{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T11:22:44Z","timestamp":1770549764989,"version":"3.49.0"},"reference-count":83,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,4,6]],"date-time":"2024-04-06T00:00:00Z","timestamp":1712361600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004281","name":"Narodowe Centrum Nauki","doi-asserted-by":"publisher","award":["2019\/35\/B\/NZ4\/00905"],"award-info":[{"award-number":["2019\/35\/B\/NZ4\/00905"]}],"id":[{"id":"10.13039\/501100004281","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Anatomy"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This study investigated the pancreas differentiation of two species of gekkotan families\u2014the mourning gecko <jats:italic>Lepidodactylus lugubris<\/jats:italic> (Gekkonidae) and the leopard gecko <jats:italic>Eublepharis macularius<\/jats:italic> (Eublepharidae)\u2014based on two\u2010dimensional (2D) histological samples and three\u2010dimensional (3D) reconstructions of the position of the pancreatic buds and the surrounding organs. The results showed that at the moment of egg laying, the pancreas of <jats:italic>L. lugubris<\/jats:italic> is composed of three distinct primordia: one dorsal and two ventral. The dorsal primordium differentiates earlier than either ventral primordium. The right ventral primordium is more prominent and distinctive, starting to form earlier than the left one. Moreover, at this time, the pancreas of the leopard gecko is composed of the dorsal and right ventral primordium and the duct of the left ventral primordium. It means that the leopard gecko's left primordium is a transitional structure. These results indicate that the early development of the gekkotan pancreas is species specific. The pancreatic buds of the leopard and mourning gecko initially enter the duodenum by separate outlets, similar to the pancreas of other vertebrates. The pancreatic buds (3 of the mourning gecko and 2 of the leopard gecko) fuse quickly and form an embryonic pancreas. After that, the structure of this organ changes. After fusion, the pancreas of both gekkotans comprises four parts: the head of the pancreas (central region) and three lobes: upper, splenic, and lower. This organ develops gradually and is very well distinguished at hatching time. In both gekkotan species, cystic, hepatic, and pancreatic ducts enter the duodenum within the papilla. During gekkotan pancreas differentiation, the connection between the common bile duct and the dorsal pancreatic duct is associated with intestinal rotation, similar to other vertebrates.<\/jats:p>","DOI":"10.1111\/joa.14038","type":"journal-article","created":{"date-parts":[[2024,4,6]],"date-time":"2024-04-06T03:11:15Z","timestamp":1712373075000},"page":"303-323","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Does the pancreas of gekkotans differentiate similarly? Developmental structural and <scp>3D<\/scp> studies of the mourning gecko (<i>Lepidodactylus lugubris<\/i>) and the leopard gecko (<i>Eublepharis macularius<\/i>)"],"prefix":"10.1111","volume":"245","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3826-9502","authenticated-orcid":false,"given":"Magdalena","family":"Kowalska","sequence":"first","affiliation":[{"name":"Institute of Biology, Biotechnology and Environmental Protection, Faculty of Natural Sciences University of Silesia in Katowice  Katowice Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0419-6330","authenticated-orcid":false,"given":"Pawe\u0142","family":"Kaczmarek","sequence":"additional","affiliation":[{"name":"Institute of Biology, Biotechnology and Environmental Protection, Faculty of Natural Sciences University of Silesia in Katowice  Katowice Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9496-7524","authenticated-orcid":false,"given":"Weronika","family":"Rupik","sequence":"additional","affiliation":[{"name":"Institute of Biology, Biotechnology and Environmental Protection, Faculty of Natural Sciences University of Silesia in Katowice  Katowice Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,4,6]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01798752"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ympev.2022.107414"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/ede.12042"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0925-4773(02)00190-9"},{"key":"e_1_2_10_6_1","first-page":"1","volume-title":"Technika mikroskopowa. Praktyczny poradnik mikroskopowy (Microscopic technique. Practical guide)","author":"Bagi\u0144ski