{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:33:53Z","timestamp":1747186433934,"version":"3.40.5"},"reference-count":57,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,11,27]],"date-time":"2023-11-27T00:00:00Z","timestamp":1701043200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32171137"],"award-info":[{"award-number":["32171137"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Anatomy"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Corticotropin\u2010releasing hormone (CRH) neurons are densely distributed in the medial prefrontal cortex (mPFC), which plays a crucial role in integrating and processing emotional and cognitive inputs from other brain regions. Therefore, it is important to know the neural afferent patterns of mPFC<jats:sup>CRH<\/jats:sup> neurons, which are still unclear. Here, we utilized a rabies virus\u2010based monosynaptic retrograde tracing system to map the presynaptic afferents of the mPFC<jats:sup>CRH<\/jats:sup> neurons throughout the entire brain. The results show that the mPFC<jats:sup>CRH<\/jats:sup> neurons receive inputs from three main groups of brain regions: (1) the cortex, primarily the orbital cortex, somatomotor areas, and anterior cingulate cortex; (2) the thalamus, primarily the anteromedial nucleus, mediodorsal thalamic nucleus, and central medial thalamic nucleus; and (3) other brain regions, primarily the basolateral amygdala, hippocampus, and dorsal raphe nucleus. Taken together, our results are valuable for further investigations into the roles of the mPFC<jats:sup>CRH<\/jats:sup> neurons in normal and neurological disease states. These investigations can shed light on various aspects such as cognitive processing, emotional modulation, motivation, sociability, and pain.<\/jats:p>","DOI":"10.1111\/joa.13981","type":"journal-article","created":{"date-parts":[[2023,11,27]],"date-time":"2023-11-27T22:42:47Z","timestamp":1701124967000},"page":"527-536","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Whole\u2010brain mapping of monosynaptic afferent inputs to the <scp>CRH<\/scp> neurons in the medial prefrontal cortex of mice"],"prefix":"10.1111","volume":"244","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-9602-6666","authenticated-orcid":false,"given":"Xiao\u2010Lan","family":"Li","sequence":"first","affiliation":[{"name":"Institute of Basic Medicine and Forensic Medicine North Sichuan Medical College  Nanchong China"},{"name":"Department of Human Anatomy, Histology and Embryology and K.K. Leung Brain Research Centre Air Force Military Medical University  Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fei","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Human Anatomy, Histology and Embryology and K.K. Leung Brain Research Centre Air Force Military Medical University  Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin\u2010Yi","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Human Anatomy, Histology and Embryology and K.K. Leung Brain Research Centre Air Force Military Medical University  Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao\u2010Dong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine Inner Mongolia Armed Police Corps Hospital  Hohhot China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhen\u2010Zhen","family":"Kou","sequence":"additional","affiliation":[{"name":"Department of Human Anatomy, Histology and Embryology and K.K. 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