin 43 and sclerostin in human cadaveric donors with alcoholic liver cirrhosis: Potential treatment targets"],"prefix":"10.1111","volume":"240","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3124-1400","authenticated-orcid":false,"given":"Jelena","family":"Jadzic","sequence":"first","affiliation":[{"name":"Laboratory of Bone Biology and Bioanthropology Faculty of Medicine Institute of Anatomy University of Belgrade  Belgrade 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Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5501-423X","authenticated-orcid":false,"given":"Slobodan","family":"Nikolic","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Institute of Forensic Medicine University of Belgrade  Belgrade Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2396-3868","authenticated-orcid":false,"given":"Nada","family":"Tomanovic","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Institute of Pathology University of Belgrade  Belgrade Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6267-827X","authenticated-orcid":false,"given":"Marija P.","family":"Djuric","sequence":"additional","affiliation":[{"name":"Laboratory of Bone Biology and Bioanthropology Faculty of Medicine Institute of Anatomy University of Belgrade  Belgrade Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1043-1077","authenticated-orcid":false,"given":"Danijela","family":"Djonic","sequence":"additional","affiliation":[{"name":"Laboratory of Bone Biology and Bioanthropology Faculty of Medicine Institute of Anatomy University of Belgrade  Belgrade 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