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To date, VENs have been found in limbic sectors of the frontal, temporal and insular lobes. In humans, their density seems to decrease in the caudo\u2010rostral and ventro\u2010dorsal direction; that is, from the anterior regions of the cingulate and insular cortices towards the frontal pole and the superior frontal gyrus. Several studies have provided similar descriptions of the shape of the VEN soma, but the size of the soma varies from one cortical region to another. There is consensus among different authors about the selective vulnerability of VENs in certain pathologies, in which a deterioration of the capacities involved in social behaviour is observed. In this review, we propose that the restriction of VENs towards the sectors linked to limbic information processing in <jats:italic>Homo sapiens<\/jats:italic> gives them a possible functional role in relation to the structures in which they are located. However, given the divergence in characteristics such as location, density, size and biochemical profile among VENs of different cortical sectors, the activities in which they participate could allow them to partake in a wide spectrum of neurological functions, including autonomic responses and executive functions.<\/jats:p>","DOI":"10.1111\/joa.13642","type":"journal-article","created":{"date-parts":[[2022,2,18]],"date-time":"2022-02-18T04:33:53Z","timestamp":1645158833000},"page":"20-32","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Von Economo neurons: Cellular specialization of human limbic cortices?"],"prefix":"10.1111","volume":"241","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2346-8362","authenticated-orcid":false,"given":"Carlos A.","family":"Gonz\u00e1lez\u2010Acosta","sequence":"first","affiliation":[{"name":"Centro de Estudios Cerebrales, Facultad de Salud Universidad del Valle  Cali Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0224-3941","authenticated-orcid":false,"given":"Daniela","family":"Ortiz\u2010Mu\u00f1oz","sequence":"additional","affiliation":[{"name":"Centro de Estudios Cerebrales, Facultad de Salud Universidad del Valle  Cali Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4468-6716","authenticated-orcid":false,"given":"Lina V.","family":"Becerra\u2010Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Centro de Estudios Cerebrales, Facultad de Salud Universidad del Valle  Cali Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel F.","family":"Casanova","sequence":"additional","affiliation":[{"name":"Center for Childhood Neurotherapeutics University of South Carolina School of Medicine Greenville  Greenville South Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6747-9587","authenticated-orcid":false,"given":"Efra\u00edn","family":"Buritic\u00e1","sequence":"additional","affiliation":[{"name":"Centro de Estudios Cerebrales, Facultad de Salud Universidad del Valle  Cali Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,2,17]]},"reference":[{"key":"e_1_2_15_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/107385840200800409"},{"key":"e_1_2_15_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2005.06.008"},{"key":"e_1_2_15_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00429\u2010010\u20100254\u20100"},{"key":"e_1_2_15_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749\u20106632.2011.06011.x"},{"key":"e_1_2_15_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/joa.13068"},{"key":"e_1_2_15_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/7.7.635"},{"key":"e_1_2_15_8_1","first-page":"231","article-title":"Ueber die feiner Structur der Gehirnrinde des Menschen","volume":"19","author":"Betz W.","year":"1881","journal-title":"Zentralbl Med Wiss"},{"key":"e_1_2_15_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnen\/nlx104"},{"key":"e_1_2_15_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401\u2010010\u20100673\u20102"},{"key":"e_1_2_15_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0020936"},{"key":"e_1_2_15_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.22055"},{"key":"e_1_2_15_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cortex.2011.10.004"},{"key":"e_1_2_15_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.22875"},{"key":"e_1_2_15_15_1","doi-asserted-by":"crossref","unstructured":"Butti C.andHof P. 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