{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T00:42:51Z","timestamp":1768696971325,"version":"3.49.0"},"reference-count":42,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,4,11]],"date-time":"2023-04-11T00:00:00Z","timestamp":1681171200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Anatomy"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Our understanding of the initiation and cellular mechanisms underlying endochondral resorption of Meckel's cartilage (MC) remains limited. Several studies have shown that the resorption site of MC and the mandibular incisor tooth germ are located close to each other. However, whether incisor tooth germ development is involved in MC resorption remains unclear. In this study, we aimed to elucidate the spatio\u2010temporal interaction between the initiation site of MC resorption and the development of incisor tooth germs in an embryonic mouse model. To this effect, we developed a histology\u2010based three\u2010dimensional (3D) reconstruction technique using paraffin\u2010embedded serial sections of various tissues in the jaw. The serial sections were cut in the frontal section and the tissue constituents (e.g., MC, incisor, and mineralized mandible) were studied using conventional and enzyme\u2010based histochemistry. The outline of each component was marked on the frontal sectional images and 3D structures were constructed. To assess the vascular architecture at the site of MC resorption, immunohistochemical staining using anti\u2010laminin, anti\u2010factor VIII, and anti\u2010VEGF antibodies was performed. MC resorption was first observed on the lateral incisor\u2010facing side of the cartilage rods at sites anterior to the mental foramen on E16.0. The 3D analysis suggested that: (a) the posterior region of the clastic cartilage resorption corresponds to the cervical loop of the incisor; (b) the cervical portion of the tooth germ inflates probably due to temporal cellular congestion prior to differentiation into matrix\u2010producing cells; (c) the incisor tooth germ tissue is present in close proximity to MC even in mouse with continuously growing tooth and determines the disappearance of MC as the tooth development.<\/jats:p>","DOI":"10.1111\/joa.13875","type":"journal-article","created":{"date-parts":[[2023,4,11]],"date-time":"2023-04-11T08:16:10Z","timestamp":1681200970000},"page":"534-544","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The relationship between Meckel's cartilage resorption and incisor tooth germ in mice"],"prefix":"10.1111","volume":"243","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5818-4055","authenticated-orcid":false,"given":"Yoshihito","family":"Shimazu","sequence":"first","affiliation":[{"name":"Department of Food and Life Science, School of Life and Environmental Science Azabu University  Sagamihara Kanagawa Japan"},{"name":"Department of Pathology The Nippon Dental University School of Life Dentistry at Tokyo  Chiyoda\u2010ku Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuji","family":"Taya","sequence":"additional","affiliation":[{"name":"Department of Pathology The Nippon Dental University School of Life Dentistry at Tokyo  Chiyoda\u2010ku Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuuichi","family":"Soeno","sequence":"additional","affiliation":[{"name":"Department of Pathology The Nippon Dental University School of Life Dentistry at Tokyo  Chiyoda\u2010ku Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoo","family":"Kudo","sequence":"additional","affiliation":[{"name":"Department of Pathology The Nippon Dental University School of Life Dentistry at Tokyo  Chiyoda\u2010ku Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaori","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Pathology The Nippon Dental University School of Life Dentistry at Tokyo  Chiyoda\u2010ku Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mamoru","family":"Takeda","sequence":"additional","affiliation":[{"name":"Department of Food and Life Science, School of Life and Environmental Science Azabu University  Sagamihara Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,4,11]]},"reference":[{"key":"e_1_2_10_2_1","first-page":"125","article-title":"Meckel's cartilage: discovery, 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