{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T09:37:39Z","timestamp":1769506659072,"version":"3.49.0"},"reference-count":19,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,8,24]],"date-time":"2022-08-24T00:00:00Z","timestamp":1661299200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Anatomy"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Branch retinal vein occlusion (BRVO) is a frequent retinal vascular disease that may cause extensive microvascular remodeling leading to severe visual impairment. Little is known regarding the histology of non\u2010neovascular microvascular remodeling. Here, we examined by confocal microscopy the structure of retinal microvessels of a donor eye with longstanding BRVO. The post\u2010mortem retina of a 91\u2010year\u2010old woman that had superotemporal BRVO for 2\u2009years was examined by confocal microscopy after anti\u2010collagen IV (collIV), alpha\u2010smooth muscle cell (\u03b1SMA), and anti\u2010von Willebrand factor (vWf) immunolabeling. In the retinal quadrant affected by BRVO, extensive vascular remodeling affected all vessels, from arterioles to venules, including the foveal avascular zone. Most affected vessels were either irregularly dilated or, on the opposite, reduced to micrometric\u2010size CollIV positive, vWf negative, nuclear\u2010staining negative strings. Telangiectatic capillaries of various sizes and shapes were seen, the largest one (233\u2009\u03bcm) being located in the parafoveal area. Some telangiectatic capillaries had a thick, multilayered vWf\u2010 and CollIV\u2010positive wall, that often occluded the lumen. Other features included double\u2010channeled arterioles. The majority of microvascular abnormalities were devoid of nuclear staining, suggesting extensive loss of endothelial cells. We describe the spectrum of microvascular abnormalities upstream of a longstanding BRVO. This spectrum comprises a large parafoveal telangiectatic capillary corresponding to what has been previously clinically defined as TelCap. The absence of intraluminal nuclear staining in the majority of abnormal vessels raises the hypothesis that the loss of endothelial cells plays a crucial role in the development of the different manifestations of capillary remodeling. The presence of vWF in de\u2010endothelialized vessels suggests deposition of plasma, hence that they may remain perfused. Our work may help to understand the clinical imaging features of TelCaps.<\/jats:p>","DOI":"10.1111\/joa.13743","type":"journal-article","created":{"date-parts":[[2022,8,24]],"date-time":"2022-08-24T16:53:04Z","timestamp":1661359984000},"page":"235-244","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Confocal microscopy of telangiectatic capillaries (<scp>TelCaps<\/scp>) and other features of microvascular remodeling following branch retinal vein occlusion"],"prefix":"10.1111","volume":"243","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9065-2528","authenticated-orcid":false,"given":"Marie","family":"Darche","sequence":"first","affiliation":[{"name":"Quinze\u2010Vingts Hospital, Institut National de la Recherche M\u00e9dicale, Direction g\u00e9n\u00e9rale de l'offre de soins, centre d'investigation clinique 1423  Paris France"},{"name":"Institut de la Vision, INSERM, UMR968  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Verschueren","sequence":"additional","affiliation":[{"name":"Quinze\u2010Vingts Hospital, Institut National de la Recherche M\u00e9dicale, Direction g\u00e9n\u00e9rale de l'offre de soins, centre d'investigation clinique 1423  Paris France"},{"name":"Institut de la Vision, INSERM, UMR968  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela","family":"Castro Farias","sequence":"additional","affiliation":[{"name":"Quinze\u2010Vingts Hospital, Institut National de la Recherche M\u00e9dicale, Direction g\u00e9n\u00e9rale de l'offre de soins, centre d'investigation clinique 1423  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ys\u00e9","family":"Borella","sequence":"additional","affiliation":[{"name":"Quinze\u2010Vingts Hospital, Institut National de la Recherche M\u00e9dicale, Direction g\u00e9n\u00e9rale de l'offre de soins, centre d'investigation clinique 1423  Paris France"},{"name":"Institut de la Vision, INSERM, UMR968  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michel","family":"Paques","sequence":"additional","affiliation":[{"name":"Quinze\u2010Vingts Hospital, Institut National de la Recherche M\u00e9dicale, Direction g\u00e9n\u00e9rale de l'offre de soins, centre d'investigation clinique 1423  Paris France"},{"name":"Institut de la Vision, INSERM, UMR968  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,8,24]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.47.9.521"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600\u20100420.1998.760601.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-009-1175-6"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006982\u2010198707040\u201000011"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2019-314355"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0002\u20109394(14)70687\u20107"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.13-13122"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1039\/c3ib20259c"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1982.01030040110020"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10384-018-0570-0"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V88.10.3862.bloodjournal88103862"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10030405"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1385\/ao:38:1:73"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469\u20107580.1999.19410089.x"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1159\/000437360"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-01183-9"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V83.5.1244.1244"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.7189\/jogh.09.010427"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.79.4.362"}],"container-title":["Journal of Anatomy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/joa.13743","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/joa.13743","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/joa.13743","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,16]],"date-time":"2023-08-16T20:20:47Z","timestamp":1692217247000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/joa.13743"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,24]]},"references-count":19,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,8]]}},"alternative-id":["10.1111\/joa.13743"],"URL":"https:\/\/doi.org\/10.1111\/joa.13743","archive":["Portico"],"relation":{},"ISSN":["0021-8782","1469-7580"],"issn-type":[{"value":"0021-8782","type":"print"},{"value":"1469-7580","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,24]]},"assertion":[{"value":"2022-01-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-07-20","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-08-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}