S.","year":"1969"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-90941-2_4"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1000960105"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-6480(79)90084-4"},{"key":"e_1_2_10_10_1","first-page":"620","article-title":"Recherches sur le d\u00e9veloppement du pancr\u00e9as et du foie (S\u00e9laciens, Reptiles, Mammif\u00e9res)","volume":"32","author":"Brachet A.","year":"1896","journal-title":"Journal of Anatomy and Physiology"},{"key":"e_1_2_10_11_1","first-page":"786","volume-title":"Handbuch der vergleichenden Anatomie der Wirbeltiere","author":"Broman I.","year":"1937"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00429-006-0090-4"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/01478885.2020.1775013"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/jemt.20531"},{"key":"e_1_2_10_15_1","unstructured":"Dum\u00e9ril A.M.C.&Bibron G.(1836)The reptile database. Available from:https:\/\/reptile\u2010database.reptarium.cz\/species?genus=Lepidodactylus&species=lugubris"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg841"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00496625"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00517137"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-6480(75)90201-4"},{"key":"e_1_2_10_20_1","first-page":"9","volume-title":"Zoophysiology","author":"Epple A.","year":"1987"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02118892"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1001020106"},{"key":"e_1_2_10_23_1","first-page":"681","volume-title":"Comparative endocrinology","author":"Frye B.E.","year":"1959"},{"key":"e_1_2_10_24_1","first-page":"1","article-title":"Donnees histologiques sur le pancreas endocrine des lepidosauriens (Reptiles)","volume":"42","author":"Gabe M.","year":"1970","journal-title":"Ergebnisse der Anatomie und Entwicklungsgeschichte"},{"key":"e_1_2_10_25_1","first-page":"3","article-title":"Ricerche istologiche sul tubo digerente dei Rettili. 3 a Nota. Processi verbali delle adunanze della R","volume":"1","author":"Giannelli L.","year":"1896","journal-title":"Accademia dei Fisiocritici in Siena"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2008.10.024"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.72"},{"key":"e_1_2_10_28_1","first-page":"520","volume-title":"Trait\u00e9 de Zoologie: Anatomie, Syst\u00e9matique, Biologie","author":"Guib\u00e9 J.","year":"1970"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.21157\/j.ked.hewan.v10i2.5047"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcz.2016.11.001"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmor.21249"},{"key":"e_1_2_10_32_1","first-page":"581","article-title":"A comparative study of the pancreas","volume":"1926","author":"Hill W.C.O.","year":"1926","journal-title":"Proceedings of the Zoological Society"},{"key":"e_1_2_10_33_1","first-page":"443","volume-title":"Klassen und Ordnungen des Thier\u2010Reichs","author":"Hoffmann C.K.","year":"1890"},{"key":"e_1_2_10_34_1","first-page":"330","article-title":"Defekt\u2010 und Transplantationsversuche an der Anlage von Leber und Pancreas j\u00fcngster Amphibienkeime","volume":"105","author":"Holtfreter J.","year":"1925","journal-title":"Development Genes and Evolution"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1006\/gcen.1994.1081"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.032235"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12983-017-0188-y"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmor.21311"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1159\/000286906"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0177(2000)9999:9999<::AID-DVDY1027>3.0.CO;2-8"},{"key":"e_1_2_10_41_1","first-page":"1","volume-title":"Histological and histochemical methods, theory and practice","author":"Kiernan J.A.","year":"2008"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1101\/SQB.1997.062.01.045"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.zool.2016.11.001"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmor.20806"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmor.20921"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22147601"},{"key":"e_1_2_10_47_1","first-page":"819","article-title":"Sur la formation des ilots de Langerhans dans le pancreas","volume":"5","author":"Laguesse E.","year":"1893","journal-title":"Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales"},{"key":"e_1_2_10_48_1","first-page":"157","article-title":"Sur la structure du pancr\u00e9as chez les ophidiens et particuli\u00e8rement sur les \u00eelots endocrines","volume":"4","author":"Laguesse E.","year":"1901","journal-title":"Archives d'Anatomie Microscopique et de Morphologie