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The effects of AIS on the alignment of the cervical spine, including the effects of surgery, has been less well studied. The objective of this study was to identify, using regression analysis, the significant relationships between the alignment of the thoracolumbar spine, in both the coronal and sagittal planes, and the sagittal alignment of the cervical spine in AIS. This study used coronal and sagittal radiographic measures from a group with AIS, both pre and post\u2010operatively, which were analysed using multiple linear regression methods to identify significant parameters that explain the sagittal shape of the cervical spine. There were 51 pairs of pre and post\u2010operative radiographs analysed, 40 of which were Lenke 1 curves and 11 Lenke 3 curves. Posterior spinal fusion was performed for all. The significant parameters pre\u2010operatively were T1 slope, thoracic kyphosis, lumbar lordosis and SVA with an R<jats:sup>2<\/jats:sup> value of 78%. Post\u2010operatively, the significant parameters were T1 slope, thoracic kyphosis, lumbar lordosis and thoracolumbar scoliosis with an R<jats:sup>2<\/jats:sup> of 63%. The sagittal alignment of the cervical spine in AIS is related to the shape of key parameters in the rest of the spine. Changes in the cervical sagittal shape occur to compensate for changes in shape to the rest of the spine that occur as a consequence of surgery. This has implications for the understanding of how the compensatory mechanisms of the spine are used to maintain a horizontal gaze, along with prediction of the effects of surgery on the shape of the spine.<\/jats:p>","DOI":"10.1111\/joa.13662","type":"journal-article","created":{"date-parts":[[2022,4,4]],"date-time":"2022-04-04T08:59:22Z","timestamp":1649062762000},"page":"437-446","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Statistical modelling of how the sagittal alignment of the cervical spine is affected by adolescent idiopathic scoliosis and how scoliosis surgery changes that"],"prefix":"10.1111","volume":"241","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6532-7950","authenticated-orcid":false,"given":"Adrian","family":"Gardner","sequence":"first","affiliation":[{"name":"Aston University The Royal Orthopaedic Hospital NHS Foundation Trust  Birmingham UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fiona","family":"Berryman","sequence":"additional","affiliation":[{"name":"The Royal Orthopaedic Hospital NHS Foundation Trust  Birmingham UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Pynsent","sequence":"additional","affiliation":[{"name":"The University of Birmingham  Birmingham UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,4,4]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1109\/TAC.1974.1100705"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/BRS.0b013e3182a7f449"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.21037\/jss.2018.05.17"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.2174\/1874325001610010143"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00586-021-06904-2"},{"key":"e_1_2_12_7_1","first-page":"261","article-title":"Outline for the study of scoliosis","volume":"5","author":"Cobb J.","year":"1948","journal-title":"AAOS Instructional Course Lectures"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/BRS.0000000000001698"},{"key":"e_1_2_12_9_1","volume-title":"The pediatric spine: Principles and practice","author":"Dubousset J.","year":"1994"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/BPO.0b013e31824b285f"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2019.10.064"},{"key":"e_1_2_12_12_1","volume-title":"An R companion to applied regression","author":"Fox J.","year":"2011"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-81818-z"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/joa.13454"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s43390-021-00366-8"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00586-017-5321-2"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nec.2013.01.001"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.3171\/2016.9.PEDS16298"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00586-018-5753-3"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.spinee.2017.09.008"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00247-006-0191-5"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/BSD.0b013e318261f346"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-200108000-00006"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12891-021-04884-4"},{"key":"e_1_2_12_25_1","unstructured":"L\u00fcdecke D.(2021). sjPlot: Data visualisation for statistics in social science. 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