Exp\u00e9rimentale"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0925-4773(02)00332-5"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-6480(62)90057-6"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-6480(63)90092-3"},{"key":"e_1_2_10_52_1","first-page":"319","volume-title":"The biology of the Reptilia","author":"Miller M.R.","year":"1970"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.21608\/svu.2021.96063.1149"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1092270212"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.21828"},{"key":"e_1_2_10_56_1","first-page":"1","article-title":"Some observations on the development of the ventral pancreas in man","volume":"65","author":"Odgers P.N.B.","year":"1930","journal-title":"Journal of Anatomy"},{"key":"e_1_2_10_57_1","first-page":"3","article-title":"Sullo sviluppo del pancreas e del fegato nel Gongylus ocellatus","volume":"25","author":"Orr\u00f9 E.","year":"1899","journal-title":"Bullettino e Atti Della Reale Accademia Medica di Roma"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1093\/icb\/13.3.667"},{"key":"e_1_2_10_59_1","first-page":"25","volume-title":"Handbook of physiology","author":"Pictet R.","year":"1972"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(72)90083-8"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-6480(92)90029-J"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1001780202"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1001630207"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1002\/ece3.5164"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.zool.2011.05.002"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.zool.2012.07.001"},{"key":"e_1_2_10_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micron.2012.06.013"},{"key":"e_1_2_10_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.zool.2015.12.005"},{"key":"e_1_2_10_69_1","first-page":"730","article-title":"Recherches sur le Developpement du Pancreas chez les Reptiles","volume":"29","author":"Saint\u2010Remy G.","year":"1893","journal-title":"Journal of Anatomy and Physiology"},{"key":"e_1_2_10_70_1","doi-asserted-by":"publisher","DOI":"10.1242\/bio.012179"},{"key":"e_1_2_10_71_1","first-page":"84","article-title":"Pankreasstudien","volume":"57","author":"Siwe S.A.","year":"1926","journal-title":"Gegenbaurs Morphologisches Jahrbuch"},{"key":"e_1_2_10_72_1","doi-asserted-by":"publisher","DOI":"10.1111\/joa.13871"},{"key":"e_1_2_10_73_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.121.6.1569"},{"key":"e_1_2_10_74_1","doi-asserted-by":"publisher","DOI":"10.1053\/saep.2003.00019-7"},{"key":"e_1_2_10_75_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-6395.2008.00329.x"},{"key":"e_1_2_10_76_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00709-010-0259-9"},{"key":"e_1_2_10_77_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006676-200307000-00007"},{"key":"e_1_2_10_78_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1090820307"},{"key":"e_1_2_10_79_1","first-page":"307","article-title":"The development of the pancreas, the pancreatic and hepatic ducts in Trichosurus vulpecula","volume":"208","author":"Tribe M.","year":"1918","journal-title":"Philosophical Transactions of the Royal Society B"},{"key":"e_1_2_10_80_1","volume-title":"A Contribution to the Classification of Snakes","author":"Underwood G.","year":"1967"},{"key":"e_1_2_10_81_1","first-page":"347","article-title":"Ausf\u00fchrgange der Leber und des Pankreas bei Varanus komodoensis und einigen anderen Reptilien","volume":"80","author":"Van Dijk A.W.","year":"1935","journal-title":"Anatomischer Anzeiger"},{"key":"e_1_2_10_82_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-9009-2_13"},{"key":"e_1_2_10_83_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02884993"},{"key":"e_1_2_10_84_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.20945"}],"container-title":["Journal of Anatomy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/joa.14038","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T14:38:03Z","timestamp":1758724683000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/joa.14038"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,6]]},"references-count":83,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,8]]}},"alternative-id":["10.1111\/joa.14038"],"URL":"https:\/\/doi.org\/10.1111\/joa.14038","archive":["Portico"],"relation":{},"ISSN":["0021-8782","1469-7580"],"issn-type":[{"value":"0021-8782","type":"print"},{"value":"1469-7580","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,6]]},"assertion":[{"value":"2023-11-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-03-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}